Sentences with phrase «vaccine designed in»

Vaccine Design In this effort, many LJI scientists conduct pre-clinical studies relevant to design and optimize vaccines to combat infectious diseases like tuberculosis or dengue virus.

Not exact matches

In 2015, researchers at the University of Washington's Cancer Vaccine Institute published a study on designing vaccines to prevent breast cancer.

To mimic a booster shot, the microspheres had to be designed to survive for months in the body, then quickly release vaccine.

In the world of vaccine development, 3 1/2 months from design to injection is «warp speed,» says vaccine researcher Nelson Michael of the Walter Reed Army Institute of Research in Silver Spring, MdIn the world of vaccine development, 3 1/2 months from design to injection is «warp speed,» says vaccine researcher Nelson Michael of the Walter Reed Army Institute of Research in Silver Spring, Mdin Silver Spring, Md..

The vaccine tested in Cape Town in 2013 was MVA 85A, a modification of the cowpox vaccine designed to express a major protein of the TB bacterium.

Now that boost in Zika - linked Guillain (GBS) is stoking concerns that a vaccine designed to protect patients against Zika could inadvertently provoke more cases of the autoimmune condition.

These findings provide insights for the design of vaccines that can «kick - start» and then shape the maturation of broadly neutralizing antibodies in HIV uninfected individuals, to provide protection from HIV exposure.

Studies that compare flu alterations in multiple people won't immediately tell researchers how to design vaccines, she says, but could point to parts of the virus for further investigation.

«Our ability to control these reactions and use them to form a response to the vaccine will be critical in designing the next generation of vaccines,» Kemble says.

But designing solutions to real - world vaccine problems requires him to answer questions that he might not have pursued in the past: «What's the best microRNA to choose?

To be sure, scientists have zeroed in on some promising vaccine - adjuvant combinations, and a few well - designed trials are now under way.

Most attempts have been vaccines designed to make us produce antibodies, aimed not at flu's surface proteins, but at internal proteins that are the same in all flu viruses.

To create a new dengue virus vaccine, Stefan Metz, Shaomin Tian in the laboratories of Aravinda de Silva, Chris Luft and Joe DeSimone at the University of Carolina, Chapel Hill, USA designed nanoparticles of various shapes and sizes using Particle Replication in Non-wetting Template (PRINT) technology.

Every year, public health officials survey the three flu subtypes circulating in humans and design a vaccine for the next winter season that covers them all.

«We think we can use our molecular, rational design approaches to make a better flu vaccine for people who really need it,» says study leader Andrew Pekosz, PhD, an associate professor in the Department of Molecular Microbiology and Immunology at the Bloomberg School of Public Health.

Understanding how the virus operates offers a pathway to designing antiviral drugs as well as new vaccines to control bluetongue and related viral infections in animals and humans.

Most cancer vaccines developed to date have been designed to recognize and attack a specific known molecule — such as a cell - surface receptor — that is likely to be found on cancerous cells in any patient with that type of tumor.

Using the findings from this study, the team has designed vaccine immunogens to selectively trigger the cooperating antibody - producing B cells to cooperate to make broadly neutralizing antibodies in a manner that mimics broadly neutralizing antibody development in natural HIV infection.

It is designed to learn more about the immune responses to the vaccine in different populations.

CTL119 manufacturing begins with a patient's own T cells, some of which are removed and then reprogrammed in Penn's Clinical Cell and Vaccine Production Facility with a gene transfer technique designed to teach the T cells to target and kill tumor cells.

This seminal finding led to his recognition as an important scientist in vaccine design, and to his inclusion as a T cell expert in the CHAVI - ID vaccine consortium.

Ferguson's team is calling for trials of Zika treatments and vaccines to be designed so that even if the epidemic burns out, they are ready to kick in quickly should Zika roar back again.

The heart disease shot Some of the new therapeutic vaccines are actually designed to attack the body, albeit in a selective way.

Scientists say the key may be in the way the vaccine is designed.

Researchers working on cancer vaccines may need to take account of these interactions in designing their treatments if they are ever to prove effective.

«Engineers design programmable RNA vaccines: Tests in mice show the vaccines work against Ebola, influenza, and common parasite.»

Taking a slightly different route, Aviron, a biotech company in Mountain View, California, designed a vaccine based on a live, inactivated virus that could be squirted into the nose as a fine mist.

«We realized that might be an approach that you could try to copy in a vaccine — design a vaccine molecule that binds to albumin and hitchhikes to the lymph node,» Irvine says.

«But it is a meaningful approach in protein design that could be given as a vaccine so that it triggers an immune response.»

Kang's primary research focuses on designing and developing effective vaccines against viral diseases such as influenza virus and RSV, but he partnered with a university and research institutes in South Korea that wanted international collaborative projects to study if ginseng can be used to improve health and protect against disease because of the potential benefit in fighting these viruses.

«We learned in this study that grabbing hold of these glycans can be a very important early step in an effective immune response to HIV, and with this knowledge, we believe we can design better candidate vaccines,» said principal investigator Dennis R. Burton, professor of immunology and microbiology at TSRI.

Defining how to safely replicate these attributes in HIV - uninfected vaccine recipients may lead to better designed experimental vaccines to protect against HIV.

This approach represents a departure from traditional vaccine designs, which have been developed and tested against HIV in vulnerable populations since the mid-1980s without success.

However, bnAbs are found in only a minority of infected people, in quantities too small to clear the virus, so Burton and other researchers are now trying to design vaccines to elicit these bnAbs in numbers large enough to provide effective protection.

Identifying those two molecular targets could help in the design of better vaccine strategies and tumor immunotherapies.»

PEOPLE who are allergic to cats may find that relief is on the way in the form of a vaccine designed to retrain the sufferers» immune systems.

«It is likely to be part of the mechanism for changing the functions of other immune cells, and the insight may help in designing vaccines.»

The ability to design new protein nanostructures could have useful implications in targeted delivery of drugs, in vaccine development and in plasmonics — manipulating electromagnetic signals to guide light diffraction for information technologies, energy production or other uses.

Global vaccine experts and officials from all 26 African «meningitis belt» countries have convened in Addis Ababa, Ethiopia to celebrate one of Africa's biggest public health achievements — the introduction of a vaccine, MenAfriVac ®, designed, developed, and produced for use in Africa, that in five years of use has nearly eliminated serogroup A meningococcal disease from meningitis belt countries and is now being integrated into routine national immunization programs.

In December 2009, the U.S. Food and Drug Administration licensed trivalent inactivated influenza vaccine — Sanofi Pasteur's Fluzone High - Dose — specifically designed for people 65 years and older.

But the hope, he says, is that ImmunoMap may one day be helpful in designing vaccines and engineered T - cells for cancer treatment.

«Results from a former AIDS vaccine study have shown that in a worst case scenario, immunization against HIV could enhance infection,» says Christiane Stahl - Hennig, who designed the project in cooperation with the former DPZ employee Sieghart Sopper.

Although reanalysis of the available evidence is important, the ability to properly control for bias and confounding [factors that can influence outcomes] in observational studies is often limited, and without randomized controlled trials specifically designed to test the hypothesis, the issue of nonspecific effects of vaccines may remain subject to continuing debate.»

The study focused on a flu vaccine designed to protect against an unusual strain that originated in pigs and caused a pandemic in 2009.

«I mean, we're working in things like vaccine design and computational biology, quantum computing.»

Vaccine therapies are designed to strengthen the body's immune defenses and are typically given in the arm or leg.

Researchers at the University of Maryland and Duke University have designed a novel protein - sugar vaccine candidate that, in an animal model, stimulated an immune response against sugars that form a protective shield around HIV.

«Our vaccine was made possible by combining a wide range of biomedical expertise that thrives in Boston and Cambridge,» said Mooney, who specializes in the design of biomaterials for tissue engineering and drug delivery.

«New findings to help HIV scientists establish «template» for potent antibodies: Natural - infection studies in Africa and India continue to inform HIV vaccine design.»

Led by University of Texas Austin researcher Dr Steve Bellan, and in collaboration with the U.S. Centers for Disease Control and Prevention (CDC), the study on the design of CDC's vaccine trial in Sierra Leone is published in The Lancet Infectious Diseases.