Having been excited by the potential of retroviral gene transfer as a therapeutic, it has been a fascinating opportunity to get to grips with the various processes in the lab; particularly more recently when I have spent time working independently to optimise the process in
various cell subsets.
Not exact matches
These
cells can be classified into three
subsets that each have
various functions.
Smaller
subsets of T
cells are reactive toward
various nonpeptidic ligands associated with nonpolymorphic MHC class - Ib (MHC - Ib) molecules.
«Using different regulators, scientists have been able to induce a
subset of myocardial characteristics in
various experimental models, but never the complete beating phenotype, so there is something special about gata5 that can take a
cell that's not supposed to become a heart
cell to actually become one,» said Stainier.
Because of their ability to differentiate into
various effector T
subsets, Th1, Th2, Th17, and Tregs, CD4 + T
cells are particularly important in the initiation of GVHD in mice and have been considered potential targets for the treatment and prevention of GVHD in the clinic.
These include: a) Global Clusters that consist of a small, tight
subset of genes that are co-expressed under the entire spectrum of experimental conditions; b) Time Series of gene expression profiles during successive days of standard ES
cell differentiation; c) Specific Gene Classes based on hierarchical clustering of transcriptional factors and ESTs; d) Expression Waves of genes with characteristic expression profiles during ES
cell differentiation, juxtaposed to waves of genes that behave in the exact opposite way; e) Pathway Animations that illustrate dynamic changes in the components of individual KEGG signaling and metabolic pathways viewed in time - related manner; and, f) Search Engines to display the expression pattern of any transcript, or groups of transcripts, during the course of ES
cell differentiation, or to query the association of candidate genes with
various FunGenES database clusters.