Sentences with phrase «vaccinology approach»

In the battle against multidrug resistance, the ideal way of preventing disease is a vaccine, and having a structure of BamE opens the door to a structural vaccinology approach.»

Not exact matches

Kim et al. suggest that moving away from empirical research to either systems analysis or hypothesis driven approaches may advance our vaccinology understanding.5 Interrogation of peripheral blood responses following vaccination, termed «systems vaccinology», has led to the identification of immune signatures and pathways that are correlated to immune responses.

Hypothesis driven approaches to vaccinology can utilise the knowledge gained from mechanistic mouse models and our molecular understanding of intrinsic defects to human cells.5 However, caution is required when extrapolating data from murine models, as there are substantial differences between immune ageing in mice and humans.6 Nevertheless, model systems and ex vivo analyses of molecular alterations in aged human cells have identified multiple changes in the vaccination response with age and the aged immune system in general.