Sentences with phrase «various types of mutation»

This study leverages deCODE's unique genetics resources in Iceland to build upon earlier results linking parental age and sex to variability in recombination and various types of mutation.

Here, we employed cDNA amplicon sequencing using a long - read portable sequencer, MinION, to characterize various types of mutations in cancer - related genes, namely, EGFR, KRAS, NRAS and NF1.

Not exact matches

This analysis discovered an average of 97 structural rearrangements of the genome per tumor, and some 9,653 mutations of various types in 5,712 genes.

Moreover, the regional susceptibility and tolerance to a particular mutation type is a mixture of various genomic and epigenomic features and selective pressures [64].

Moreover; in addition to the various mutations that have been highlighted and interact in key component of signaling cascades, different types of RNAs have been shown to be involved in melanoma pathogenesis such as: miRNAs and lncRNAs [48, 49].

Dr. Nobrega has modeled the impact of mutations implicated in various human diseases, such as congenital heart defects, heart failure, cancer, type 2 diabetes, obesity, and asthma.

Researchers at Karolinska Institutet, KI, and SciLifeLab have together with colleagues in USA identified mutations in blood, which considerably increases the risk of developing various types of blood cancer, like leukaemia.

The Cancer Gene Census (CGC) database contains 547 such gene across various cancer types.5 Remarkably, few driver genes having specific point mutations appear to be sufficient to rewire signalling networks in cancer, 1 which at the same time shows that — at least from the mutational side — cancer does not consist of an «infinite» number of different diseases, and in many cases treatment options targeted against driver genes might be transferred from one case to the next.

The scientists are also continuing to investigate mutations that occur in the tumors themselves (somatic mutations) and are profiling the susceptibility of specific tumor types to various chemotherapy compounds, which may lead to improved therapy options.

They may have different habits when it comes to screening: Eye exams may not be done beyond the puppy exam or screening for other common traits, like MDR1 (multi-drug reactivity) in various «collie - type» breeds with a high frequency of the mutation.