Sentences with phrase «vaccine efficacy»
"Vaccine efficacy" refers to how well a vaccine works in preventing a specific disease or infection. It measures the ability of the vaccine to protect individuals from getting sick when exposed to the disease. Higher vaccine efficacy means that the vaccine is more effective in preventing the illness. Full definition
These individuals are particularly susceptible to the more serious effects of influenza infection, so improving vaccine efficacy in these people would be a real plus.
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In the new study, the method accurately predicted vaccine efficacy rates for more than 40 years of flu records.
We're trying to better understand the barriers to flu vaccination, along with vaccine efficacy issues.
The Thai Government committed to supporting future HIV vaccine efficacy studies and establishing a flexible biologics manufacturing capability that could support HIV vaccine production in Thailand.
2016 — New HIV vaccine efficacy study (HVTN702) begins in South Africa that builds on RV144 — MHRP researchers are part of a team that initiated new trials to build on the success of RV144
Therefore, good vaccine antigens should also display good vaccine efficacy against highly virulent Mtb strains.
Randomized, Double - Blind Evaluation of Late Boost Strategies for HIV - Uninfected Vaccine Recipients in the RV144 HIV Vaccine Efficacy Trial.
However, if vaccine efficacy wanes after administration, the researchers found that there could be years with larger epidemics than would occur without any vaccination (the baseline scenario), and that vaccine booster doses are necessary to prevent this outcome.
Sanjay Gurunathan from Sanofi Pasteur, manufacturer of one of the vaccines used in RV144, said a new partnership of the US National Institute of Allergy and Infectious Diseases, The Bill & Melinda Gates Foundation, HIV Vaccine Trials Network, US Military HIV Research Program (MHRP), and Sanofi Pasteur — known as the Pox Protein Public Private Partnership, or P5 — will aim to increase vaccine efficacy from the 31.2 percent of the RV144 trial to 50 percent.
«A new approach to predict evolution of influenza viruses can enhance vaccine efficacy.»
SN: You're suggesting combining the two earlier AIDS vaccine efficacy studies that have been done?
The HVTN is an international collaboration that conducts all phases of clinical trials, from evaluating experimental vaccines for safety and the ability to stimulate immune responses, to testing vaccine efficacy.
In addition, the Fletcher group investigates immunity using the mouse model and aims to develop animal models of TB disease better able to predict TB vaccine efficacy in clinical trials.
developing and implementing new or improved preclinical models with greater relevance to the target product profile (TPP) and clinical vaccine efficacy
While other papers have examined these mutations using expensive and time - consuming experiments on live ferrets and laboratory cell cultures, Deem and Melia Bonomo used the pEpitope method to rapidly calculate how much the egg - passage mutations would decrease vaccine efficacy in humans.
Unintended effects of this process have reduced vaccine efficacy against H3N2 the past two years, Deem said.
Vaccine efficacy refers to the percentage of reduction in disease incidence in a vaccinated group compared to an unvaccinated group.
«But this is a promising first step in understanding the mechanisms by which memory cells form, which ultimately will play a role in improving vaccine efficacy.
«This study evidences protection for an elderly population for whom vaccine efficacy has been questioned,» he said.
Last year the flu vaccine efficacy was very low because the HA in the vaccine didn't match the HA on the virus that was circulating, so the antibodies did not recognise the virus.
Correlates of Protection against Influenza in the Elderly: Results from an Influenza Vaccine Efficacy Trial.
A private - public partnership called the AIDS Vaccine Efficacy Consortium (AVEC) was formed in 2012 to accelerate the development and testing of a pox - protein HIV vaccine prime - boost regimen in Thailand.
Another collaborative vaccine efficacy trial began last month in South Africa.
The Dockrell group is focusing on genes and cells that play a crucial role in polarisation of the immune responses and that could affect vaccine efficacy.
No comparative conclusions about vaccine efficacy can be made, and efficacy was not a priority or an endpoint in this study.
Before the age of approximately 8 weeks, puppies receive antibodies from their mothers» milk, and vaccinating before this time can result in lesser vaccine efficacy.
The latest pEpitope study, which is available online this week in Clinical Infectious Diseases, suggests pEpitope is a more accurate predictor of vaccine efficacy than long - relied - upon ferret tests, particularly for data gathered in the past decade.
Recently, monkey studies testing vaccine regimens different from those in RV144 have supported the notion that enhancing protective antibody activity may increase vaccine efficacy.
«We believe that our results and methodology could further improve vaccine strain selection process and, thereby, enhance vaccine efficacy.
The Fletcher group investigates the impact of host - immunity on TB vaccine efficacy.
«Although data clearly indicate better immune responses and vaccine efficacy against both genital warts and cervical dysplasia when vaccination occurs before age 14, this study suggests that HPV vaccination may be effective in reducing abnormal Pap test results even after sexual debut,» explained co-author Rebecca Perkins, MD, MSc, assistant professor of Obstetrics and Gynecology at Boston University School of Medicine and a gynecologist at Boston Medical Center.
Results from the RV144 trial, reported in 2009, provided the first signal of HIV vaccine efficacy: a 31 percent reduction in HIV infection among vaccinees.
Secondly, the group provides standard models of vaccination and pulmonary challenge with virulent M. tuberculosis in mice to study vaccine efficacy in vivo.
«Vaccine efficacy is known to decline in old age, so we're hopeful that this novel application of the drug could help make vaccines more effective in older people,» said co-author Dr Veronique Birault (Francis Crick Institute).
In a year, the study team will have finished collecting and processing the vaccine efficacy data for clinical and severe malaria in the younger group.
Then they can change parameters for each scenario — adjusting variables including disease biology and virulence — to help determine action plans for things like vaccine stockpiles, vaccine efficacy, and deploying field personnel.
In the group whose mothers had been vaccinated against flu, vaccine efficacy was nearly 70 percent in the first four months after birth.
As they describe, their «ability to forecast vaccination impact is primarily limited by the current uncertainty regarding whether and how vaccine efficacy wanes over time and how vaccine efficacy is affected by prior infection.»
Vaccine efficacy was set at an average of 60 % (actual numbers depended on the different virus subtypes and on whether a person had been exposed due to a prior natural infection) based on recent phase III trial results for the Sanofi - Pasteur vaccine that had shown moderate effectiveness.
The trial is sponsored by Global Health Innovative Technology Fund (Japan) and results of vaccine efficacy will be available in late 2018.
For vaccine efficacy, it really doesn't look so good.
It's also unclear whether these differences translate into differences in vaccine efficacy.
As AMA1 malaria vaccines are evaluated in efficacy trials, the impact of genetic diversity of parasite antigens on vaccine efficacy is likely to emerge as a critical problem requiring integration of methods and concepts drawn from molecular epidemiology, molecular evolution, immunology and structural vaccinology [9], [13].