2017 — Began a new multi-site Phase 2 Ebola
vaccine study at MHRP sites in Africa evaluating a prime - boost regimen in both healthy and HIV - infected volunteers (Ad26.ZEBOV from J&J; MVA - BN - Filo from Bavarian Nordic)
Not exact matches
In 2015, researchers
at the University of Washington's Cancer
Vaccine Institute published a
study on designing
vaccines to prevent breast cancer.
A recent comparative
study of worldwide military and social spending indicated how
at present 1.3 million dollars per minute on average are spent for military purposes; during the same minute 30 children die for lack of food or simple
vaccines (WMSE).
Not only would the new method, tested only in mice, be more convenient but also more effective than the flu shot or nasal spray, according to a
study at the International
Vaccine Institute in Seoul.
Professor David Salisbury, director of immunisation
at the DoH, said: «It's natural for parents to worry about the health and well - being of their children and I hope that this
study will reassure them that there is no evidence linking the MMR
vaccine to autism.»
In the new
study, researchers
at the NIAID used a virus - like particle
vaccine cocktail that expressed a handful of different subtypes of a key surface protein of the influenza virus: hemagglutinin H1, H3, H5 and H7.
A new
study shows pregnant women who get flu shots regularly have a weaker peak antibody response to the
vaccine than women who don't get them regularly, though mothers and their babies in both groups were well - protected
at the time of delivery.
Dr Alice Forster,
study author and Cancer Research UK scientist
at University College London, said: «Although around 87 per cent of girls in the UK do have the
vaccine it's concerning to see that some girls from some ethnic minority groups feel they don't need to have it.
At Kaiser Permanente Northern California, which conducted the
study, the first use of the new DTaP was in the
vaccine's fifth booster shot in 1991, followed by its use for the fourth booster the next year.
Moreover, getting a better picture of what the virus looks like and understanding its properties through animal testing and
studying patients» blood might help
vaccine developers pinpoint specific issues, says Pei - Yong Shi, a virologist
at The University of Texas Medical Branch
at Galveston.
Sun's
study found that children given the
vaccine had a six-fold increased risk of a febrile seizure on the day of their first vaccination (given
at three months) and a four-fold increased risk on the day of their second vaccination (given
at five months).
For thimerosal, the IOM looked
at five
studies, examining populations in Sweden, Denmark, the United Kingdom, and the United States (
studies that
vaccine critics contend were flawed).
In the
study, a tipping point represented the point
at which
vaccine coverage declines dramatically due to spreading fear, which could cause large disease outbreaks due to a loss of population immunity.
Although previous
studies of similar nanoparticles have found an effect of nanoparticle shape and size on antibody responses, such a trend was not seen
at significant levels for the DENV2 - E
vaccine.
«Based on epidemiological
studies, the 9vHPV
vaccine could prevent approximately 90 percent of cervical cancer, 90 percent of HPV - related vulvar and vaginal cancer, 70 to 85 percent of high - grade cervical disease in females, and approximately 90 percent of HPV - related anal cancer and genital warts in males and females worldwide,» explained Anna R. Giuliano, Ph.D., Director of the Center for Infection Research in Cancer
at Moffitt.
«We think we can use our molecular, rational design approaches to make a better flu
vaccine for people who really need it,» says
study leader Andrew Pekosz, PhD, an associate professor in the Department of Molecular Microbiology and Immunology
at the Bloomberg School of Public Health.
The researchers, including those from Moffitt Cancer Center, published the final results of a
study showing the newest
vaccine is highly effective
at preventing HPV infection and disease.
The
study, which will not be completed for
at least five years, will evaluate whether the
vaccine prevents tumor recurrence rather than causing shrinkage.
The
study involved 10 275 healthy children aged 2 to 14 years who were randomly assigned to receive three injections of the CYD - TDV
vaccine (6851) or a placebo (3424)
at 0, 6, and 12 months, and followed for up to 2 years.
«It's a novel strategy, and it works beautifully,» said senior investigator Harvey M. Friedman, MD, a professor of Infectious Diseases
at Penn. «I know of no other HSV2
vaccine candidate with published results that are as promising as this
study.»
Vaccines are successful in preventing pandemic flu and reducing the number of patients hospitalised as a result of the illness, a
study led by academics
at The University of Nottingham has found.
«What this
study tells us is that if more and more people choose not to get a
vaccine,» says Paul Offit, director of the Vaccine Education Center at The Children's Hospital of Philadelphia, «then you'll have bigger and bigger outbreaks.
vaccine,» says Paul Offit, director of the
Vaccine Education Center at The Children's Hospital of Philadelphia, «then you'll have bigger and bigger outbreaks.
Vaccine Education Center
at The Children's Hospital of Philadelphia, «then you'll have bigger and bigger outbreaks.»
During the 2012 - 2013 season, when H3N2 viruses were dominant, the high - dose flu
vaccine was 36 percent more effective
at preventing deaths in the Medicare beneficiaries
studied, compared to the standard - dose
vaccine.
«This
study demonstrates that despite high rates of Tdap vaccination, the growing number of adolescents who have received only the newer acellular pertussis vaccines continue to be at higher risk of contracting whooping cough and sustaining epidemics,» said lead author Nicola Klein, MD, PhD, co-director of the Kaiser Permanente Vaccine Study Ce
study demonstrates that despite high rates of Tdap vaccination, the growing number of adolescents who have received only the newer acellular pertussis
vaccines continue to be
at higher risk of contracting whooping cough and sustaining epidemics,» said lead author Nicola Klein, MD, PhD, co-director of the Kaiser Permanente
Vaccine Study Ce
Study Center.
Many individual
studies have looked
at how effective the available
vaccines were
at preventing illness and hospitalisation caused by the pandemic influenza strain but up until now no - one has summarised all the available data.
For example, a
study just out in The Lancet, funded by the U.S. Food and Drug Administration and focused on Medicare patients, found that the high - dose
vaccine was 22 percent more effective
at preventing flu - related hospital admissions.
«This
vaccine appears to be safe for patients, and elicits a broad anti-tumor immunity — we think it warrants further testing in larger clinical trials,» said
study lead author Janos L. Tanyi, MD, an assistant professor of obstetrics and gynecology
at Penn Medicine.
Studies have shown that flu
vaccines work better
at protecting against influenza B or influenza A H1N1 viruses than influenza A H3N2.
The results from the
study could be used to help public health officials to plan a more effective response to future pandemics, such as rolling out
vaccines at a much earlier time and targeting specific types of
vaccines at different age groups.
Professor Ajit Lalvani from the National Heart and Lung Institute
at Imperial College London, who led the
study, said: «New strains of flu are continuously emerging, some of which are deadly, and so the Holy Grail is to create a universal
vaccine that would be effective against all strains of flu.»
Last year the National Institutes of Health announced plans to put some 180 ex-Coulston chimps currently housed
at the Alamogordo Primate Facility back in service, to rejoin the roughly 800 other chimps that serve as subjects for
studies of human diseases, therapies and
vaccines in the U.S., which is the only country apart from Gabon to maintain chimps for this purpose.
During the following season (2013 - 2014), when H1N1 viruses dominated and the standard - dose
vaccine had better effectiveness than the previous season, the high - dose
vaccine was not significantly better
at preventing deaths among the Medicare patients
studied.
These findings, which appear in an early online edition of
Vaccine, confirmed the expected results, said Geoffrey Gorse, M.D., professor of internal medicine in the division of infectious diseases
at Saint Louis University and the
study's lead author.
«We are pleased to have demonstrated such a potent and durable immune response to the
vaccine,» said the
study's lead author, Sita Awasthi, PhD, a research associate professor of Infectious Diseases
at Penn. «If found effective in clinical trials, the
vaccine will have a huge impact on reducing the overall prevalence of genital herpes infections and could reduce new HIV infections as well, especially in high - burden regions of sub-Saharan Africa.»
But influenza
vaccine research completed before that time by Yoshihiro Kawaoka's group
at the University of Wisconsin, Madison, may demonstrate «the risk of curtailing so - called [GOF]
studies,» wrote Jon Cohen in a Wednesday ScienceInsider.
In 2011, Science's editors will be watching a smaller detector
at the Large Hadron Collider called LHCb, which will
study B mesons in great detail; new techniques that should lead to the discovery of many more genes contributing to adaptation; an ignited fusion burn
at the National Ignition Facility; broadly neutralizing antibodies, which are capable of disabling a wide range of viral variants; the first plug - in hybrid electric cars whose batteries are charged from a wall socket go on the market; and the results of the first phase III trial of a malaria
vaccine.
«Delivery of the HPV
vaccine in safety - net settings is critically important because uninsured African - American and Hispanic women have higher rates of cervical cancer,» said Dr. Jasmin Tiro, Associate Professor of Clinical Sciences
at UT Southwestern, who led the
study.
«The ability to identify the glycan fingerprint on HIV's glycoprotein will help us develop a
vaccine that matches what is found on the virus,» said James Paulson, Cecil H. and Ida M. Green Chair of Chemistry
at TSRI and co-chair of the Department of Molecular Medicine, who led the
study published in the journal Nature Communications.
«There is a need to understand what's happening with the existing live
vaccine and potentially a need to develop a new one,» said David Topham, Ph.D., Marie Curran Wilson and Joseph Chamberlain Wilson Professor of Microbiology and Immunology
at URMC and author of the
study.
The new research is
at odds with other
studies that cleared the
vaccine of responsibility.
At the time of this
study (2010 - 2011), the
vaccine was only recommended for girls.
A few months later, he was working
at the International Center for Genetic Engineering and Biotechnology (ICEGB) in Delhi,
studying malaria
vaccines.
«Now that we know the mice can be vulnerable to Zika infection, we can use the animals to test
vaccines and therapeutics — and some of those
studies are already underway — as well as to understand the pathogenesis of the virus,» said senior author Michael Diamond, MD, PhD, a professor of medicine
at Washington University.
One goal of the
study is to demonstrate the prevalence of H. influenzae in the region, explains Joel Ward, director of the Center for
Vaccine Research
at the University of California, Los Angeles, and scientific adviser to IVI.
«HPV
vaccines could dramatically reduce the incidence of HPV - associated cancers, but uptake of these
vaccines is far lower than for other routine childhood and teen immunizations,» said Kevin A. Henry, PhD, an assistant professor in the Department of Geography and Urban
Studies at Temple University in Philadelphia and member of Fox Chase Cancer Center's Cancer Prevention and Control program.
«An RSV
vaccine with this M2 - 2 deletion could tip the balance toward a better immune response, which is what we predicted based on earlier laboratory
studies,» says
study leader Ruth A. Karron, MD, director of the Center for Immunization Research and a professor in the Department of International Health
at the Bloomberg School.
The
study included 124 newly diagnosed patients
at 25 clinical trial sites in the U.S. Two - thirds of the patients were treated with ICT - 107, an experimental
vaccine based on immune system cells called dendritic cells that were exposed to six synthetic proteins, or antigens, known to be involved in GBM development.
Heidi Larson is an anthropologist
at the London School of Hygiene and Tropical Medicine who
studies public trust in
vaccines
In a March 2009
study published in Genes and Immunity, researchers
at the National Center for Computational Toxicology compared the genetic signatures of 16 people who experienced smallpox
vaccine side effects, including fever, rashes and enlarged lymph nodes, to 45 people who did not.
Researchers
at the Kaiser Permanente
Vaccine Study Center in Oakland, Calif.,
studied the medical records of mothers who gave birth to babies between 2010 and 2015.