Sentences with phrase «validation of»

Registration of cell lines in hPSCreg will provide visibility, confidence in ethical provenance, validation of characterization data and comparability with other registered lines.

The development and validation of new risk scores with sex - specific weighting of risk factors could be a promising tool for future prediction models.

... [P] erfect validation of dependency and stationary tests endorses the applicability of the Markov chain analyses on Sunspots and ENSO data.

Despite exploiting signatures displaying different statistical properties, these methods individually detected genes previously identified as undergoing selection in domesticated horses, such as KITLG (9) and melanocortin 1 receptor (MC1R)(40), providing important validation of the approach as a whole.

We carried out validation of the model using a variogram - based procedure, which tested the compatibility of the adopted spatial structure with the data.

Validation of Cyclin D1 / CDK4 as an anticancer drug target in MCF - 7 breast cancer cells: Effect of regulated overexpression of Cyclin D1 and siRNA - mediated inhibition of endogenous Cyclin D1 and CDK4 expression.

This toolbox can be used for a wide variety of applications including drug discrimination, validation of experimental medicine models and patient stratification.

The phenotyping platforms of PHENOMIN - ICS area, adapted to study genetically modified mouse models, can also be used for preclinical studies, including the validation of therapeutic targets, as well as pharmaceutical and toxicological studies in mice.

C: Technical validation of the expression data from the array with qPCR.

B — E: Technical and biological validation of six metabolically relevant genes selected from among the ones with the largest expression differences in adipose tissue of diabetic vs. nondiabetic co-twins.

The ICS is a large - scale facility open to the community that ensures the generation of mouse models à la carte, the validation of genetic models, the expansion and preservation and distribution of models with the housing department, and offers in its phenotyping department a series of standardized functional analysis of mouse models that can be performed in a comprehensive pipeline or on demand, as well as for more specialized studies, that cover the major functions and key physiological systems.

The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM - IV and ICD - 10.

Title: Validation of 11C - ORM - 13070 as a PET tracer for a2C - adrenoceptors in the human brain Author: J. Lehto et al..

He is working on the prediction and validation of conserved T cell epitopes from prevalent swine influenza viruses.

«The significant problems due to poor validation of antibodies have recently been brought to the headlines by major journals, including Nature.

The Institute's phenotyping platforms are adapted for the study of mutant mice and genetic reference populations but can also be used for preclinical studies including the validation of therapeutic targets as well as pharmacological and toxicological studies in the mouse.

«This is the first biological validation of a computational model developed in the early 1980s that suggested that two such forces would be necessary to guide axons as they establish the connections that relay spatial information from one part of the nervous system to another,» said study author Yimin Zou, PhD, assistant professor of neurobiology at the University of Chicago.

Validation of Kepler's Multiple Planet Candidates.

Dissertation work led to phenotypic validation of a novel gene for the scale - up and expansion of stem cells.

Design and validation of a bioreactor for simulating the cardiac niche: a system incorporating cyclic stretch, electrical stimulation, and constant perfusion.

Validation of N - myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach.

This material is intended for use as an internal flow cytometry control for detection of intracellular cytokines and validation of techniques.

Position Description: The University of Vigo offers a Research Position in Vigo (Spain) to work with the Laboratory of Remote Sensing and GIS on the H2020 research project CoastObs in validation of Sentinel 3 data in order to provide information about the relationship between environmental conditions in HABs blooms and develop of local CASE 2 chl - a models.

Development and validation of a modular 3D microenvironment platform technology for studying prostate cancer - induced bone metastasis.

We report here the characterization of an USP planet with a period of 0.28 days around K2 - 141 (EPIC 246393474), and the validation of an outer planet with a period of 7.7 days in a grazing transit configuration.

The University of Vigo will: - Provide a comprehensive validation of the developed within CoastObs products, to complement the validation of Standard Ocean colour products generally over coastal waters and to determine the magnitude and stability of associated errors and uncertainties.

Validation of the immunological role of these epitopes is in the process.

We also statistically validate 18 planets (eight of which were previously unpublished), confirm the earlier validation of 21 planets, and announce 17 newly discovered planet candidates.

«We are excited to work with deCODE on this important initiative to obtain human validation of targets and to dissect the heterogeneity of obesity,» said Stephen Friend, M.D., Ph.D., Vice President of Molecular Profiling at Merck and President of Rosetta Inpharmatics.

The study focuses on the discovery, confirmation and validation of novel biomarkers in a non-interventional manner applying NGS, multiplex PCR and miRNA technologies to determine the biomarkers according to free circulating DNA, RNA, miRNA of maternal plasma, serum and white blood cells along with the use of extracellular vesicles.

Evaluation and validation of candidate gene products entail elucidation of their functional networks and mechanisms of action.

The HZI will provide expertise and technologies for adjuvants and the preclinical validation of vaccine technologies and candidates in murine systems.

«We are delighted to have the support of such an esteemed group of new and current investors, and view the caliber of the participants as further validation of the potential of our CRISPR - Cas genome engineering platform to transform the development of new medical therapies and bio-based products,» said Rachel Haurwitz, Ph.D., President and Chief Executive Officer and co-founder of Caribou.

Unfortunately, no validation of this temperature record has been given.

True validation of a target mechanism (eg.

The Ospedale San Raffaele Mouse Clinic (OMC) is the follow - up and consolidation of a Regione Lombardia - funded project (EMDM), which aimed at the establishment and implementation of a large, dedicated facility (the European Mouse Disease Models Center) whose goal is the development and functional assessment of mouse disease models, both for the dissection of the underlying pathogenic mechanisms and for the screening and validation of innovative diagnostic and therapeutic procedures.

In closing, I would like to appeal to peer reviewers of those journals who now wish to see functional validation of genomic findings.

CancerSeq tissue samples provide researchers with a medium for applications including validation of cancer marker mutation related drug candidates

This presentation will outline from the perspective of MP regulators the scientific - regulatory challenges for technical validation of CDx.

Besides the detailed analysis of antibody responses, the training will address the development and validation of quality control and quantification assays.

Functional validation of the human mutation was done in developing zebrafish.

After successful prototype implementation, verification and validation of the new methods, these will be implemented in an open source library and transferred to leading application codes in order to improve their predictive capabilities and physical correctness.

Funds will be used for assay development and clinical validation of a novel molecular test useful for stratifying patients with glioblastoma.

Note also that this result was nowhere built in to the analyses and so to find that the most consistent readings produce just that is a validation of all the approaches.

Our goal is to help scientists who want to use this technology for gene editing by summarizing current advances on many technical aspects, from the RNA guide optimized design to the genotyping analysis and the validation of the newly generated models.

The Showe Laboratory will be performing the optimization and validation of the prototype glioblastoma diagnostic test, transferring the assay to a more versatile technology platform that is better suited for clinical applications.

This, in my opinion, is one of the most compelling parts of this study: in vivo functional validation of a single base change in a noncoding enhancer that's hundreds of thousands of bases away from the gene it regulates.

«This is a validation of the whole K2 program's ability to find large numbers of true, bona fide planets,» said Ian Crossfield, an astronomer at University of Arizona, said during the American Astronomical Society's annual meeting, at which the find was announced.

IDMIT will contribute 1) To the development and validation of assays based on flow cytometry and mass cytometry for the evaluation of immune responses in humans and animal models; these tools will be particularly relevant for the identification of signatures of vaccine efficacy; 2) To the animal model platform, in particularly by providing access to NHP models and to new technologies for in vivo imaging infections and host responses; 3) To networking activities, in particular by organising a workshop on in vivo imaging.

«Laboratory experiments with human subjects can provide empirical validation of individual decision rules of agents, their interactions and emergent macro behavior», says Cars Hommes, who leads a group of behavioral economists at the University of Amsterdam.