Sentences with phrase «vaccines targeting gd2»

We are developing dendritic cell - based vaccines targeting telomerase, a protein expressed in over 95 percent of cancers and rarely found in normal adult cells.

Investigators first immunized the cows with DNA vaccines targeting two types of hantaviruses, Andes virus and Sin Nombre virus.

This is why it is so difficult for humans to mount an effective immune response and why it is challenging for researchers to develop vaccines targeting the HIV envelope proteins,» Dr. Blanchard says.

The finding that the V2 apex glycans are important for VRC26 bnAb development suggests that vaccines targeting this region should elicit antibodies that bind to these glycans.

«Our new work suggests that vaccines targeting either virus could be engineered to induce both T cell and antibody responses effective to protect people in these areas.»

However, vaccines targeting gD2 alone have not shown very robust protection in animal and human trials.

Another possible application for the new machine is generating peptides that could be used as personalized cancer vaccines targeting unique proteins found in individual patients» tumors.

DPX - RSV is a small, B - cell epitope peptide vaccine targeting the unmet medical needs in respiratory syncytial virus (RSV).

H. contortus has become resistant to all major treatments against parasitic worms, so its genome is a good model to understand how drug resistance develops in this complex group of closely related parasites and will also reveal further potential drug and vaccine targets.

As researchers learn more about genetic profile of various cancers, other work is charging ahead to deliver personalized vaccines targeted to a patient's own tumor cells

The epitope where 2D22 binds to the virus may therefore represent a potential vaccine target.

«We approach vaccine targets from a virus family perspective,» Young said.

The study size requires screening about 10,000 patients for the presence of the MAGE - A3 antigen that the vaccine targets.

«That's further evidence that BamE may be a new vaccine target against N. gonorrhoeae,» Sikora said.

«CD55 also gives us a hook with which to search for new parasite proteins important for invasion, which could serve as vaccine targets.»

By examining blood plasma of two - year - olds exposed to the disease, researchers have discovered a new vaccine target: a protein recognized by the immune systems of malaria - resistant children.

Now, the team is developing a similar vaccine targeted to HIV, which they plan to begin testing in primates within the next few months.

The vaccines targeted an influenza A H1N1 seasonal flu strain as well as A (H7N9), a virus considered to have the potential to trigger a human pandemic.

The new vaccine targets the body's type I interferon system.

Current vaccines target the head, which is the part of the virus that's always changing in an effort to evade our immune defenses.

Both vaccines target a protein made by Zaire ebolavirus, the virus that raged through West Africa in 2014 and early 2015, killing more than 11,000 people (SN: 12/27/14, p. 14).

Such efforts could reveal more about how the parasite invades red blood cells and replicates inside cells, which could generate new drug and vaccine targets.

«LAMP brings the vaccine target right into MHC - II molecules.»

The vaccine targets a protein produced by lactating mothers, so it could be given only to women past childbearing age.

«Hepatitis C mutations «outrun» immune systems, lab study shows: Study identifies mutations outside of traditional vaccine targets as barrier to vaccine development.»

Another possibility that Irvine's lab is working on is developing treatments that could be used against tumors even when scientists don't know of a specific vaccine target for that type of tumor.

Once in the lymph nodes, these vaccines can stimulate production of huge numbers of T cells against the vaccine target.

The resulting treatment consists of four parts: an antibody targeted to the tumor; a vaccine targeted to the tumor; IL - 2; and a molecule that blocks PD1, a receptor found on T cells.

Researchers have tried to create an HIV vaccine targeting gp120, but had little success for two reasons.

«Zika may cause miscarriages, thin brain tissue in babies carried to term: Using unique mouse model, researchers believe they can develop treatment or vaccine targets in order to fight virus.»

The vaccine targeted a flu strain that didn't look like most of the strains traveling around the Northern Hemisphere during the 2014 - 2015 flu season, researchers report June 25 in Cell Reports.

Being both tumor - specific and widely expressed in human tumors, MAGE - A3 is an ideal cancer vaccine target and will be the focus of many clinical trials, including the largest clinical trial ever conducted in lung cancer, MAGRIT, launched by GlaxoSmithKline in 2007.

Nicola was recognized for his longstanding research efforts to understand how herpesviruses cause infections in humans and animals and to identify novel drug and vaccine targets.

We use our mammalian expression technologies to create panels of recombinant pathogen proteins that are then used to identify new subunit vaccine targets for infectious diseases.

This step is essential for parasite transmission to humans and understanding the underlying mechanisms can help to identify new drug - and vaccine targets.

By beginning with humans, we hoped to identify vaccine targets that will be relevant in humans.

As a part of VIOLIN, we have developed Vaxign, the first web - based publically available vaccine target design tool based on bioinformatics analysis of genome sequences using the strategy of reverse vaccinology.

A key program of VIOLIN is Vaxign, the first web - based publically available vaccine target design tool based on bioinformatics analysis of genome sequences using the strategy of reverse vaccinology.

A protein displayed on the surface of malaria parasites called «TRAP» is a high - priority vaccine target, but how it interacts with human... -LSB-...]

BELLEROPHON aimed at developing a Staphylococcus aureus vaccine targeting cellular and humoral immune responses.

A protein displayed on the surface of malaria parasites called «TRAP» is a high - priority vaccine target, but how it interacts with...

The focus is on molecular microbiology and virology, and includes topics such as genomics, the gamut of plant and animal host - pathogen interactions, host immune responses, characterization and evolution of virulence determinants, cell cycle and differentiation, symbiosis in plant and animal associations, environmental microbiology, biodiversity and evolution, population dynamics, sex and mutagenesis, antibiotic resistance and production, drug and vaccine targets, as well as aspects of prion diseases and of fungal and protozoan biology.

discovery of new vaccine targets by innovative approaches that allow the identification of non-classical vaccine antigens like non-protein antigens and subdominant epitopes and novel protein candidates

Rationalise drug and vaccine development by providing a systematic catalogue of genetic variation in potential drug or vaccine targets, crucial information for assessing the viability and sustainability of a proposed drug or vaccine.

The high expression frequency of NY - ESO - 1 indicates this as a feasible vaccine target in esophageal cancer.

Tran T, De Oliveira Diniz M, Dransart E, Gey A, Merillon N, Lone YC, Godefroy S, Sibley C, Ferreira LC, Medioni J, Oudard S, Johannes * L, Tartour * E (2016) A therapeutic Her2 / neu vaccine targeting dendritic cells preferentially inhibits the growth of low Her2 / neu - expressing tumor in HLA - A2 transgenic mice.

The proteins displayed on the merozoite cell surface have long been considered attractive vaccine targets because of their direct exposure to host antibodies; however, progress in understanding the functional role of these targets has been hindered by technical challenges associated with expressing these proteins in a functionally active recombinant form.

This type of genomic surveillance can provide crucial insights to disease control efforts, while also generating data of fundamental scientific interest, such as potential drug and vaccine targets.

Pf RH5 is a high priority vaccine target as it plays an essential and universal role in erythrocyte invasion [53, 57, 61 — 63], yet it is poorly immunogenic in vivo [61], possibly due to its late release onto the merozoite surface during erythrocyte invasion.

«A vaccine targeting this protein would potentially protect the individuals at highest risk for severe disease,» study senior author Dr. James Fleckenstein, an associate professor of medicine and molecular microbiology at Washington University School of Medicine in St. Louis, said in a statement.