This activates the mast cells in these organs so that they undergo degranulation, releasing ready - made proteases such as chymase and tryptase, and synthesizing inflammatory mediators (leukotrienes and
vascular endothelial cell growth factor [VEGF]-RRB-.
Not exact matches
So Daniel Anderson at the Massachusetts Institute of Technology exposed human bone marrow stem
cells to biodegradable nanoparticles carrying the human gene for
vascular endothelial growth factor (VEGF), which attracts blood vessels to injury sites.
And they incorporated into the gel a protein known as
vascular endothelial growth factor (VEGF), which encourages the
growth of blood vessels into the transplanted
cells.
A critical discovery in this research was finding that the novel progenitor has a receptor protein on its
cell surface called KDR, or
vascular endothelial growth factor receptor 2, which until now, was thought to be restricted to
endothelial cells that form vessels, the progenitors for
endothelial cells and the progenitors blood
cells.
They focused towards this end on the
vascular growth factor Angiopoietin - 2, which is produced by
endothelial cells and does not just control angiogenesis, but acts as a key responsiveness factor for
endothelial cells.
Due to the lack of oxygen in the cancer
cells, VEGF - A (
Vascular Endothelial Growth Factor) is formed and this promotes the formation of new blood vessels to supply the tumor.
During the creation of new blood vessels, the
vascular endothelial growth factor (VEGF) protein differentiates stem
cells into
vascular endothelial cells and stimulates them to create new blood vessels.
High Serum
Vascular Endothelial Growth Factor (VEGF) Level Is An Adverse Prognostic Factor In High Risk Diffuse Large B -
Cell Lymphoma (DLBCL) Patients Treated with Dose - Dense Chemoimmunotherapy and Systemic CNS Prophylaxis.
↵ 3 The abbreviations used are: HUVEC, human umbilical vein
endothelial cell; DiI - Ac - LDL, 1,1 ′ - dioctadecyl - 3,3,3 ′, 3 ′ - tetramethyl - indocarbocyanine acetylated low - density lipoprotein; FACS, fluorescence - activated
cell sorting; FGFR, fibroblast
growth factor receptor; Flk, fetal liver kinase; ICAM, intercellular adhesion molecule; mAb, monoclonal antibody; PE, phycoerythrin; TNF, tumor necrosis factor; VCAM,
vascular cell adhesion molecule.
High serum
vascular endothelial growth factor level is an adverse prognostic factor for high - risk diffuse large B -
cell lymphoma patients treated with dose - dense chemoimmunotherapy.
Phase II study of cediranib (AZD 2171), an inhibitor of the
vascular endothelial growth factor receptor, for second - line therapy of small
cell lung cancer (NCI # 7097).
Other research has shown that oxygen - deprived
cells in the retina produce a type of protein called
vascular endothelial growth factor (VEGF), which triggers the
growth of new blood vessels in the retina.
Vascular endothelial growth factor (VEGF) expressed by neural progenitor
cells (NPCs)(cyan) stimulates the
growth of blood vessels (red) in the mouse embryonic hindbrain, and provides regulatory factors to promote the self - renewal of neural progenitors.
From these
cell based and clinical studies, we have developed important mechanistic ideas such as activation of protein kinase C, the role of
vascular endothelial growth factor (VEGF) and selective insulin resistance as some of the basic mechanisms for the pathogenesis of diabetic microvascular and cardiovascular diseases which are now widely studied by multiple laboratories.
The researchers found that, when stimulated by insulin, diabetic fibroblasts produced less of the VEGF (
vascular endothelial growth factor) signaling protein, a key player in boosting the
growth of blood vessel
cells, than normal fibroblasts did.
Adults with advanced renal
cell carcinoma after targeted therapy against
vascular endothelial growth factor (VEGF)
«Flavonoids and Vitamin E Reduce the Release of the Angiogenic Peptide
Vascular Endothelial Growth Factor from Human Tumor
Cells».
At the same time, the protein
Vascular Endothelial Growth Factor (VEGF) stimulates blood supply for the damaged tissue, Fibroblast
Growth Factor - 2 (FGF - 2) stimulates the damaged
cells to grow and reproduce themselves, Transforming
Growth Factor - beta (TGF - beta) stimulates cartilage to grow, and Stem
Cell Factor (SCF) stimulates your native inactive stem
cells to become activated and assist in the repair of the damaged tissue.
Researchers report that curcumin reduces all pro-inflammatory molecules in cartilage
cells and in membranes that line the joints, among them tumor necrosis factor — which destroys joint cartilage — and
vascular endothelial growth factor, which promotes excessive
growth of blood vessels in inflamed joints.
One of these
growth factors is
vascular endothelial growth factor - A or VEGF, which acts by binding specific receptors on the hemangiosarcoma
cells.