That could be a serious concern
for vaccine developers, says John LaMontagne, director of the division of Microbiology and Infectious Disease at the National Institute of Allergy and Infectious Diseases.
Broadly neutralizing HIV antibodies have been isolated from chronically infected people, giving
HIV vaccine developers hope that they could stimulate production of such antibodies in healthy people as protection against the virus.
But people living in malaria - endemic areas do naturally what
vaccine developers hope to induce with an injection: They gradually build up immunity to the disease.
Currently, there are three phase - three clinical trials for a dengue vaccine and UNC is collaborating
with vaccine developers to understand data from these trials, de Silva said.
That means that the viral proteins, including those that alert our bodies to an infection, constantly reinvent themselves, threatening our immune systems and
frustrating vaccine developers.
Moreover, getting a better picture of what the virus looks like and understanding its properties through animal testing and studying patients» blood might help
vaccine developers pinpoint specific issues, says Pei - Yong Shi, a virologist at The University of Texas Medical Branch at Galveston.
The so - called «human challenge model» has a long and checkered past that began with 18th century experiments by
smallpox vaccine developer Edward Jenner and later fell under intense scrutiny when they were conducted by Nazi doctors, military researchers, and academic scientists working with prisoners.
Techniques that neutralize viruses which have LEGO - style capsids often don't work on Epstein — Barr, herpes or Kaposi's sarcoma viruses, much to the disappointment of
many vaccine developers.
Malaria vaccine developers have been fortunate to have access to a human challenge model — known as controlled human malaria infection or CHMI — to evaluate the protective efficacy of pre-erythrocytic vaccines in early clinical trials.
Even so, the complex vaccine will be expensive by developing world standards, and its cost - effectiveness is a major issue
for vaccine developers and public health experts, says Scott Filler of the Global Fund to Fight AIDS, Tuberculosis and Malaria.
Of special interest to
HIV vaccine developers are sub-Saharan African populations, who have the largest prevalence of HIV worldwide.
«Currently, there are three phase - three clinical trials for a dengue vaccine and UNC is collaborating
with vaccine developers to understand data from these trials.»
The Gynecologic Oncology Group study is sponsored
by vaccine developers, Advaxis, Inc., a Princeton, New Jersey - based company that focuses on immunotherapies to combat cancer.
Vaccine developers for these diseases will probably also have to look in unusual places for answers.
And the skeptics point out that
vaccine developers have had little success against pathogens like HIV that routinely outwit the immune system — the malaria parasite, hepatitis C virus, and the tuberculosis bacillus are prime examples.
Vaccine developers have agreed that so - called monovalent vaccines that target only the Zaire species should be deployed in West Africa.
Vaccine developers are trying to improve vaccines for transplant recipients and other people with a weak immune system, and the samples used in this study came from a clinical trial of different versions of a flu vaccine in patients on immune - suppressive drugs.
Vaccine Developers «Chlamp» Down on Chlamydia.
The Bancroft group does not generate themselves these candidates, but it is an independent testing centre for
vaccine developers, providing valuable head to head comparisons of candidates from across laboratories in the consortium.
Ownership of vaccine candidates and biomarkers and any intellectual property rights remain with researchers and
vaccine developers.
It's
the vaccine developers» best guess as to whether or not the current infective organisms are the same strain as the vaccine, a process similar to what happens the human flu vaccines.