Sentences with phrase «variations in gene expression»

The main molecular alterations are represented by variations in gene expression, usually mild and with consequences for a vast number of target protein coding genes.

Variations in gene expression could be attributable to the drastic environmental change.

The research team demonstrated that ranking genes based on inter-tumor variation in gene expression outperforms traditional analytical approaches.

Across all four cancer types, the new method of selecting candidate genes based on inter-tumor variation in gene expression outperformed the other methods, including the standard method of comparing mean expression in adjacent normal and tumor tissues.

Home > Press > Single - cell mRNA cytometry via sequence - specific nanoparticle clustering and trapping: Cell - to - cell variation in gene expression creates a need for techniques that can characterize expression at the level of individual cells

Not exact matches

Therefore, variation in RNA quality across lactation stage must be considered when interpreting gene expression results across postpartum time points.

The team also looked at gene expression before and after exposure and identified 335 genes whose variation in expression correlated with caspase activity.

Analysis showed that incremental changes in the number of repeats caused non-harmful variations in the expression of the genes regulated by Ssn6.

Indeed, the team identified high variation in adjacent «normal» tissue samples, which are typically used as control samples for comparison in analyses based on mean gene expression.

Additionally, researchers found that nearly 300 genes showed variation in their expression in heart tissue over the course of a day — a possible basis for the tissue's change in behavior.

In the study, they additionally confirmed that nearby genetic variation in the form of cis - eQTLs affected expression of about 50 percent of genes in the sampleIn the study, they additionally confirmed that nearby genetic variation in the form of cis - eQTLs affected expression of about 50 percent of genes in the samplein the form of cis - eQTLs affected expression of about 50 percent of genes in the samplein the samples.

An international consortium of researchers in the Genotype - Tissue Expression (GTEx) Consortium published findings about how genetic variation effects gene regulation in 44 human tissue types.

In contrast, cis - eQTLs — which account for the majority of genetic variation that affects gene expression — regulate genes located nearby on the same chromosome.

Natural variation exists in the levels of pectate lyase gene expression in wild relatives of cultivated tomato and these can be used for conventional breeding purposes.

Correlation of gene expression occurred across lean and obese mice, defining a common transcriptional response to variations in adiposity.

These data demonstrate that variations in continuous quantitative traits such as body mass, adipocyte size, and BMI are correlated with quantitative variations in the expression of genes.

Professor Dermitzakis» research focuses on the genetic basis of regulatory variation and gene expression variation in the human genome, the processes that govern non-coding DNA evolution.

With all of the SNP genotypes in hand, researchers could assess gene expression — initially with microarrays, and later with RNA - seq — and then correlate it with genetic variation.

Variation in expression levels of these genes was also observed in human blood samples, though the variation was in opposite phase of the mouseVariation in expression levels of these genes was also observed in human blood samples, though the variation was in opposite phase of the mousevariation was in opposite phase of the mouse studies.

Unpaired student's t - test was also used to compare gene expression variation in siTRF2 silenced versus non silenced scrambled siRNA HCT116 cells in the presence of bleomycin sulfate.

Part of the normal variation, which is equally present between blastocysts of both groups, can be observed in the gene expression of levels mtDNA encoded OXPHOS proteins.

We expanded on our genome sequencing efforts to include efforts in whole genome gene expression analysis and functional analysis of genome variation.

Further, his group pioneered expression quantitative trait locus (eQTL) studies, which enabled variation in global gene expression to be applied to genetics of complex human diseases.

In order to assess the impact of PMI on gene expression we need to account for the possible effect of other pre-mortem variables on the variation of gene expression.

Changes in gene expression as a response to death, and during subsequent post-mortem ischemia, might be expected to reflect stochastic variation resulting from the enzymatic processes underlying mRNA degradation.

For the 374 expressed genes, we find many regions with statistically significant association of single nucleotide polymorphisms (SNPs) with expression variation in lymphoblastoid cell lines after correcting for multiple tests.

Our first striking observation was that over one half of measured genes are affected by common genetic variation in human populations — called expression quantitative trait loci or eQTLs.

The resulting datasets of regulatory genomic sequence will provide a valuable resource in determining how non-coding DNA sequence variation may impact an individual's capacity to drive appropriate gene expression.

The gene - of - interest is first inspected on three aspects in the BXD GRP, i.e. the existence of genetic variations, e (p) QTLs, and its expression pattern across strains.

Our objective is to determine whether this mutation is involved in AMD by (1) understanding the functional consequences of this genomic variation on expression of COL8A1 and / or its neighbor genes, and (2) investigating photoreceptors and RPE cell survival, retinal and choroidal angiogenesis, structure integrity of the choroid / Bruch's membrane, and the quality of the vision, in organisms with the COL8A1 mutation.

By utilizing paired genome - wide high - throughput DNA sequencing (DNA - seq) with RNA - seq, we found that gene dosage, at the level of individual genes or chromosomal «somy» (a general term covering disomy, trisomy, tetrasomy, etc.), accounted for greater than 85 % of total gene expression variation in genes with a 2-fold or greater change in expression.

«The new studies complement the current GTEx project in assessing genomic variation and gene expression,» explained Simona Volpi, Pharm.D., Ph.D., GTEx program director in the Division of Genomic Medicine at the National Human Genome Research Institute (NHGRI), which helps administer the program.

Here, the authors use single - cell RNAseq and ChIPseq to find that actively transcribed genes with Polycomb marks have greater cell - to - cell variation in expression.

Genetic hybridization has been demonstrated to yield dramatic structural genomic variation, but whether such changes in gene dosage impact gene expression has not been formally investigated.

We find that Polycomb repressive complex - active genes have greater cell - to - cell variation in expression than active genes, and these results are validated by knockout experiments.

The present study shows that such a gradient is also seen at the level of single cell analysis, but reveals that there is considerable cell - to - cell variation within this gradient in the expression of pluripotency genes.

Insecticide resistance is typically associated with alterations to the insecticidal target - site or with gene expression variation at loci involved in insecticide detoxification.

Recently, groups have leveraged high - throughput gene expression and genotyping technologies to perform genome - wide assocation studies of gene expression, in which gene expression levels are considered a quantitative trait and significant correlations to SNP variation are identified.

However, gene variations, the presence of strain - specific genes, and the occurrence of plasmids in strain GP59 could affect the expression pattern of these common genes.

In fact, a recent study by Arakawa and colleagues of thyroid patients with Hashimoto's and Graves» found that polymorphisms — that is, gene variations that may lead to the abnormal expressions — were as common in autoimmune thyroid disease as they were in the normal populatioIn fact, a recent study by Arakawa and colleagues of thyroid patients with Hashimoto's and Graves» found that polymorphisms — that is, gene variations that may lead to the abnormal expressions — were as common in autoimmune thyroid disease as they were in the normal populatioin autoimmune thyroid disease as they were in the normal populatioin the normal population.

Since the problem in atopic dermatitis is gene variation, preventing the expression of this gene can help improve the signs and symptoms associated with canine atopic dermatitis.

To further make their case, the LRC notes that the first Labrador retriever breeder who started regularly producing the silver colored variations was also a breeder of purebred Weimaraners, a breed in which the dd gene expression is always present and parents can ONLY pass down a d allele.

Within the gene coding for MAOA, there is a particular form of variation (referred to as the MAOA - uVNTR) that is associated with differences in the expression of the MAOA gene (Sabol et al., 1998).

In relation to the association of infant attachment with a promoter polymorphism of the serotonin transporter gene, we have mentioned that gene expression may be affected by variation in the DNA sequence of the regulatory region of the genIn relation to the association of infant attachment with a promoter polymorphism of the serotonin transporter gene, we have mentioned that gene expression may be affected by variation in the DNA sequence of the regulatory region of the genin the DNA sequence of the regulatory region of the gene.

Moreover, they have shown that, through differential patterns of DNA methylation of the promoter region and thereby differential expression of the estrogen receptor alpha gene in the medial preoptic area (MPOA) of the brain, this individual variation of early experience influences adult reproductive behaviour, suggesting a mechanism for intergenerational transmission of the pattern of maternal care [137, 138].

Allelic variation in this transporter's gene expression, regulated by a 43 bp indel in the upstream region termed 5 - HTTLPR, was initially associated with anxiety - related traits (23) and has since been investigated in many fields of serotonin - related human genetics (24).