Sentences with word «vaccinia»

Late last week, FDA worked with the United States Attorney to ask a court to seize the components of a product that involved the use of vaccinia virus vaccine as part of a purported treatment for cancer that FDA believes created the potential for substantial risks to patients.

They have taken extensive precautions to prevent the spread of vaccinia to health care workers and other patients from the moment he arrived.

Here we show that a modified vaccinia virus Ankara (MVA) vaccine expressing the MERS - CoV spike protein confers mucosal immunity in dromedary camels.

While at UConn, he researched improvements to the system for generating recombinant vaccinia viruses in the laboratory of Dr. Paulo Verardi.

«The novelty here, with vaccinia, is that it's not just preventing the virus superinfecting, but physically it's repelling the virus away,» says Smith, whose team reports its findings today in Science.

Thanks to its resemblance to the smallpox virus, researchers were able to use vaccinia as a vaccine for the disease, eventually leading to its eradication in the late 1970s.

Prime - boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum infection in Kenyan adult.

Elucidating the essential role of the A14 phosphoprotein in vaccinia virus morphogenesis: construction and characterization of a Tetracycline - inducible recombinant.

The standard smallpox vaccine, a virus called vaccinia, is amazingly effective, which explains how the disease was eradicated in the late 1970s.

Bavarian Nordic, a German - Danish company, produces a weakened vaccinia strain called Modified Vaccinia Ankara (MVA) that doesn't replicate in humans.

MVA is an alternative to the classic vaccinia virus, which can cause serious side effects.

Similarly, the entry for vaccinia, and even an essay on virology (one of 124 «windows» reviews by luminaries in their fields), mention smallpox without saying that it has been eradicated — one of the greatest achievements of medical science.

When other vaccinia viruses come knocking, long projections of another protein, actin, shoot out from the cell membrane, causing the virus to bounce off.

Pexa - Vec is an engineered virus based on the harmless vaccinia cowpox virus — also the basis for the original smallpox vaccine.

In a conversation about one of Evan's earlier vaccinia papers, Lederman told Evans that he'd love to know whether horsepox still works as a vaccine, but that he had had trouble getting hold of the virus.

PANVAC - V, which uses the same virus as the smallpox vaccine, is a live but weakened vaccinia vaccine (meaning the virus can still multiply) that is given in the arm.

While looking carefully at the areas of cell destruction induced by the viruses — called plaques — he and colleagues noticed that vaccinia spread four times faster than its replication cycle would allow.

However, smallpox and yellow fever vaccines increase the risk of infants developing vaccinia and encephalitis.

Lederman, who says he's «obsessed» with Jenner and has been working on a biography of the scientist for 20 years, is convinced that Jenner's original vaccine, now named vaccinia, was derived from a virus circulating in horses, not cows, as folklore has it.

This image shows vaccinia viruses (the green dots) erupting from the surface of a human cell on long red actin plumes.

Most Americans older than 40 received vaccinia as children in smallpox vaccines, but the company found no evidence that having had this vaccination hindered the effectiveness of the new virus.

He wonders whether it's not vaccinia, the virus used to induce smallpox resistance, but some other component of the vaccine that's prompting inflammation, perhaps bovine cells from the manufacturing process.

In vivo, primary and secondary cytotoxic T cell responses against vaccinia and lymphocytic choriomeningitis virus were within normal ranges.

But the frontrunner is MVA, produced in the 1960s by German scientist Anton Mayr by growing vaccinia in chicken embryo fibroblasts for 570 generations.

In a separate study published online this week by the Proceedings of the National Academy of Sciences, they show, among other things, that classic vaccinia causes weight loss, skin lesions, and death in severely immunocompromised mice, while MVA does not — even if the dose was 1000 times higher than normal.

Meanwhile, phase 1 trials are to begin early next year for a two - vaccine regimen involving an adenovirus - based vaccine developed by US pharmaceutical company Johnson & Johnson and the NIAID, and a vaccine that is made from vaccinia (a virus similar to the one that causes cowpox) developed by Bavarian Nordic in Denmark.

Searching for alternatives, Jay Hooper and his colleagues at the U.S. Army Medical Research Institute of Infectious Diseases in Fort Detrick, Maryland, developed a vaccine composed of the genes for four vaccinia proteins thought to be important in eliciting immunity.

Two other monkeys who were given vaccinia did better, as expected, developing no disease at all.

Long used as a vaccine for smallpox, vaccinia patiently waits up to 72 hours before busting out.

Since then, scientists have continued to study vaccinia as a platform to develop vaccines against other diseases.

They discovered that vaccinia produces two proteins right after it infects a cell.

In other immune cells, vaccinia goes pop in as little as 4 hours.

Using a light microscope, researchers at the Swiss Federal Institute of Technology in Zürich watched fluorescently tagged vaccinia virus — a more benign cousin of smallpox virus — migrate toward target cells.

Tonix has already shown that horsepox can protect mice from an otherwise lethal dose of vaccinia, he says, and is investing in production of the virus under the strict conditions that would allow human trials.

MHRP scientists, working with NIAID, have developed an attenuated viral vector — modified vaccinia Ankara — vaccine candidate, MVA - CMDR (HIV - 1 CM235 env / CM240 gag - pol).

[3] Odunsi K, Matsuzaki J, Karbach J, Neumann A, Mhawech - Fauceglia P, Miller A, Beck A, Morrison CD, Ritter G, Godoy H, Lele S, duPont N, Edwards R, Shrikant P, Old LJ, Gnjatic S, Jäger E. Efficacy of vaccination with recombinant vaccinia and fowlpox vectors expressing NY - ESO - 1 antigen in ovarian cancer and melanoma patients.

The proteins work together to form a complex on the cell's surface that prevents other vaccinia virus particles from entering (a process called superinfection).

The Pexa - Vec virus was originally developed by Michael Mastrangelo, MD, and Edmund Lattime, PhD, of Thomas Jefferson University in Philadelphia, who engineered the harmless vaccinia virus to infect only cancer cells and other rapidly dividing cells, as well as to stimulate immune activity, in hopes of boosting the immune response to tumors.

However, the classic smallpox vaccine, a weakened poxvirus called vaccinia, can cause serious side effects and even death in people with compromised immune systems, eczema, or atopic dermatitis.

Protein chemist Michael Way, cell biologist Sally Cudmore, and their colleagues at the European Molecular Biology Laboratory in Heidelberg and at the Pasteur Institute in Paris have found that vaccinia — a virus used in smallpox vaccines — surfs through cells on piles of actin, one of the basic structural proteins in the cellular skeleton.

The vaccinia virus has been developed by the biotechnology company Jennerex — named after Edward Jenner, who in the 18th century discovered that a cowpox virus could inoculate against smallpox.

Replication of vaccinia is the first step to killing cancer cells and shrinking tumors with this approach.

For their studies, Greber and his team with PhD students I - Hsuan Wang, Vardan Andriasyan and senior research scientist Dr. Maarit Suomalainen used cell cultures and human adenoviruses causing respiratory disease and conjunctivitis, herpes viruses and vaccinia virus, the latter in collaboration with Dr. Jason Mercer and his PhD student Samuel Kilcher from the ETH Zurich.

Today vaccines (vaccinia is Latin for «cowpox») of all forms save 3 million lives per year worldwide, and at a bargain price.

Geoffrey Smith and his team of virologists at Imperial College London were curious about the vaccinia virus, and set up a video microscope to watch how the virus spreads through cells.

When Smith watched the vaccinia virus infecting monkey liver cells, he thought that it was spreading far too quickly.

Both assays (for translation enhancement and internal ribosomal initiation) were validated under cell - free conditions and in human cells, using a vaccinia virus vector.