Sentences with word «valproate»

Preclinical evidences for a beneficial impact of valproate in response of small cell lung cancer to chemotherapy.

Of those children, 64 were exposed to valproate in utero, 44 to lamotrigine, 76 to carbamazepine, and 65 to other epilepsy drugs or combinations of drugs.

Compared to children whose mothers did not have epilepsy, the risk of autism was seven times higher in those with valproate exposure.

In the study, less than 1 % of women without epilepsy had a child with autism, compared with 6.3 % of women with epilepsy who had taken sodium valproate during pregnancy.

Study of the effect of valproate on pulmonary cancer cells, in combination with chemotherapy agents.

Preliminary but promising data suggest that certain medications, including such mood stabilizers as Valproate, can alleviate the interpersonal and emotional volatility that characterize BPD, according to a 2010 review by psychiatrist Klaus Lieb of University Medical Center in Mainz, Germany, and his colleagues.

The seizure drug valproate and capsaicin cream, which were considered probably effective in the 2011 AAN guideline, were ineffective in this meta - analysis.

Of these 171 women, 42 had taken levetiracetam, 27 had taken topirimate and 47 had taken valproate while pregnant — an additional control group of women with similarly - aged children who had not taken any antiepileptic drug while pregnant was also included in the study.

«Over the past few years, doctors have been moving away from prescribing valproate to pregnant women, shifting them to the two newer antiepileptic drugs.

Morland C, Nordengen K, Gundersen V (2012) Valproate causes reduction of the excitatory amino acid aspartate in nerve terminals Neurosci Lett, 527 (2), 100 - 4 PubMed 22963924

Autism Speaks is currently funding a number of studies that examine whether prenatal valproate exposure produces behavioral deficits in animals.

'' [Then] research can turn to the ways in which women who can not stop or reduce [valproate] treatment while pregnant can ameliorate the risk of birth defects,» Halladay says.

Alycia Halladay, PhD, the director of research for environmental sciences at Autism Speaks, an advocacy group that raises money for biomedical research, says the study «adds to the growing literature that in utero exposure to [valproate] may be one possible risk factor for autism.»

Valproate increases pro-apoptotic efficacy of chemotherapeutic regimen in small cell lung cancer.

Valproate treatment of human cord blood CD4 - positive effector T cells confers on them the molecular profile (microRNA signature and FOXP3 expression) of natural regulatory CD4 - positive cells through inhibition of histone deacetylase.

Valproate reduces alcohol consumption in people with comorbid alcohol dependency and bipolar disorder

A report from 2005 documented the case of a 54 - year old man who started the Atkins diet while on valproate medication.

Also as a political psychopath he says he is willing to press the nuclear button to valproate millions of human beings — men, women and children at a stroke thus alienating millions of voters who are anti-war!

«First - choice drugs are usually beta - blockers such as propranolol and metoprolol, the anticonvulsants valproate and topiramate, and the calcium channel blocker flunarizine.

The drug — a mood stabilizer called valproate — is commonly prescribed to treat bipolar disorder and schizophrenia, though its mechanism of action is poorly understood and only some patients respond to the treatment.

In the roughly 40 percent of patients with this genotype, higher levels of proline (a neuromodulator that is increased by valproate), correlated with fewer negative symptoms.

Medication with lithium and valproate prevents manic phases and has mood - stabilizing effects.

Depakote and other Valproate drugs have been linked to side effects that include serious birth defects.

The researchers also evaluated negative symptoms in 43 patients with bipolar disorder, about half of whom were treated with valproate.

Ketogenic diet - induced toxicity of the anticonvulsant medication sodium valproate has been reported (30) however these treatments can be used together without problem in most cases (31).

«This information may help to determine which patients may be most likely to benefit from treatment with mood stabilizers such as valproate that are known to modulate proline levels.»

Efficacy of aripiprazole versus placebo as adjuncts to lithium or valproate in relapse prevention of manic or mixed episodes in bipolar I patients stratified by index manic or mixed episode

The study of 6,671 individuals found lower rates of self - harm and unintentional injuries among those patients taking lithium compared with those prescribed valproate, olanzapine or quetiapine.

Depakote / depakane / valproate causes shortages in l - carnatine, folate, vitamin E and sometimes selenium, and the low folate causes anemia — specifically (in me) low hematocrit or hemoglobin levels, rarely both.

Additionally, we found that many of the respondents who were not taking precaution of neural tube malformation were taking Valproate, a folic acid antagonist,» said Andrew G. Herzog, MD, principal investigator of the study.

Neural tube malformations are most common with the use of Valproate, a folic acid antagonist.

The study helps determine the effects of CBD in combination with common AEDs, including carbamazepine, valproate, levetiracetam, clobazam and lacosamide.

However, the valproate group had an average IQ 11 points lower than the control, levetiracetam and topirimate cohort.

The authors conclude that valproate may be effective for treating negative symptoms in psychiatric patients with two copies of the «Val» variant of the COMT gene, which breaks down dopamine in the brain.

Among those patients who were being treated with valproate (approximately one - third of the schizophrenia patients), negative symptoms were more severe in those with the Met / Met gene than in those with the Val / Val gene.

In patients who have a «Met» variant of COMT, rising levels of proline appeared to do the exact opposite: these patients had more or worse negative symptoms, and the symptoms did not improve with valproate.

Valproate, one of the most commonly prescribed antiepileptic medications, has been associated in the past with birth defects and developmental problems.

Joseph F. Hayes, M.Sc., M.B.Ch.B., of University College London, England, and coauthors compared rates of self - harm, unintentional injury and suicide deaths in patients prescribed lithium, valproate sodium, olanzapine or quetiapine using a large database of electronic health records in the United Kingdom.

A common mood - stabilizing drug, valproate, is found to control manic - like behavior induced in mice with an extra copy of a gene called SHANK3

They also gave the bipolar drugs lithium and valproate to mice, and investigated the effects on their brains.

Because both phenylbutyrate and another weak HDAC inhibitor, valproate, are FDA - approved, clinical trials of these agents started rapidly.

Valproate in the treatment of acute mania.

Patients taking lithium had lower rates of self - harm and unintentional injury compared to those taking other bipolar drugs, such as valproate (Depacon, Depakote), olanzapine (Zyprexa) or quetiapine (Seroquel), said lead researcher Joseph Hayes.

And people on valproate or quetiapine were 32 percent to 34 percent more likely to fall victim to unintentional injury, most likely while experiencing a manic episode, the researchers said.

To compare lithium against newer medications, Hayes and his colleagues collected medical data on nearly 6,700 people diagnosed as bipolar and prescribed only one of the drugs — lithium, valproate, olanzapine or quetiapine.

First line drugs used in the treatment of a migraine include propranolol, topiramate, Divalproex / sodium valproate, and metoprolol.