Sentences with phrase «vaccine candidates with»

The HVTN's mission is to fully characterize the safety, immunogenicity, and efficacy of HIV vaccine candidates with the goal of developing a safe, effective vaccine as rapidly as possible for prevention of HIV infections globally.

This service will allow users to improve the compatibility and stability of their vaccine antigen with different mucosal adjuvants (from the HZI portfolio) and to define the optimal production methods to generate immunogenic vaccine candidates with optimised physicochemical stability (in vitro studies).

«It's a novel strategy, and it works beautifully,» said senior investigator Harvey M. Friedman, MD, a professor of Infectious Diseases at Penn. «I know of no other HSV2 vaccine candidate with published results that are as promising as this study.»

The Walter Reed Army Institute of Research (WRAIR) announces a Cooperative Research and Development Agreement for the development of a Zika vaccine candidate with Sanofi Pasteur, the vaccines division of Sanofi.

Not exact matches

The shortage also has become an issue on the campaign trail, with Democratic candidate Sen. John Kerry blaming the Bush administration for not paying attention to warning signs about possible shortages and the Bush campaign inferring that vaccine manufacturers are hindered by fears of lawsuits, something the campaign said Kerry would not move to fix.

To address any possible safety concerns associated with this vaccine, the team developed two next generation candidate vaccines that contain further weakened forms of the vaccine.

An Ebola vaccine candidate developed by GlaxoSmithKline and the National Institutes of Health effectively jump - starts the immune system with few side effects, researchers report January 28 in the New England Journal of Medicine.

Gary Nabel, a molecular virologist with the University of Michigan Medical Center in Ann Arbor, and Anthony Sanchez, a virologist at the U.S. Centers for Disease Control and Prevention (CDC) in Atlanta, created their candidate vaccine from snippets of the Ebola virus's DNA.

With a better understanding of how the networks of the body's immune system respond to the disease, researchers could be more selective in the vaccine candidates that they invest time and money in developing.

A single immunization with the vaccine candidate produced strong immune responses and prevented the virus from infecting mice at all.

«New Zika vaccine candidate protects mice and monkeys with a single dose: Results from study highlight the promise of mRNA - based vaccines and therapies.»

Johns Hopkins Bloomberg School of Public Health researchers say a new candidate vaccine against respiratory syncytial virus (RSV) made with a weakened version of the virus shows great promise at fighting the disease, the leading cause of hospitalization for children under the age of one in the U.S.

And, there are no approved Zika vaccines, although the US government is partnering with pharmaceutical companies to develop candidates.

«Nevertheless,» they state, «the model provides a useful perspective on how vaccine properties and strategic choices affect the relative size and severity of projected epidemics,» and conclude that, «a vaccine like the Sanofi - Pasteur candidate can be an effective tool for reducing the dengue burden, although a vaccine with waning efficacy would require a booster program.»

«We learned in this study that grabbing hold of these glycans can be a very important early step in an effective immune response to HIV, and with this knowledge, we believe we can design better candidate vaccines,» said principal investigator Dennis R. Burton, professor of immunology and microbiology at TSRI.

«You certainly can't do a $ 100 million study for every candidate vaccine that appears safe and immunogenic,» says Mark Mulligan, a molecular virologist who heads the vaccine center at Emory University in Atlanta and does human challenges with norovirus and tuberculosis.

Now, the NIAID scientists have improved on their original vaccine with a new candidate that delivers AMA1 protein together with part of a second parasite protein called RON2.

Finally, Kurtis and colleagues used the antibody to develop a vaccine candidate that they gave to mice infected with a particularly lethal form of malaria.

MedImmune, a Maryland company, created the live attenuated candidate H7N9 vaccine as part of a cooperative research and development agreement with NIAID.

Injecting rabbits with a vaccine candidate that contained the protein fragment without the sugar group resulted in antibodies that primarily bound to gp120 from only one HIV strain.

The researchers» next steps will be to conduct longer - term studies in combination with other vaccine candidates, hone in on what areas of gp120 the antibodies are binding to and determine how they can increase the antibodies» effectiveness at neutralizing HIV.

«Our findings support PfSEA - 1 as a potential vaccine candidate, and we are confident that by partnering with our colleagues at the National Institutes of Health and other researchers focused on vaccines to prevent the parasites from entering red blood cells, we can approach the parasite from all angles, which could help us develop a truly effective vaccine to prevent this infectious disease that kills millions of children every year.»

«This would allow vaccine candidates to be tested very early and very quickly,» he told VOA, «with rapid turnaround and reporting of results to either advance a vaccine candidate or tell scientists they need to go back and look for other candidates.»

For influenza we offer the ferret model, the «gold standard» for infections with human influenza viruses, which will be used to assess the efficacy of vaccine candidates.

TNA8: BPRC will provide access to macaques for immunogenicity / adjuvanticity evaluation of vaccine candidates for malaria, tuberculosis, HIV, influenza, West Nile virus or dengue virus, with up to three (prime - boost) immunisation events.

EVI is now embarking on vaccine candidates for other diseases of poverty in line with its wider mandate.

In WP7, iBET will be involved in activities connected with mammalian and insect cell expression platform screening, and small - scale production and purification of candidate vaccines.

W. Bogers: PhD in immunology and 20 years of experience with NHP models for the preclinical evaluation of HIV vaccine candidates as well as testing antivirals.

A Phase Ia Study to Assess the Safety and Immunogenicity of New Malaria Vaccine Candidates ChAd63 CS Administered Alone and with MVA CS.

These proteins can be comparatively tested to identify the most promising vaccine candidates, and to understand how the parasite interacts with the human host and cause disease.

Vaccine studies in infants < 6 mo with novel vaccine candidates have generally demonstrated poor immunogenicitVaccine studies in infants < 6 mo with novel vaccine candidates have generally demonstrated poor immunogenicitvaccine candidates have generally demonstrated poor immunogenicity (90).

One potential use of the vaccine candidate Stamatatos is developing would be to combine it with this or other vaccine candidates, adding to the effect of each.

In parallel, scientists with the P5 have been developing, analyzing and selecting protein components of the vaccine candidates for use in planned studies.

Four candidate vaccines for humans with or without alum adjuvant were evaluated in a mouse model of SARS, a VLP vaccine, the vaccine given to ferrets and NHP, another whole virus vaccine and an rDNA - produced S protein.

Before joining IDRI, Tracey worked as a Protocol Development Manager with the HIV Vaccine Trials Network at the Fred Hutchinson Cancer Research Center where she led multi-disciplinary teams in the design and implementation of clinical trials evaluating candidate HIV and tuberculosis vaccines.

Here we report the use of a liposomal vaccine for the generation of a monoclonal antibody with particular characteristics that makes it a valuable tool for fundamental studies as well as a candidate antibody for diagnostic and therapeutic applications.

As part of this upcoming study, some Ugandan volunteers from the 2009 DNA study will receive a boost, or additional injection, with the new vaccine candidate to explore a more long lasting effect of vaccination.

Recognizing that communicable diseases and neglected tropical diseases disproportionately affect countries with evolving healthcare systems, Takeda is collaborating with partners to expedite access to its potentially life - saving vaccine candidates, which address some of today's most challenging infectious diseases.

A004 is a phase II study of an HIV candidate vaccine Ad26 prime with MVA and protein boost funded and sponsored by Janssen, a division of J&J.

MHRP scientists, working with NIAID, have developed an attenuated viral vector — modified vaccinia Ankara — vaccine candidate, MVA - CMDR (HIV - 1 CM235 env / CM240 gag - pol).

Here, we analyze transcriptional responses after vaccination with Ty21a or vaccine candidate, M01ZH09.

Glenda Gray, executive director of the Wits Health Consortium's perinatal HIV research unit in South Africa, presented data today at the HIV R4P conference in Cape Town indicating that the prime - boost vaccine candidates initially tested in the RV144 trial in Thailand — the only HIV vaccine trial to date to show any efficacy — induced cross-clade immune responses in a Phase I safety trial conducted in South Africa, with immunogenicity similar to or greater than that of the responses induced in Thai volunteers.

RH5 is a leading subunit vaccine candidate because anti-RH5 antibodies inhibit parasite growth and the interaction with its erythrocyte receptor basigin is essential for invasion.

Ownership of vaccine candidates and biomarkers and any intellectual property rights remain with researchers and vaccine developers.

iBET will be involved in activities related with GMP - directed evaluation of vaccine candidate production processes, production scale - up for vaccine candidates, definition of specifications for pilot - scale production, product stability testing and delivery for GLP toxicology studies, and evaluation of development, manufacturing and finishing documentation.

There is no evidence in Marek's disease that vaccine breakthrough by more virulent strains has anything to do with overcoming strain - specific immunity (e.g., epitope evolution); genetic and immunological comparisons of strains varying in virulence suggest that candidate virulence determinants are associated with host — cell interactions and viral replication, not antigens [19].

We partner with government, academic, and industry experts to explore multiple vaccine concepts simultaneously and advance only the most promising candidates.

Research & Development IAVI worked with the Japanese biotech company DNAVEC, based in Tsukuba City, to jointly develop an AIDS vaccine candidate based on its novel Sendai vector technology.

We also work with partners to develop tools and processes to evaluate vaccine candidates.

These events relate primarily to settlement of VaxGen's obligations under its lease of facilities in South San Francisco, and to the potential award of a procurement contract to Emergent BioSolutions (NYSE: EBS) by the U.S. Government for which VaxGen is eligible to receive milestone and royalty payments in connection with Emergent BioSolutions» May 2008 acquisition of VaxGen's recombinant protective antigen (rPA) anthrax vaccine product candidate and related technology.