Sentences with phrase «vaccine targets in»

«Zika may cause miscarriages, thin brain tissue in babies carried to term: Using unique mouse model, researchers believe they can develop treatment or vaccine targets in order to fight virus.»

The high expression frequency of NY - ESO - 1 indicates this as a feasible vaccine target in esophageal cancer.

Not exact matches

The vaccine in turn will attack targets that arise from genetic mutations in the patient's tumor.

DPX - RSV is a small, B - cell epitope peptide vaccine targeting the unmet medical needs in respiratory syncytial virus (RSV).

«Every government initiative, including the HPV [Human papillomavirus] vaccine, will increase [teenage infertility], but as all the targets revolve around pregnancy, no - one in power knows how many young people they are making sterile and nobody cares», it read.

Mr. Speaker, sector challenges affected the purchase of vaccines, resulting in lower than targeted immunization coverage in the first half of 2017.

Beyond the payroll tax and charitable donation programs, Cuomo offered up ideas to reduce traffic congestion in New York City, expand availability of flu vaccines for children, impose restrictions on sex offenders, provide funding for an early voting program, ban synthetic marijuana sales and target physicians who engage in medical misconduct.

To generate a rich source of potential vaccine and drug target candidates, the team identified a set of genes that are more active in certain stages of the parasite life cycle and within the parasite's gut.

H. contortus has become resistant to all major treatments against parasitic worms, so its genome is a good model to understand how drug resistance develops in this complex group of closely related parasites and will also reveal further potential drug and vaccine targets.

About 85 % of the target population was vaccinated, estimates Seth Berkley, who heads GAVI, the Vaccine Alliance in Geneva — enough to temper outbreaks but not prevent them.

Fiers discovered a key protein on the influenza virus that could serve as a target for a universal vaccine; the drug has shown promise in an early clinical trial.

Another possible application for the new machine is generating peptides that could be used as personalized cancer vaccines targeting unique proteins found in individual patients» tumors.

Recombinant vaccines rely on one or more antigens — proteins associated with the target bacterium — that boost an immune response; in this case Mycobacterium tuberculosis, which causes TB.

If these test - tube results are confirmed in infected animals and people, the viral proteins could be targets for anti-Ebola vaccines as well as for drugs that treat Ebola infections.

CCR5 should remain «a very important target for vaccines and drugs,» he says, noting that they have found only one person with the double CCR5 defect in 300 people studied so far.

There he worked on anticancer vaccines, identifying drug targets, preparing vaccine formulations, and testing cellular responses in vaccinated patients.

The company's initial vaccine formulation targets Rift Valley Fever, found in Africa and the Arabian Peninsula.

The protein is genetically identical in all strains of S. aureus, so a vaccine that targets GMD could potentially be universal.

«In addition, this platform can be used to develop safe vaccine candidates for other flaviviruses such as Zika virus, where pregnant women are the target group for vaccination.»

Babayan says potential vaccines should be tested for whether their targets adapt to them in this way.

Italy's National Institute of Health in Rome recently completed a phase II clinical trial of an experimental vaccine that targets the Tat protein.

In addition, vaccine - makers that use eggs can not begin developing new vaccines that target new virus strains until the U.S. Centers for Disease Control and Prevention (CDC) creates a live - virus reference strain for these companies to work with, a process that could take several weeks.

(Neuraminidase, the bigger player in disease after infection, is a target for influenza treatments but not a major focus for vaccine development.)

In 2016, cryo - EM was used to map the structure of the Zika virus (SN: 4/30/16, p. 10), helping to identify possible regions to target with a vaccine or antiviral compounds.

However, vaccines targeting gD2 alone have not shown very robust protection in animal and human trials.

CTL119 manufacturing begins with a patient's own T cells, some of which are removed and then reprogrammed in Penn's Clinical Cell and Vaccine Production Facility with a gene transfer technique designed to teach the T cells to target and kill tumor cells.

Bach2, an important gene for inducing memory B cells, may become an important target in vaccine strategies.

Researchers at MedImmune, a Maryland - based biotech company, and at Washington University in St. Louis whipped up two separate vaccine formulations in the hope that at least one would successfully target an «adhesion» molecule called Filamentous H, or FimH, present on E. coli.

In Europe, which has yet to see sustained transmission in communities, four countries cut deals with GlaxoSmithKline to purchase more than 100 million doses of a vaccine that targets the new H1N1 viruIn Europe, which has yet to see sustained transmission in communities, four countries cut deals with GlaxoSmithKline to purchase more than 100 million doses of a vaccine that targets the new H1N1 viruin communities, four countries cut deals with GlaxoSmithKline to purchase more than 100 million doses of a vaccine that targets the new H1N1 virus.

Second, we believe the vaccine may be particularly beneficial for a group of patients with the HLA - A2 type, which suggests that as we move forward, there may be advantages in targeting this population,» said John Yu, MD, vice chair of the Department of Neurosurgery, director of surgical neuro - oncology, medical director of the Brain Tumor Center and neurosurgical director of the Gamma Knife Program at Cedars - Sinai.

Now, the team is developing a similar vaccine targeted to HIV, which they plan to begin testing in primates within the next few months.

The vaccine was targeted especially toward the virus strain circulating in Thailand, and it may not show the same effectiveness where the virus is different, such as Africa or the U.S. And even the 31.2 percent fewer cases that it resulted in is hardly an ideal preventative strategy.

Researchers used IL - 15 to develop a whole tumor cell vaccine to target breast (TS / A) and prostate (TRAMP - C2) cancer cells in animal models; results showed that tumor cells stopped growing after the vaccine was introduced and that beneficial effects were enhanced further when IL - 15Rα was co-produced by the vaccine cells.

Other vaccines in trials target the blood - cell stage, and contain a parasite protein called AMA - 1, meant to prime the body's immune system to attack it.

The authors say: «The most important public health implication of our analysis was that decreases in overall IPD rates in children — the group targeted for PCV7 vaccination — occurred quickly and were sustained after vaccine introduction despite increases in [non-vaccine serotype] rates.»

In this paper, Kumaraswami said he and his team found a critical target on which to focus for developing a potential Group A Streptococcus vaccine or antibiotic to fight it.

«Vaccines should not be viewed as a silver bullet that can subdue cholera in Haiti but wider use of them, such as in campaigns targeting particularly vulnerable populations, can play a meaningful role in protecting people from illness and death.»

«Our new work suggests that vaccines targeting either virus could be engineered to induce both T cell and antibody responses effective to protect people in these areas.»

In addition to targeting infectious diseases, the researchers are using this approach to create cancer vaccines that would teach the immune system to recognize and destroy tumors.

By defining the threshold of the amount of virus needed for transmission, the research also provides a target that experimental dengue vaccines and drugs must prevent the virus from reaching in order to be successful at preventing the spread of disease during natural infection.

Current vaccines target the head, which is the part of the virus that's always changing in an effort to evade our immune defenses.

To develop subunit vaccines for other diseases, scientists have tried targeting them to lymph nodes using nanoparticles to deliver them, or tagging them with antibodies specific to immune cells in the lymph nodes.

Which groups should be targeted for the vaccine, and who should be first in line if the supply falls short, will be discussed on 29 July at a special meeting of the Advisory Committee for Immunization Practices in Atlanta.

They created a few different vaccines, targeting HIV, melanoma, and cervical cancer, and tested them in mice.

Both vaccines target a protein made by Zaire ebolavirus, the virus that raged through West Africa in 2014 and early 2015, killing more than 11,000 people (SN: 12/27/14, p. 14).

This is no easy task, and a study out in the journal Scientific Reports suggests that one of the most promising strategies — creating a vaccine that targets the «stalk» of a protein that covers the flu virus — is a strong one, but isn't completely bulletproof.

It also has a key role to play for the future of radiation vaccine research — called RadVax for short — in which doctors are trying to understand why targeted doses of radiation can boost the body's entire immune system in select cases.

Future candidate vaccines are therefore likely to include this glycan cluster among their specific viral targets in order to maximize the chances of stimulating an effective antibody response.

The vaccine triggers an immune response that targets ghrelin, a hormone naturally made in the gut and transported to the brain; ghrelin spikes with hunger and is thought to stimulate the storage of body fat.

Identifying those two molecular targets could help in the design of better vaccine strategies and tumor immunotherapies.»