Sentences with word «vascularization»

The PEC - Direct product candidate delivers stem cell - derived PEC - 01 pancreatic progenitor cells in a device designed to allow direct vascularization of the cells, which is expected to allow for a robust engraftment and cellular performance similar to the anatomy of a normal islet.

Morphological analysis of the tumours revealed significant differences in tumour vascularization in Tie2PEKO mice: MVD was significantly higher in B16 as well as LLC tumours (Fig. 6a, b).

Preventing tumour vascularization is therefore an interesting anti-tumour therapy that has been explored over the last ten years.

Uveitis would cause an accumulation of inflammatory cells in the eye, visible as hypopyon in the anterior chamber (sometimes so severe it obscures the entire chamber with a greenish - yellow haze, obscuring the pupil), occasionally hemorrhage, corneal edema visible as a blue tinge to the surface of the eye, and deep corneal vascularization visible as a red ring around the cornea, at the junction between the cornea and the sclera (white part of the eye).

The three - dimensional vascularization of growth factor - releasing hybrid scaffold of poly (e -LCB- open -RCB-- caprolactone) / collagen fibers and hyaluronic acid hydrogel.

The VC - 01 product is designed to be inserted under the skin followed by vascularization and maturation of the PEC cells to islet - like structures that provide insulin and other regulatory factors in response to blood glucose levels.

(A and B) Confocal images of coronal SVZ sections showing that 22 - month - old mice injected with rGDF11 for 4 weeks have (A) enhanced vascularization as well as (B) increased Sox2 + neural stem cell populations compared with those of control.

Training your aerobic system will increase mitochondria in your muscle cells to generate energy (ATP) and increase capillary vascularization for increased oxygen utilization.

Nevertheless, older individuals had less vascularization and maybe less ability of new neurons to make connections.»

More notably, the human organoids implanted into mice connected to the rodent's circulatory system, making this the first reported vascularization.

They also implanted the newly grown muscle fibers into adult mice and showed that they survive and function for at least three weeks while progressively integrating into the native tissue through vascularization.

Genetic analysis of the same tissue regions revealed higher activation of genes associated with vascularization and altered metabolic states.

When they looked at these tissues in the lab, they saw that it had increased vascularization compared to tissue with low or no epileptic electrical activity.

All this would facilitate the complete vascularization after the bone implant.

«Looking for the origins of schizophrenia: New study on human stem cells, chicken eggs and umbilical cord identifies substances produced by the brain that alter vascularization of patients» nervous system..»

A particular subpopulation of monocytes has angiogenic properties that enables vascularization.

For analysis of plug vascularization, CD34 (Novocastra, #NCL - END, 1:50) immunofluorescence staining was performed.

Pharmacological manipulation of blood and lymphatic vascularization in ex vivo - cultured mouse embryos.

Engineering Angiogenesis 3D printing of tissue constructs with perfusable vascular networks Jordan Miller, Rice University Vascularization of tissue engineered constructs: alternative foreign body responses Michael Sefton, University of Toronto

Zamora DO, Natesan S, Becerra S, et al., Enhanced wound vascularization using a dsASCs seeded FPEG scaffold.

Next, they used a small molecule drug originally developed as a cancer therapy (Ro5 - 3335) to inhibit the activity of RUNX1 in the eye, which led to a 50 % reduction in abnormal vascularization in a rat model of oxygen - induced retinopathy.

Because thermograms — unlike mammograms or breast ultrasound — show vascularization, they are highly useful for breast health screening and monitoring.

Fractures, strains, muscle pulls, edema reduction, and increased vascularization provide benefits to untold conditions patients present each day in your practice.

These results suggest the presence of a developmental regulatory gene important in ocular embryogenesis, with potential implications for other disorders of ocular vascularization.

Dr. Komatsu and his colleagues, Dr. Fangfei Li and Dr. Junko Sawada, used a combination of 3D cell culture and living tissue to show that VEGF promotes vascularization, but the vessel structures formed are chaotic, unstable and non-functional.

The PEC - Direct combination product delivers ViaCyte's PEC - 01 ™ pancreatic progenitor cells in an implantable device designed to allow direct vascularization of the cells.

CSK is characterized by variable degrees of corneal vascularization, pigmentation, granulation tissue and cholesterol deposits (white opacities).

The materials that pharmaceutical companies use to test drugs» effects on cells don't allow for three - dimensional vascularization, a network of capillaries that carry drugs and other materials throughout the body.

Dr. Gollnick's laboratory explores how tumor cells co-opt the host immune system to promote chronic inflammation that leads to increased vascularization, suppression of anti-tumor immunity and increased tumor cell proliferation and migration.

For example, if the process were used to create liver cells for a drug test, the resulting product «would actually have vascularization in it that is modeled on how a liver works.»

The PEC - Direct product candidate delivers stem cell - derived PEC - 01 pancreatic progenitor cells in a device designed to allow direct vascularization of the cells, and is being developed for type 1 diabetes patients that have severe hypoglycemic episodes, extreme glycemic lability, and / or impaired awareness of hypoglycemia.

While cataract is responsible for nearly 20 million of the 45 million blind people in the world, the next major cause is trachoma which blinds 4.9 million individuals, mainly as a result of corneal scarring and vascularization.

Boldrini surmised that reduced cognitive - emotional resilience in old age may be caused by this smaller pool of neural stem cells, the decline in vascularization, and reduced cell - to - cell connectivity within the hippocampus.

«We have engineered a material that can be used to transplant islets and promote vascularization and survival of the islets to enhance their function,» said Andrés García, a Regents» Professor in the Woodruff School of Mechanical Engineering at the Georgia Institute of Technology.

But «vascularization» of cerebral organoids also raises such troubling ethical concerns that, previously, the lab paused its efforts to even try it.

The researchers reported the natural inflammatory response when a foreign substance like a hydrogel is introduced into a system and draws cells that secrete proteins involved in cellular infiltration, scaffold degradation, vascularization and innervation.

«Vascularization is the main limitation to printing large pieces of functional tissue.»

This vascularization is critical because it provides oxygen and nutrients to the follicles and allows hormones produced by the follicles to circulate in the blood stream.