Sentences with phrase «validated models of human diseases»

Not exact matches

The researchers» strategy — generating disease - specific nerve cells, identifying a causative gene for developmental defects, validating the gene - specific defect in animal models, and then investigating interactions with other genes both in animal models and in humans — represents a promising new approach for understanding the mechanisms underlying some of the most intractable psychiatric illnesses.

These mouse models are useful tools to improve our understanding of the biological significance and functional relevance of these polymorphisms in human disease, particularly when validated with controlled exposures and environmental challenges.