Sentences with phrase «vaccine targets for»

We use our mammalian expression technologies to create panels of recombinant pathogen proteins that are then used to identify new subunit vaccine targets for infectious diseases.

Another possibility that Irvine's lab is working on is developing treatments that could be used against tumors even when scientists don't know of a specific vaccine target for that type of tumor.

Not exact matches

His work indicates that this cell surface marker could serve as a target for a novel brain cancer vaccine or T - cell therapies engineered to recognize and kill tumors carrying that neoantigen.

Beyond the payroll tax and charitable donation programs, Cuomo offered up ideas to reduce traffic congestion in New York City, expand availability of flu vaccines for children, impose restrictions on sex offenders, provide funding for an early voting program, ban synthetic marijuana sales and target physicians who engage in medical misconduct.

Fiers discovered a key protein on the influenza virus that could serve as a target for a universal vaccine; the drug has shown promise in an early clinical trial.

The epitope defined by HMAb 2D22 is a potential target for vaccines and therapeutics.

Another possible application for the new machine is generating peptides that could be used as personalized cancer vaccines targeting unique proteins found in individual patients» tumors.

If these test - tube results are confirmed in infected animals and people, the viral proteins could be targets for anti-Ebola vaccines as well as for drugs that treat Ebola infections.

CCR5 should remain «a very important target for vaccines and drugs,» he says, noting that they have found only one person with the double CCR5 defect in 300 people studied so far.

«In addition, this platform can be used to develop safe vaccine candidates for other flaviviruses such as Zika virus, where pregnant women are the target group for vaccination.»

Babayan says potential vaccines should be tested for whether their targets adapt to them in this way.

In addition, vaccine - makers that use eggs can not begin developing new vaccines that target new virus strains until the U.S. Centers for Disease Control and Prevention (CDC) creates a live - virus reference strain for these companies to work with, a process that could take several weeks.

The study size requires screening about 10,000 patients for the presence of the MAGE - A3 antigen that the vaccine targets.

(Neuraminidase, the bigger player in disease after infection, is a target for influenza treatments but not a major focus for vaccine development.)

The findings underscore the need for targeted research to further evaluate manufacturing strategies and vaccine antigens and platforms, according to the authors.

Scientists had known that the hemagglutinin stem, or stalk, isn't as apt to change as the lollipop top, which theoretically makes the stem a good target for a universal vaccine.

The genetic code also holds clues to Chlamydia's surface proteins, which Stephens says should give researchers new targets for vaccines, diagnostic tests, and drugs.

«CD55 also gives us a hook with which to search for new parasite proteins important for invasion, which could serve as vaccine targets.»

«If it does interfere with our immune response, it could become a target for vaccine development, not only for Zika virus, but possibly other viruses as well.

Bach2, an important gene for inducing memory B cells, may become an important target in vaccine strategies.

«The microgravity environment of the International Space Station is now being used for myriad lines of research, for example: vaccine development, finding novel molecular targets against drug - resistant pathogens, and testing of molecules to be used against osteoporosis or cancer,» Zea says.

Second, we believe the vaccine may be particularly beneficial for a group of patients with the HLA - A2 type, which suggests that as we move forward, there may be advantages in targeting this population,» said John Yu, MD, vice chair of the Department of Neurosurgery, director of surgical neuro - oncology, medical director of the Brain Tumor Center and neurosurgical director of the Gamma Knife Program at Cedars - Sinai.

Therefore, the most logical approach for protecting threatened carnivores from canine distemper virus may be to target the vaccine on the endangered species itself.»

The authors say: «The most important public health implication of our analysis was that decreases in overall IPD rates in children — the group targeted for PCV7 vaccination — occurred quickly and were sustained after vaccine introduction despite increases in [non-vaccine serotype] rates.»

In this paper, Kumaraswami said he and his team found a critical target on which to focus for developing a potential Group A Streptococcus vaccine or antibiotic to fight it.

Now that we have discovered how Group A strep bacteria communicate with each other to coordinate the production of this toxin, we can target the signaling pathway for vaccine and antimicrobial development.»

By defining the threshold of the amount of virus needed for transmission, the research also provides a target that experimental dengue vaccines and drugs must prevent the virus from reaching in order to be successful at preventing the spread of disease during natural infection.

Cincinnati Cancer Center (CCC) and UC Cancer Institute researchers have found that a vaccine, targeting tumors that produce a certain protein and receptor responsible for communication between cells and the body's immune system, could initiate the immune response to fight cancer.

To develop subunit vaccines for other diseases, scientists have tried targeting them to lymph nodes using nanoparticles to deliver them, or tagging them with antibodies specific to immune cells in the lymph nodes.

Which groups should be targeted for the vaccine, and who should be first in line if the supply falls short, will be discussed on 29 July at a special meeting of the Advisory Committee for Immunization Practices in Atlanta.

«This younger population should be targeted for the use of the quadrivalent influenza vaccines.»

It also has a key role to play for the future of radiation vaccine research — called RadVax for short — in which doctors are trying to understand why targeted doses of radiation can boost the body's entire immune system in select cases.

About 50 code for proteins that appear on the surfaces of these microbial pests and could be drug targets or vaccine candidates.

A vaccine that targets qualities of the virus responsible for replicative capacity could have an important impact on disease progression and secondary transmission.»

«New clues to how a successful HIV vaccine could work: Sugar molecules on HIV envelope protein are likely target for future candidate vaccines.»

The finding that the V2 apex glycans are important for VRC26 bnAb development suggests that vaccines targeting this region should elicit antibodies that bind to these glycans.

Two types of vaccines were used for the study: one constructed with genetically engineered DNA molecules that teach immune system cells to recognize premalignant cells expressing HPV16 E7 proteins, and one that is a non-infectious, engineered virus that targets and kills precancerous cells marked by HPV16 and HPV18 E6 and E7 proteins.

Therefore, this could provide an important target for disease interventions or vaccine designs.

Gomes - Solecki's vaccine wouldn't address the spread of other tick - borne pathogens, nor target other animals such as deer or skunks that act as reservoirs for Lyme disease.

Scientists are also breaking ground with nucleic acid platforms that have the potential to deliver cancer vaccines, for neoantigens and other targets.

The ability to design new protein nanostructures could have useful implications in targeted delivery of drugs, in vaccine development and in plasmonics — manipulating electromagnetic signals to guide light diffraction for information technologies, energy production or other uses.

Safety considerations are especially critical, given that the target population for a Zika vaccine would likely include men and women of childbearing age.

Vaccine manufacturers have notified officials that they can't make good on their targets, Anne Schuchat, director of CDC's National Center for Immunization and Respiratory Diseases, said during a press conference today.

It would be most inappropriate if the vaccine stayed unused in a warehouse somewhere or if it were used for ridiculous targets.

This is why it is so difficult for humans to mount an effective immune response and why it is challenging for researchers to develop vaccines targeting the HIV envelope proteins,» Dr. Blanchard says.

The dilemma for vaccine research is that these cells are also the target cells for an infection with HIV or SIV.

«Despite substantial public health efforts, flu vaccine rates for U.S. children are well below national targets,» says lead author Sarah J. Clark, M.P.H., associate director of the University of Michigan C.S. Mott Children's Hospital National Poll on Children's Health and associate research scientist in the U-M Department of Pediatrics.

They think that the old vaccine could be useful for specific target groups, such as the elderly.

One gene produces a protein known to help the parasite infect red blood cells and is already under study as a target for a vaccine.

Because different proteins are produced in each stage of the microbe's cycle, Plasmodium presents a shifting target for potential vaccines.