Sentences with phrase «variant gene effects»

Not exact matches

This team also discovered 3,200 genes that had fewer loss - of - function or missense mutations than would be expected suggesting that these are likely disease - causing variants that are rare or absent in the population because of their detrimental effect on human health.

Variants of one gene had a major effect on rapid changes in beak size after a drought, researchers report in the April 22 Science.

«So, a variant of gene with a positive effect on intelligence, has a negative effect on schizophrenia, body mass index or obesity.»

«We wanted to use pharmacologic means to get the same effect as the gene variant,» says Alban Latremoliere, PhD, also of Boston Children's Kirby Center, who led the current study along with Woolf and Costigan.

They found that people with the gene variant had the highest risk of side effects when they were given a statin called simvastatin, but this risk was much lower when they took pravastatin.

They then examined genetic variants throughout the human genome for their effects on gene expression in these two representative populations of immune cells.

What we need to do now is to see if other circadian gene variants in association with different stress factors cause the same effect.

While previous investigations into the protein's effects have used either mice in which gene expression was knocked out or transgenic animals that expressed human gene variants throughout their lifetimes, the MGH - MIND - led study used a different approach to investigate the effects of introducing the variant forms of the protein into brains in which plaque formation had already begun.

A study of the interplay between peer drinking and the functional polymorphism rs1229984 in the alcohol dehydrogenase 1B gene (ADH1B) in the development of adolescent drinking milestones has found that peer drinking reduces the protective effects of an ADH1B variant.

Common gene variants that have minor effects may contribute about half the risk of developing autism

However, the new, larger study found that the effect of viral replication capacity was very early after infection, and was independent of both initial viral load and whether individuals carried certain protective variants of immune genes called HLA that positively influence immune responses to HIV.

«There are no common variants with large effects,» says Lavinia Paternoster, a geneticist at the University of Bristol in the United Kingdom, who plans to work with Kayser in the future on finding more facial genes.

Bronstein said the team also found that people with a common genetic variant of the ALDH2 gene are particularly sensitive to the effects of ALDH - inhibiting pesticides, and were two to six times more likely to develop Parkinson's than those without the variant when exposed to these pesticides.

The effects of this previously discovered gene variant were analysed by utilising data from the unique and extensive METSIM study.

«This research is an important addition to the field because previous studies looking at CYP gene variants and their effects on risks of repeat heart attacks, bleeding and death have included predominantly Caucasian patients of European ancestry,» Cresci noted.

«Research team evolves CRISPR - Cas9 nucleases with novel properties: Engineered variants of gene - cutting enzyme double the targeting range, reduce off - target effects.»

Comparing DNA from 2066 people with Crohn's and 3633 people without it, the team identified two variants of the same gene, called LRRK2, with differing effects.

«There are hundreds of candidate genes to sort through, and a single genetic variant may have different effects even within the same family.

A variant in a region of the genome that is not coding for a protein can have a relatively large effect on a gene regulating bone health,» says Dr. Douglas Kiel, whose NIH - funded team at Hebrew SeniorLife and Harvard Medical School played a key role in the effort.

No association was found between the genetic risk score and lifestyle factors and testing confirmed that only the abdominal adiposity effects of the identified gene variants were associated with cardiometabolic risk.

According to Andreassen, the study's senior author, some think of schizophrenia as a «side effect» arising from advantageous variants in genes that are related to the development of human traits, such as cognitive and language skills, that may have increased risks for developing psychoses.

They applied a strategy for seraching genes with multiple rare (minor allele frequency < 0.001) variants in cases but not in controls with a potentially damaging effect.

Prior to joining CRI, Vanessa was a postdoctoral fellow at NYU School of Medicine, studying the role of a common gene variant and its effects on Graft - Versus - Host - Disease.

It's a complicated picture, to be sure, but it suggests some specific areas in which noncoding variants are exerting a cis - regulatory effect on the LPA gene.

This idea is intuitive: in theory, large - effect variants would be kept at low frequency by natural selection, a pattern that's well established for mutations that cause rare single - gene disorders.

The trial was designed to examine the effect of various doses of DG031 on certain biomarkers linked to arterial inflammation and risk of heart attack in patients with a history of heart attack and one or more of the gene variants deCODE has linked to increased risk of the disease.

As a result, the misidentification of genetic variants associated to the Neolithic spread and the effect of post-Neolithic expansions in the genetic make - up of Europe could have introduced important biases in the estimations of the Neolithic component of the European gene pool producing misleading conclusions [22].

It is extremely difficult to demonstrate that such variants are actual mutations affecting genes, as they could simply be random DNA changes that have a neutral effect.

The researchers observed a sequence variant in a previously unidentified gout susceptibility gene located on chromosome 19 that has a large effect on serum uric acid levels and gout.

The gene closest to these variants is TMEM18, although the molecular mechanisms mediating these effects remain entirely unknown.

In this study, the research team searched for gene mutations - or other variations in the genome - that may have a direct effect on the risk of pathologically low - bone density among a large set of sequence variants.

«This one gene variant only has a small effect on facial aging overall,» said Gunn.

Interaction effects were significant for 2 maternal genes, which included a well researched variant on the methylenetetrahydrofolate reductase gene linked to increased levels of the amino acid homocysteine and less efficient folate metabolism.

CONCLUSIONS: Early - onset antisocial behavior in a high - risk clinical group is predicted by a specific COMT gene variant previously linked with prefrontal cortical function and birth weight, and those possessing the val / val genotype are more susceptible to the adverse effects of prenatal risk as indexed by lower birth weight.

RESULTS: The results show main effects of the COMT gene variant (P =.002), birth weight (P =.002), and a significant gene x environment (COMT x birth weight) interaction (P =.006).