Previous studies found that patients with
valve calcification have shorter telomeres than healthy individuals of the same age.
«Drug developed for arthritis could be first to stop heart
valve calcification.»
David Merryman, associate professor of biomedical engineering, wants permission to do clinical trials using a rheumatoid arthritis drug to stop heart
valve calcification.
Not exact matches
It begins as aortic sclerosis, a thickening of the aortic
valve by
calcification.
Scientists have long known that blood flow in the heart plays a role in the
calcification of
valves and arteries, but they did not understand how.
The first drug to treat
calcification of heart
valves may be one originally designed for rheumatoid arthritis.
The Ph.D. students obtained heart
valves preserved from surgeries at Vanderbilt University Medical Center and found that patients suffering from
calcification had, in some cases, 50 times as much CDH - 11 present in their
valves as patients without the condition.
«Identifying these master regulators is a big step in treating CAVD, not just in people with the NOTCH1 mutation, but also in other patients who experience
calcification in their
valves and arteries,» says Dr. Srivastava.
Matrix Gla protein regulates
calcification of the aortic
valve.
Dr. Schoen's areas of medical research include cardiovascular pathology, cardiovascular biomaterials and host - biomaterial interactions, heart
valve substitutes and other technology for structural heart and vascular disease,
calcification of bioprosthetic tissues, heart transplantation, and cardiovascular tissue engineering.
In previous studies, The Srivastava lab showed that mutations in the gene, NOTCH1, cause birth defects that affect the heart
valve and cause the
calcification to take place sooner.
In some cases, the heart
valve is just thickened, but in others, it can harden by a process called
calcification that is similar to that when bone is made.
Future studies should directly investigate whether exercise increases the activation of vitamin K - dependent proteins, but it seems reasonable to suggest that part of the reason exercise promotes cardiovascular health may be because it ensures a more abundant supply of carbon dioxide, which vitamin K uses to activate proteins that protect our heart
valves and blood vessels from
calcification.
What's more, recent news headlines in the New York Times and other major publications have warned against calcium supplements for reasons ranging from pain from kidney stones to death by heart attacks and stroke caused by
calcification of the arteries and heart
valves.
Found Linus Pauling's Therapy for Heart Disease and am wondering if it might help the
calcification of my aortic
valve.
Life Extensions and cardiologist say that calcium supplements to prevent osteoporosis do not contribute to
calcification of heart
valves.