Sentences with phrase «variants of a single gene»

Now, a study led by a researcher at the Salk Institute has found that variants of a single gene can largely determine a plant's ability to thrive in environments where iron is scarce.

Not exact matches

No particular genetic variant was shared across all synesthetes in all three families, suggesting there is no single «synesthesia gene» or set of genes.

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

In all, the study included the data of more than 23,000 people to show that approximately 12 percent of a person's variation in delay discounting can be attributed to genetics — not a single gene, but numerous genetic variants that also influence several other psychiatric and behavioral traits.

Although the gene sequences were not identical to the Mikovits - Ruscetti XMRV gene sequence reported in Science, they were so close Lo believed he had found genetic variants of a single MLV - like virus species that likely included XMRV.

In many cases, the activity of particular genes was tied to a single genetic variant, with strong differences in frequency between European and African populations.

Fifty - four per cent were single gene mutations, and the other 13 per cent were polygenic DNA variants, meaning they were a combination of multiple bad genes inherited together.

Hereditary predisposition to cancer is sometimes due to a single high - risk genetic change, like a mutation in the BRCA1 or BRCA2 genes for breast cancer, but most of the time, the disease is the result of multiple gene variants that add up, environmental risk factors, and a big element of chance.

He has worked in the biotech industry as a research scientist for over 11 years with a focus on emerging technologies including gene targeting in mice, molecular analysis of transgenes using GFP variants at the single cell level, and developing flow cytometry reagent kits to speed up assay development time for researchers.

«Identifying these gene variants linked to both type 2 diabetes and CHD risk in principle opens up opportunities to lower the risk of both outcomes with a single drug,» said study co-senior author Danish Saleheen, PhD, an assistant professor of Biostatistics and Epidemiology.

Thus µSCALE empties the contents of a single capillary onto a collector plate, where the DNA of the isolated cell can be sequenced and the gene variant responsible for the protein of interest can be identified.

A copy number variant may affect dozens of genes, or it can disrupt or duplicate a single gene.

«There are hundreds of candidate genes to sort through, and a single genetic variant may have different effects even within the same family.

Other medical sequencing projects will use DNA sequencing to: discover new genes that are involved in common diseases; identify the genes responsible for dozens of relatively rare, single - gene (autosomal Mendelian) diseases; sequence all of the genes on the X chromosome from affected individuals to identify those involved in sex - linked diseases; and survey the range of variants in genes known to contribute to certain common diseases.

The results also showed that polymorphism, a genetic variant that can change the way a particular gene functions, is possible under a wide range of conditions, which results in a single population playing a variety of different behavioral games.

Cardiomyopathy can be caused by a single mutation in any one of a number of genes, each one resulting in a slightly different variant of the disease.

Sequencing accelerates the analysis of cancer associated alterations in genome sequence such as insertions and deletions, CNVs, inversions, duplications, translocations and gene fusions, as well as single nucleotide variants.

Because you have her whole genome, and not just a test for a single gene, you can potentially look for a vast number of other gene variants that raise the risk of other diseases of adulthood, such as the BRCA1 gene for breast cancer.

The investigators found that people who carry a single copy of the KL - VS variant of the KLOTHO gene, roughly 20 percent of the population, have more klotho protein in their blood than non-carriers.

The researchers found that people who carry a single copy of the KL - VS variant of the KLOTHO gene perform better on a wide variety of cognitive tests.

The researchers discovered a single letter variant located in TP53, a gene known to play a central role in tumor biology and for accumulating so called somatic mutations, during the development of cancer in patients.

The alliance will employ Illumina's platform for high - multiplex single - nucleotide polymorphism (SNP) genotyping to develop tests for gene variants deCODE has previously shown to have impact on the risk of a growing number of common diseases with major public health impact.

In each case they checked tiny sites of known DNA - sequence variations — «single nucleotide polymorphisms» — that mark common gene variants.

Multiple transcripts arising from alternative initiation or polyadenylation sites, or alternative RNA splicing at a single locus were not considered as multiple genes but as variants of a single transcription unit.

Studying a specific type of genetic variation in the DNA sequences of wolves and domestic dogs - called Single Nucleotide Polymorphisms (SNPs)- the scientists identified the transfer of dog gene variants into wolf genomes.

In the first paper, utilizing genomic analysis of nearly 8,500 Icelandic and Dutch participants, the deCODE team identified a novel, tightly - linked pair of single - letter variants (SNPs) near the ASIP (agouti signaling protein) gene on chromosome 20 that greatly increase the likelihood of an individual being prone to freckles and sunburn.

Compounded by the fact that a single variant might affect multiple transcripts / genes, the number of observed human coding variants exceeds 22 million.

In a new study, Sklar and her colleagues are scanning 500,000 gene variants, known as single nucleotide polymorphisms, obtained from a sampling of patients with bipolar disorder.

First, Dr. Shendure described some interesting experiments under way in his lab to elucidate the function of non-coding regulatory variants — specifically, single nucleotide changes in the core promoter that alter gene transcription.

Carrier testing can be ordered in various ways, including targeted single gene disease testing, panel testing of multiple genetic diseases, or less commonly through a broad genomic test looking for genetic variants throughout the genome or exome.

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence variation.

To explore the possibility of common genetic pathways within the respective pathophysiologies, nine ADHD candidate single nucleotide polymorphisms (SNPs) in seven genes were tested for association with PD in 5333 cases and 12,019 healthy controls: one variant, respectively, in the genes coding for synaptosomal - associated protein 25 k (SNAP25), the dopamine (DA) transporter (SLC6A3; DAT1), DA receptor D4 (DRD4), serotonin receptor 1B (HTR1B), tryptophan hydroxylase 2 (TPH2), the norepinephrine transporter SLC6A2 and three SNPs in cadherin 13 (CDH13).

No single non-synonymous (NS) single nucleotide variant (SNV) nor any gene carrying a higher burden of NS SNVs was significantly associated with PD status after multiple - testing correction.

Methods.: Dogs of various breeds, affected or unaffected with primary glaucoma, were genotyped for the Gly661Arg variant of ADAMTS10, as well as 7 other nonsynonymous single nucleotide polymorphisms (SNPs) in other genes in the beagle POAG locus that segregate with disease.