The overall goal of this study is to improve knowledge of the mechanism of HPV carcinogenesis and discover potential biomarkers in the vaginal microbiome predictive or protective of persistent HPV infection through interrogation of
vaginal microbiota in a well phenotyped, homogenous cohort of Asian women.
The vaginal microbiome influences health and disease of the female reproductive tract, and there is emerging evidence of the involvement of
vaginal microbiota in the risk of persistent HPV and subsequent development of cervical cancer.
Furthermore, additional studies are needed to elucidate the causal role of
vaginal microbiota in HPV status and progression to cervical cancer.
Not exact matches
Other mechanisms at play may include changes
in the
vaginal microbiota induced by progesterone — specifically, a reduction
in hydrogen peroxide - producing Lactobacillus, which can kill HIV.
While there are trends
in certain
vaginal microbiota and increased risk
in acquiring transient and persistent HPV infections, current studies are heterogenous
in nature and describe relatively small numbers of cohorts with limited control groups.
The association between ethnicity and
vaginal microbiota composition
in Amsterdam, the Netherlands — Hanneke Borgdorff — PLoS One