Sentences with phrase «validate gene targets»

«The ability to identify, characterize and validate gene targets that strongly associate or correlate with disease development or metastasis will facilitate early detection and appropriate treatments to tackle the disease at an early stage or before metastasis occurs.»

Not exact matches

To validate their findings, the scientists injected the novel nanoparticles into pancreatic tumor - bearing mice and observed that by balancing these two targets — bringing them to a normal level by increasing their expression or blocking the gene responsible for their expression — they significantly prolonged the survival of the mice.

Derived mostly from human embryonic kidney 293T (HEK293T) and HeLa cell lines, EdiGene Knockout (KO) Cell Lysates have been optimized through the use of genome editing technology and validated at the genomic level through PCR and Sanger - sequencing techniques to ensure the accuracy and knockout of the target gene.

Among the genes they validated as transcriptional targets of RORA is the gene for aromatase, an enzyme that converts male to female hormones.

Then the researcher can ask the database for validated or predicted genetic targets of microRNAs, or for validated / predicted microRNAs that regulate specific genes.

While advancing this target discovery work, deCODE will also bring to the alliance its Clinical Genome Miner ™ system in order to validate and prioritize targets emerging from Merck's substantial research programs in mice and gene - expression.

Tamara Caspary, a developmental biologist and scientific director of Emoryâ $ ™ s transgenic mouse and gene targeting core, says she and her core team are in the process of developing and validating CRISPR, so that the technique could be accessible to many Emory investigators.

This is a great example of a potential gene therapy target that still needs a fair amount of work to validate the thesis and the initial data, but having a large number of existing human carriers is a good sign on the safety front.

We help our clients better understand the function of genes, basic mechanisms of biology, pathophysiology of diseases, to identify and validate new drug targets and to perform risk assessment in drug development.

The service provided covers the production of a minimum of two heterozygous mice carrying the targeted gene allele of choice from the corresponding validated gene - targeted ES cell clone (s).

These knockout cell lines allow researchers to quickly validate their gene or target of interest, without having to invest time and resource in developing in - house CRISPR technology.

Focused on meeting this urgent unmet medical need, ALS TDI executes a robust target discovery program, while simultaneously operating the world's largest efforts to preclinically validate potential therapeutics; including a pipeline of dozens of small molecules, protein biologics, gene therapies and cell - based constructs.