Sentences with phrase «vaccine target as»

Pf RH5 is a high priority vaccine target as it plays an essential and universal role in erythrocyte invasion [53, 57, 61 — 63], yet it is poorly immunogenic in vivo [61], possibly due to its late release onto the merozoite surface during erythrocyte invasion.

«Hepatitis C mutations «outrun» immune systems, lab study shows: Study identifies mutations outside of traditional vaccine targets as barrier to vaccine development.»

Not exact matches

His work indicates that this cell surface marker could serve as a target for a novel brain cancer vaccine or T - cell therapies engineered to recognize and kill tumors carrying that neoantigen.

«Every government initiative, including the HPV [Human papillomavirus] vaccine, will increase [teenage infertility], but as all the targets revolve around pregnancy, no - one in power knows how many young people they are making sterile and nobody cares», it read.

As researchers learn more about genetic profile of various cancers, other work is charging ahead to deliver personalized vaccines targeted to a patient's own tumor cells

Fiers discovered a key protein on the influenza virus that could serve as a target for a universal vaccine; the drug has shown promise in an early clinical trial.

Another possible application for the new machine is generating peptides that could be used as personalized cancer vaccines targeting unique proteins found in individual patients» tumors.

If these test - tube results are confirmed in infected animals and people, the viral proteins could be targets for anti-Ebola vaccines as well as for drugs that treat Ebola infections.

«In addition, this platform can be used to develop safe vaccine candidates for other flaviviruses such as Zika virus, where pregnant women are the target group for vaccination.»

Scientists had known that the hemagglutinin stem, or stalk, isn't as apt to change as the lollipop top, which theoretically makes the stem a good target for a universal vaccine.

The results from the study could be used to help public health officials to plan a more effective response to future pandemics, such as rolling out vaccines at a much earlier time and targeting specific types of vaccines at different age groups.

«CD55 also gives us a hook with which to search for new parasite proteins important for invasion, which could serve as vaccine targets.»

«If it does interfere with our immune response, it could become a target for vaccine development, not only for Zika virus, but possibly other viruses as well.

Second, we believe the vaccine may be particularly beneficial for a group of patients with the HLA - A2 type, which suggests that as we move forward, there may be advantages in targeting this population,» said John Yu, MD, vice chair of the Department of Neurosurgery, director of surgical neuro - oncology, medical director of the Brain Tumor Center and neurosurgical director of the Gamma Knife Program at Cedars - Sinai.

The vaccine was targeted especially toward the virus strain circulating in Thailand, and it may not show the same effectiveness where the virus is different, such as Africa or the U.S. And even the 31.2 percent fewer cases that it resulted in is hardly an ideal preventative strategy.

The vaccines targeted an influenza A H1N1 seasonal flu strain as well as A (H7N9), a virus considered to have the potential to trigger a human pandemic.

Flu vaccine production is always a bit of a gamble, and, unfortunately, the strain the researchers had chosen as a target wasn't the most virulent one roaming the U.S. that year.

«Vaccines should not be viewed as a silver bullet that can subdue cholera in Haiti but wider use of them, such as in campaigns targeting particularly vulnerable populations, can play a meaningful role in protecting people from illness and death.»

Gomes - Solecki's vaccine wouldn't address the spread of other tick - borne pathogens, nor target other animals such as deer or skunks that act as reservoirs for Lyme disease.

Using this approach as a template, researchers could substitute other types of antibodies and vaccines to target different tumors.

They think that the old vaccine could be useful for specific target groups, such as the elderly.

One gene produces a protein known to help the parasite infect red blood cells and is already under study as a target for a vaccine.

As such, HAP2 could provide a promising target for vaccines, therapies and other control methods.

The work should help provide targets for better drugs against S. pneumoniae, which is increasingly becoming resistant to existing therapies, as well as vaccines.

This is a very exciting discovery as it offers numerous possibilities of designing therapies and vaccines to target these exposed surfaces to treat dengue as well as other related viruses such as Zika and chikungunya.

Together, these new findings highlight NS1 as an instigator of dengue - associated vascular leak and thus pinpoint a potential target for dengue drugs and component for dengue vaccines.

Choosing the hormone as their target, chemical biologist Kim Janda of the Scripps Research Institute in San Diego, California, and colleagues at Scripps and Osaka City University in Japan, crafted three antighrelin vaccines.

The structure could inform vaccine development, as the Zika E glycoprotein is a key target of immune responses against the virus.

These technologies are particularly powerful when looking for changes in concentrations of multiple targets under specific conditions, such as following a vaccine administration, infection, or a drug treatment.

As a part of VIOLIN, we have developed Vaxign, the first web - based publically available vaccine target design tool based on bioinformatics analysis of genome sequences using the strategy of reverse vaccinology.

«The lack of vaccines and drugs for dengue has left the mosquitoes that carry the virus as one of the most promising targets for controlling the disease.

This article highlights the need to, as best we can, develop an HIV - 1 Vaccine which targets mucosa such as the GALT which are HIV - 1's main portals of entry in order to prevent latent infection from establishing in stem cells.

Treatment with AFF 1 or vehicle control was initiated in mThy1 - AS mice at age 3 mo, when early sensorimotor deficits first appear — similar to the target population for the first rollout of the human vaccine.

Meanwhile, the European Union - funded SYMPATH Project has received nearly $ 6 million from the Seventh Framework Program to test AFFiRiS» AS - targeting vaccines in patients suffering with synucleinopathies.

Since that post, there have been exciting developments in the progress of the two most advanced of these immunotherapies: PD01A, the AS - targeting active vaccine from Austrian biotechnology startup AFFiRiS AG, developed using its patented «AFFITOME» neo-antigen discovery platform of molecular mimicry; and PRX002, a humanized monoclonal Ab (mAb) under development from Prothena Corp PLC, the successor of aggregate - clearing immunotherapy pioneer Élan Pharmaceuticals.

Plus, this type of immunization, known as a conjugate vaccine, prompts the body to eliminate each of the targeted bacteria types — regardless of whether the bacteria is idle or attacking the body.

These are more specific therapies such as monoclonal antibodies and cancer vaccines, which target specific tumor antigens.

As a member of the Vaccine & Immunotherapy Center he studied accelerated vaccine development and targeted cancer therapies until FebruarVaccine & Immunotherapy Center he studied accelerated vaccine development and targeted cancer therapies until Februarvaccine development and targeted cancer therapies until February 2015.

The focus is on molecular microbiology and virology, and includes topics such as genomics, the gamut of plant and animal host - pathogen interactions, host immune responses, characterization and evolution of virulence determinants, cell cycle and differentiation, symbiosis in plant and animal associations, environmental microbiology, biodiversity and evolution, population dynamics, sex and mutagenesis, antibiotic resistance and production, drug and vaccine targets, as well as aspects of prion diseases and of fungal and protozoan biology.

Known as immunotherapeutic vaccines, they enlist a neutered version of viruses to infect healthy T cells and genetically modify them to target the disease.

The findings should help scientists to better understand the immune system, including autoimmune diseases, as well as provide potential new targets for immunotherapy and vaccine design.

«Our work sheds light on the nature of CD32 as a molecule associated with transcriptionally active HIV and proves that targeting CD32 - positive cells is unlikely to hit the HIV latent reservoir,» said Mohamed Abdel - Mohsen, Ph.D., assistant professor in The Wistar Institute Vaccine & Immunotherapy Center and first author of the study.

He is using lymphocyte receptors as targets for new therapies for lymphoma, and is currently conducting clinical trials of lymphoma vaccines.

The high expression frequency of NY - ESO - 1 indicates this as a feasible vaccine target in esophageal cancer.

Telomerase is being explored as a target for therapeutic cancer vaccines.

This type of genomic surveillance can provide crucial insights to disease control efforts, while also generating data of fundamental scientific interest, such as potential drug and vaccine targets.

With that knowledge, LJI's Klaus Ley, M.D., is working on vaccines that target inflammatory factors as a means to reduce atherosclerotic plaque formation.

22 Next, the CDC aggressively increased the dosing and expanded the target groups for the influenza vaccine, recommending a double dose for infants at both six and seven months, plus subsequent annual doses, and a dose for all pregnant women, no longer limited to the second and third trimesters.22 As of 2013, more than half of influenza vaccines were still preserved with thimerosal, 22 with the availability of non-thimerosal versions subject to supply - and - demand dynamics.

The students» work producing a manually curated whipworm genome could reveal vulnerabilities in the parasite that might be exploitable as drug or vaccine targets.

She has performed long - term studies of contraceptive vaccines for cats, with a recent focus on GnRH as the contraceptive target.