Sentences with phrase «vaccine targets by»

discovery of new vaccine targets by innovative approaches that allow the identification of non-classical vaccine antigens like non-protein antigens and subdominant epitopes and novel protein candidates

Not exact matches

«The holy grail is to target a piece of the virus by antibody or t cell,» Tom Evans, the CEO of a company called Vaccitech that is working on a universal vaccine they hope can be used to treat all strains of influenza A, told National Geographic.

The vaccine can be targeted to the chosen pathogen by using RNA molecules which share sequence identity with the pest's genes and prevents their expression.

Vaccines work by priming the immune system to recognize the target pathogen and attack it when detected.

About half of those are infected with the most virulent strains of the virus, which are targeted by the quadrivalent vaccine given to study participants.

The epitope defined by HMAb 2D22 is a potential target for vaccines and therapeutics.

By dissecting the heritage of these cells, we can find new targets to tackle a range of conditions including infectious diseases, cancers and immune disorders, and even make vaccines more effective.»

US pig farms try to control it with vaccines, but these attempts are largely ineffective because the virus evolves too rapidly, changing the surface proteins targeted by the vaccine while keeping its internal genes unchanged.

There is no licensed vaccine available to treat or prevent dengue fever, and efforts to develop one have been complicated by the fact that dengue is caused by four distinct dengue viruses, and a vaccine must target all four serotypes (DENV 1 - 4).

This group's achievement reverses the conventional wisdom that memory B cells are induced by high - affinity cells, possibly greatly influencing vaccine strategies targeting memory B cells.

Completing the HPV vaccine series before beginning sexual activity reduces risk of infection from the HPV types targeted by the vaccine.

The result was a more diverse antibody response to the vaccination that expanded protection to include pandemic strains not targeted by the vaccine.

By examining blood plasma of two - year - olds exposed to the disease, researchers have discovered a new vaccine target: a protein recognized by the immune systems of malaria - resistant childreBy examining blood plasma of two - year - olds exposed to the disease, researchers have discovered a new vaccine target: a protein recognized by the immune systems of malaria - resistant childreby the immune systems of malaria - resistant children.

Researchers used IL - 15 to develop a whole tumor cell vaccine to target breast (TS / A) and prostate (TRAMP - C2) cancer cells in animal models; results showed that tumor cells stopped growing after the vaccine was introduced and that beneficial effects were enhanced further when IL - 15Rα was co-produced by the vaccine cells.

By defining the threshold of the amount of virus needed for transmission, the research also provides a target that experimental dengue vaccines and drugs must prevent the virus from reaching in order to be successful at preventing the spread of disease during natural infection.

Findings from this study could help make flu immunization programs more effective; by better targeting vaccines or by eventually eliminating one of the flu lineages completely.

Both vaccines target a protein made by Zaire ebolavirus, the virus that raged through West Africa in 2014 and early 2015, killing more than 11,000 people (SN: 12/27/14, p. 14).

The albumin - targeted vaccines provoked immune responses five to 10 times stronger than those generated by the peptide antigens alone.

Two types of vaccines were used for the study: one constructed with genetically engineered DNA molecules that teach immune system cells to recognize premalignant cells expressing HPV16 E7 proteins, and one that is a non-infectious, engineered virus that targets and kills precancerous cells marked by HPV16 and HPV18 E6 and E7 proteins.

The vaccine targets a protein produced by lactating mothers, so it could be given only to women past childbearing age.

A second HPV vaccine, Cervarix, which is made by GSK and targets some different HPV strains, is still in review by the FDA.

But by eliminating the sugar molecule, the new mutation also affects «a key region in the virus that is targeted by the immune system,» Hensley adds, making the vaccine less effective.

By identifying novel biological pathways and publishing details of these interactions, the study team aims to help uncover useful targets in developing better vaccines and cancer treatments.

«This helps us understand that process, and it opens up the window to targeting these cells by designing vaccines that prevent autoimmunity.»

A study led by St. Jude Children's Research Hospital identifies new path to a universal influenza vaccine emphasizing production of broadly specific antibodies that target multiple flu viruses

«This will allow us to design better inhibitors or vaccines that block invasion by targeting multiple steps at the same time.»

«In addition, our method offers the potential to accelerate the development of new vaccines by allowing the efficient evaluation of candidate target antigens.»

To meet this end, CCIR members take advantage of resources offered by MD Anderson, including the CCSG Shared Resources, Immune Monitoring Core Laboratory and GMP Cell Facility, allowing them to follow the «bench - to - beside» approach to develop and improve cancer immunotherapy in the form of cellular therapy, a vaccine or targeting antibody, either alone or in combination with conventional therapies or newly developed therapies.

Being both tumor - specific and widely expressed in human tumors, MAGE - A3 is an ideal cancer vaccine target and will be the focus of many clinical trials, including the largest clinical trial ever conducted in lung cancer, MAGRIT, launched by GlaxoSmithKline in 2007.

By beginning with humans, we hoped to identify vaccine targets that will be relevant in humans.

By understanding erythrocyte invasion in depth, his group aims to identify molecular steps in the invasion process that could be targeted by new drugs or vaccineBy understanding erythrocyte invasion in depth, his group aims to identify molecular steps in the invasion process that could be targeted by new drugs or vaccineby new drugs or vaccines.

More importantly, Gack found that avian, swine, and human flu viruses block TRIM25 to evade immune defense by RIG - I, unraveling a molecular target for the design of antiviral drugs and vaccines.

Now, a new vaccine under development could deal another blow to the disease, lowering the number of deaths even further by targeting dozens of additional strains of S. pneumoniae, and anticipating future versions of the bacteria responsible for pneumococcal disease, which includes sepsis and meningitis.

The differences occurred only in the sequences for the proteins targeted by the HIV vaccine.

Rationalise drug and vaccine development by providing a systematic catalogue of genetic variation in potential drug or vaccine targets, crucial information for assessing the viability and sustainability of a proposed drug or vaccine.

Studies conducted and supported by NIAID have led to important new discoveries about the microbes that cause NTDs, the identification of targets for potential new drugs and vaccines, and the development of strategies for controlling organisms that transmit NTD - causing agents to humans.

In the new study, the team's experimental vaccine works by effectively misdirecting the immune system to fight off a more dangerous target than the allergen.

Farokhzad and colleagues have considerable expertise with bench - to - bedside translation of nanotechnologies for medical applications, and foundational work done in part by his team has led to the development and first in human testing of a targeted nanoparticle capable of controlling drug release for treatment of cancers, and the first in human testing of a targeted nanoparticle vaccine capable of orchestrating an immune response to facilitate smoking cessation and relapse prevention.

Serogrouping identified isolates expressing capsule antigens targeted by the vaccine.

The proteins displayed on the merozoite cell surface have long been considered attractive vaccine targets because of their direct exposure to host antibodies; however, progress in understanding the functional role of these targets has been hindered by technical challenges associated with expressing these proteins in a functionally active recombinant form.

By contrast, NK cell profiles of individuals receiving an HIV vaccine indicated NK cell engagement through direct cell recognition of target cells.

Broadly neutralizing antibodies (bNAbs), if elicited by a vaccine, could prevent infection by a broad range of HIV's many variants, and the Envelope protein is the sole target available to these antibodies.

Ken SHORTMAN, WEHI, Melbourne, AUS «Enhancing protective antibody responses by targeting vaccine antigens to Clec9A on dendritic cells» Host:...

Although no one knows for sure at exactly what age this happens, research shows that by 16 weeks combination shots are extremely effective at producing an adequate immune response to the diseases targeted by the AAHA's core vaccines.

The program targets clients whose pets» vaccines have lapsed... and by «lapsed» they mean that the last vaccination was given 18 months ago or more!

Animal Friends» Clinic Services Program consists of three core components each uniquely designed to support a targeted population by offering pets high - quality, low - cost spay / neuter, vaccines and wellness services.

VANGUARD ® crLyme is a multivalent vaccine which contains an OspA protein and a single OspC protein that is composed of antigenic material from seven common types of OspC found in Lyme - infected dogs in the U.S. 1 Its uniquely targeted design helps provide a broad spectrum of coverage while delivering a low - reactive vaccine by minimizing the amount of extraneous proteins administered to the dog.

About Vanguard crLyme Vanguard crLyme is a next - generation multivalent vaccine which contains outer surface protein A (OspA) protein and a single OspC protein that is composed of antigenic material from seven common types of OspC found in Lyme - infected dogs in the U.S. 1 Its uniquely targeted design helps provide a broad spectrum of coverage while delivering a low - reactive vaccine by minimizing the amount of extraneous proteins administered to the dog.

I also urge you to listen to this short, succinct and compelling talk in which Pandya illustrates the merits of getting the right scientific expertise to the right problem by showing how targeted meteorological forecasting helped improve the deployment of limited supplies of meningitis vaccine in sub-Saharan Africa, saving lives and money: