Sentences with phrase «vaccine targets»

By beginning with humans, we hoped to identify vaccine targets that will be relevant in humans.

«That's further evidence that BamE may be a new vaccine target against N. gonorrhoeae,» Sikora said.

Another possible application for the new machine is generating peptides that could be used as personalized cancer vaccines targeting unique proteins found in individual patients» tumors.

Two teams of researchers begin developing vaccines targeted against the strains of HIV prevalent in sub-Saharan Africa

Pf RH5 is a high priority vaccine target as it plays an essential and universal role in erythrocyte invasion [53, 57, 61 — 63], yet it is poorly immunogenic in vivo [61], possibly due to its late release onto the merozoite surface during erythrocyte invasion.

As a part of VIOLIN, we have developed Vaxign, the first web - based publically available vaccine target design tool based on bioinformatics analysis of genome sequences using the strategy of reverse vaccinology.

A protein displayed on the surface of malaria parasites called «TRAP» is a high - priority vaccine target, but how it interacts with human... -LSB-...]

This is why it is so difficult for humans to mount an effective immune response and why it is challenging for researchers to develop vaccines targeting the HIV envelope proteins,» Dr. Blanchard says.

«Hepatitis C mutations «outrun» immune systems, lab study shows: Study identifies mutations outside of traditional vaccine targets as barrier to vaccine development.»

We use our mammalian expression technologies to create panels of recombinant pathogen proteins that are then used to identify new subunit vaccine targets for infectious diseases.

A key program of VIOLIN is Vaxign, the first web - based publically available vaccine target design tool based on bioinformatics analysis of genome sequences using the strategy of reverse vaccinology.

As researchers learn more about genetic profile of various cancers, other work is charging ahead to deliver personalized vaccines targeted to a patient's own tumor cells

Preventative cancer vaccines target infectious agents that cause or contribute to the development of cancer.

DPX - RSV is a small, B - cell epitope peptide vaccine targeting the unmet medical needs in respiratory syncytial virus (RSV).

The epitope where 2D22 binds to the virus may therefore represent a potential vaccine target.

«We approach vaccine targets from a virus family perspective,» Young said.

However, vaccines targeting gD2 alone have not shown very robust protection in animal and human trials.

Now, the team is developing a similar vaccine targeted to HIV, which they plan to begin testing in primates within the next few months.

Current vaccines target the head, which is the part of the virus that's always changing in an effort to evade our immune defenses.

Another possibility that Irvine's lab is working on is developing treatments that could be used against tumors even when scientists don't know of a specific vaccine target for that type of tumor.

Researchers have tried to create an HIV vaccine targeting gp120, but had little success for two reasons.

Investigators first immunized the cows with DNA vaccines targeting two types of hantaviruses, Andes virus and Sin Nombre virus.

We are developing dendritic cell - based vaccines targeting telomerase, a protein expressed in over 95 percent of cancers and rarely found in normal adult cells.

BELLEROPHON aimed at developing a Staphylococcus aureus vaccine targeting cellular and humoral immune responses.

discovery of new vaccine targets by innovative approaches that allow the identification of non-classical vaccine antigens like non-protein antigens and subdominant epitopes and novel protein candidates

Tran T, De Oliveira Diniz M, Dransart E, Gey A, Merillon N, Lone YC, Godefroy S, Sibley C, Ferreira LC, Medioni J, Oudard S, Johannes * L, Tartour * E (2016) A therapeutic Her2 / neu vaccine targeting dendritic cells preferentially inhibits the growth of low Her2 / neu - expressing tumor in HLA - A2 transgenic mice.

The proteins displayed on the merozoite cell surface have long been considered attractive vaccine targets because of their direct exposure to host antibodies; however, progress in understanding the functional role of these targets has been hindered by technical challenges associated with expressing these proteins in a functionally active recombinant form.

In a recently published study, she demonstrated that a contraceptive vaccine targeting GnRH could prevent pregnancy in cats for several years after a single injection.

Available vaccines target Bordetella and other kennel cough pathogens.

The Human Papillomavirus (HPV) vaccine that prevents cervical cancer but it is actually a traditional vaccine targeting the HPV virus which causes the cancer.

«Zika may cause miscarriages, thin brain tissue in babies carried to term: Using unique mouse model, researchers believe they can develop treatment or vaccine targets in order to fight virus.»

A protein displayed on the surface of malaria parasites called «TRAP» is a high - priority vaccine target, but how it interacts with...

By examining blood plasma of two - year - olds exposed to the disease, researchers have discovered a new vaccine target: a protein recognized by the immune systems of malaria - resistant children.

H. contortus has become resistant to all major treatments against parasitic worms, so its genome is a good model to understand how drug resistance develops in this complex group of closely related parasites and will also reveal further potential drug and vaccine targets.

When comparing the two parasitic forms in an effort to discover a vaccine target, the researchers found that much of the difference arose from the expression of a peculiar genetic sequence known as a retrotransposon.

One concern is that some vaccines target naturally occurring proteins that the immune system would not normally attack.

The study size requires screening about 10,000 patients for the presence of the MAGE - A3 antigen that the vaccine targets.

«CD55 also gives us a hook with which to search for new parasite proteins important for invasion, which could serve as vaccine targets.»

The vaccines targeted an influenza A H1N1 seasonal flu strain as well as A (H7N9), a virus considered to have the potential to trigger a human pandemic.

The new vaccine targets the body's type I interferon system.

«Our new work suggests that vaccines targeting either virus could be engineered to induce both T cell and antibody responses effective to protect people in these areas.»

Both vaccines target a protein made by Zaire ebolavirus, the virus that raged through West Africa in 2014 and early 2015, killing more than 11,000 people (SN: 12/27/14, p. 14).

The finding that the V2 apex glycans are important for VRC26 bnAb development suggests that vaccines targeting this region should elicit antibodies that bind to these glycans.

«LAMP brings the vaccine target right into MHC - II molecules.»

Such efforts could reveal more about how the parasite invades red blood cells and replicates inside cells, which could generate new drug and vaccine targets.

The vaccine targets a protein produced by lactating mothers, so it could be given only to women past childbearing age.

Once in the lymph nodes, these vaccines can stimulate production of huge numbers of T cells against the vaccine target.

The resulting treatment consists of four parts: an antibody targeted to the tumor; a vaccine targeted to the tumor; IL - 2; and a molecule that blocks PD1, a receptor found on T cells.