Sentences with phrase «vaccine strain»

Next, the researchers wanted to see if their technology could tackle some of the worst - growing vaccine strains in history.

One problem is that there are several vaccine strains used to provide protection for the various diseases vaccines protect against.

The sequences obtained from the patients with ulcerative colitis and children with autism were consistent with vaccine strains.

In addition, PCR assays also detect vaccine strains of FHV - 1.

«We believe that our results and methodology could further improve vaccine strain selection process and, thereby, enhance vaccine efficacy.

The transmissible viruses were sensitive to the antiviral drug oseltamivir and reacted well with antisera raised against H5 influenza vaccine strains.

For 70 years most flu vaccine strains have been grown in fertilized chicken eggs because egg growth incites excellent yield.

Dr. Glass was also leader of the JCVI project that rapidly made synthetic influenza virus vaccine strains in collaboration with Novartis Vaccines and Diagnostics, Inc., and Synthetic Genomics, Inc..

Not all vaccines are created equal, Hancock explains, so it pays to be certain you are using a vaccine with up - to - date and relevant vaccine strains.

This means it might be necessary to develop several different vaccine strains to ensure one provoked sufficient response.

Pigs and humans need several doses of killed influenza vaccine in order to provide immunity: a «priming» dose is followed by booster vaccinations with the same or very similar vaccine strains.

With the recent sequencing of the M. tuberculosis genome, the human pathogen, Marcel Behr and his colleagues at Stanford University in California and McGill University in Montreal, Canada, decided to compare genes present in TB vaccine strains around the world.

As a result, HA antibody levels have traditionally been used to guide vaccine strain selection and to infer how effective that vaccine might be against circulating viruses until field studies are available.

In the new study, scientists built upon previous discoveries that a safe, non-reproducing vaccine strain of T. gondii could cure mice of several types of solid tumors, and identified which parasite proteins and which immunological pathways are required to break immune tolerance.

They will try to improve on that with new vaccine strains, but even if they fail, U.S. pandemic planning has incorporated such setbacks, Schuchat told reporters.

As a final confirmation of the compound's potential to stop a virus from spreading, they tested it against an actual virus: the nonpathogenic vaccine strain of the Junin virus.

In a 4 January announcement, the WHO called for oral polio vaccine containing the polio strain type 2, one of the Sabin vaccine strains, to be phased out — perhaps in as little as two years.

While this year's vaccine is a much better match to the circulating seasonal strains of influenza, the shifty nature of the virus and the need to pick the viruses used to make global vaccine stocks well before the onset of the flu season can make vaccine strain selection a shot in the dark.

«It is very closely related to other domesticated strains that have been used by the Soviets and Chinese as vaccine strains,» Keim says.

The team found 26 polio vaccine strains in sewage and three in river water.

The extracellular domain of the H5 or H7 protein of the respective avian influenza viruses was transplanted into the Newcastle disease virus vaccine strain LaSota in order to make the vaccine constructs.

Hybridising between live vaccine strains, or a live vaccine and wild viruses, is less predictable.

Browning and colleagues have now sequenced the new viruses and found that in each case they arose when the European vaccine strain acquired genes from the Australian vaccine viruses.

Rotavirus - specific cytotoxic T lymphocyte response of mice after oral inoculation with candidate rotavirus vaccine strains RRV or WC3.

A paper published recently showed that the H3N2 vaccine strain with egg - based mutations was less able to mount an immune response against the circulating H3N2 strain.

This cell death is induced by many rough attenuated Brucella strains, including Brucella cattle vaccine strain RB51, B. abortus wboA mutant VTRA1, and B. suis wboA mutant VTRS1.This cell death is prevented by wild type virulent Brucella in infected macrophages, but not in dendritic cells.

This practical benefit may be attributed to the temperature - sensitive FELOCELL FIP vaccine strain, which replicates in the upper respiratory tract but does not spread systemically at 39 °C, the cat's body temperature.

Rath, B.A., et al Persistent Bordetella bronchiseptica Pneumonia in an Immunocompetent Infant and Genetic Comparison of Clinical Isolates with Kennel cough Vaccine Strains Clinical Infectious Diseases, 2008

«It is still worthwhile to encourage the immune system to make a greater quantity of antibodies, even if their quality does not rise appreciably, and the value of vaccination may be greater when the flu vaccine strains are not identical to those used in previous seasons» vaccines,» he says.

The head region of HA is constantly changing, which is why influenza vaccine strains must be updated each year.

«There were a couple of these in the vaccine strain the past two seasons that wound up making it a little bit different from the actual circulating virus strain.»

In the coming months, scientists will have to evaluate the trial's full data to determine why the vaccine failed: Were the infecting viruses too different from the vaccine strain to offer resistance?

Current flu vaccines are only effective against virus strains that match the vaccine strains.

The researchers now aim at finding an optimal combination of vaccine strains, which would protect against H3N2 viruses from both humans and swine and control (reverse) zoonotic transmission of influenza viruses.

However, some early indicators from China suggest that the main H3N2 in circulation there may be a mismatch with the vaccine strain.

These rare VDPVs arise when a virus used in the live vaccine reverts from its weakened form and regains its virulence — a danger when vaccination rates are low, as they are in both places, allowing the vaccine strain to circulate and accumulate genetic mutations.

A possible problem facing a human vaccine is that some people already have an immune response to some strains of adenoviruses, which would reduce the body's response to the vaccine strain.

This could be due to antigenic mismatch between the circulating influenza viruses and the vaccine strains recommended by the WHO.

Only 13 base pairs differ between the Sverdlovsk strain and its likely common ancestor with the vaccine strains.

The new sugar molecule hinders the virus's ability to grow in eggs — so once the vaccine strains are put into eggs, they ditch it.

A recent study from Australia, which is just finishing its flu season and used the vaccine strains that the U.S. is now using, suggests the H3N2 component of this season's vaccine is only 10 percent effective.

The vaccine used during the 2012 — 13 flu season in Canada did not work very well, despite the fact that the circulating flu viruses had not seemingly changed much after the vaccine strains had been chosen.

Two studies now suggest a new reason for the problem: The vaccine strain mutates during the manufacturing process in ways that cause mismatches with real circulating flu strains.

«This work shows that with live vaccines, we need to pay attention to the evolution of the vaccine strains themselves,» says Andrew Read at the University of Pittsburgh in University Park, an expert in pathogen evolution who was not involved in the research.

The virus itself will continue to mutate from year to year — a process referred to as antigenic drift — and over time it becomes less well matched to the vaccine strain, meaning that the antibodies you generate from getting the vaccine may be less effective in neutralizing the circulating virus.

So, due to natural changes in the virus as it evolves, as well as due to mutations that may be caused by growing the vaccine strain, the circulating virus and the vaccine become less well matched over time.