Sentences with phrase «vasculature with»

Bioprinting technique creates thick 3D tissues composed of human stem cells with embedded vasculature with potential for drug testing and regenerative medicine

Employing a combination of cellular, biochemical and genetic experiments, we showed that (i) human and murine pericytes express functional Tie2 receptor, (ii) Tie2 - silenced pericytes have a pro-migratory phenotype, (iii) Tie2 downstream signalling in pericytes involves Calpain, Akt and FOXO3A, (iv) Ng2 - Cre - driven deletion of pericyte - expressed Tie2 delays developmental angiogenesis and vessel maturation, and (v) Tie2 deletion in pericytes results in a pro-angiogenic tumour vasculature with enhanced tumour growth.

Because zebrafish are transparent until their stripes emerge in adulthood, Oehlers could label the bacteria, immune cells, and vasculature with differently colored fluorescent tags and then follow a TB infection over time.

He and his colleagues grew the vasculature with blood - vessel - making (endothelial) cells.

Not exact matches

The researchers look forward to functionalizing nanodrugs with the iron oxide particles to allow mapping of the vasculature and the simultaneous transportation of nanodrugs.

The images enable the researchers to look at blood flow in the breasts, see how the vasculature changes, and how the blood interacts with the tumor.

«We wondered if these neurons were actually altering the way the vasculature forms and behaves,» said TSRI Research Associate Peter Westenskow, co-first author of the new paper with TSRI Research Associate Yoshihiko Usui.

With a view to clinical studies (tests on humans) it is important to note that the effects on the tumor vasculature were even observed at chloroquine concentrations that had little effect on autophagy in the cancer cells.

When replacing the islet vasculature in aged islet grafts with young capillaries, the investigators found that the islets were rejuvenated and glucose homeostasis fully restored.

«The enhancing effect was not seen in a patient tumor sample with a low level of NRP - 1 expression on the vasculature.

Harvard's Jennifer Lewis has 3D printed tissues with vasculature and kept it alive for weeks.

Lewis has previously conducted groundbreaking research in the 3 - D printing of functional materials, including tissue constructs with embedded vasculature, lithium - ion microbatteries, and ultra-lightweight carbon - fiber epoxy materials.

With the ability to become all of the blood cells — including your immune cells, red blood cells, all of your blood system, as well as vasculature — hemangioblasts have been biology's holy grail.

In contrast to more developed vascular plants with roots, stems, leaves, and vasculature, which are necessary for the transport of water and nutrients, it remained unclear in the case of mosses, which have no vasculature, which genes are responsible for the development of stomata.

«We have previously demonstrated that neutrophils form so called neutrophil extracellular traps, NETs, in the vasculature of mice with cancer, which cause impaired blood flow and inflammation in organs such as kidneys.

Therefore, the primary novelty of the discoveries reported here is that programming by prenatal chronic hypoxia of cardiac and vascular dysfunction in adulthood follows the induction of oxidative stress in the fetal heart and vasculature, and that cardiac and endothelial dysfunction in adulthood can both be prevented by maternal treatment with antioxidants during pregnancy.

Indeed, in our tissues we found these type of cells are indeed present, and associated with the vasculature as can be seen in the immunohistochemistry for NG2 and PDGF receptor beta.

Collectively, the experiments identified a more angiogenic and leaky, yet well perfused vasculature in tumours of mice with targeted deletion of Tie2 in pericytes.

Pericyte coverage was determined by measuring the NG2 - positive area associated with the vasculature and correlating it to the vessel area.

The retinal vasculature was stained with Alexa488 - or FITC - conjugated Isolectin B4 (Sigma, 1:100) and NG2 antibody (Millipore, #Ab5320, 1:1,000) overnight at 4 °C.

(c) Representative images of the retinal vasculature stained with isolectin B4 at postnatal day 4 (P4), P6 and in adult WT and Tie2PEKO mice.

Early observations suggesting that the virus might attack cancer in part by damaging blood vessels that feed tumor growth led the SillaJen team to strike up a collaboration with McDonald, an expert in tumor vasculature, to investigate the virus's mechanism of action in animal models.

Our scientists understand that cancer is a complex problem involving factors intrinsic to the tumor that drive its formation, together with tumor - extrinsic mechanisms — notably the vasculature and the immune system — that enable tumor survival.

The NCI's website describes active targeting as «the targeting of nanoparticles to tumor cells, microenvironment or vasculature, as well as directed delivery to intracellular compartments, through nanoparticle surface modification with small molecules, antibodies, affibodies, peptides or aptamers.»

His studies revealed that the blood and lymphatic vasculature, fibroblasts, immune cells and the extracellular matrix associated with tumors are abnormal, collectively creating a hostile tumor microenvironment characterized by hypoxia, low pH and high interstitial fluid pressure.

That's typically associated with autoimmunity, where it creates a vasospasm in the extremities and the vasculature spasm and then, you don't get the blood flow there.

Since cholesterol is the substrate of steroid hormones that decline with age, and is a key compound in membrane integrity of every cell in the body, no wonder seniors benefit from cholesterol, especially when their is no contraindication of a vasculature that is inflamed by oxidative stress.

15 In fact, type 2 diabetes (T2D)-- a condition stemming from broken glucose metabolism and insulin signaling — has been identified as an additional risk factor for developing AD.16, 17 Moreover, the pathological changes that occur in AD in the brain physically resemble those seen in the pancreas and vasculature in T2D.9, 18 Type 2 diabetics who carry ApoE4 alleles are at the greatest risk for AD, with an even more severe risk reserved for those treated with exogenous insulin.19 This suggests that either T2D or related features of the metabolic syndrome bring about AD, or that they are separate consequences of the same underlying cause — and moreover, that insulin is a key factor.

Coconut is very calorie dense and loaded with saturated fat - not good for your vascular tree, though the ketones may be good, overall it is not good for vasculature.

This action creates pressure differences between one area and another, with high pressure pushing old fluid and irritating metabolites into the vasculature and low pressure drawing in new fluid.

Immature worms arriving in the pulmonary vasculature can cause pulmonary arterial, arteriolar, and airway lesions as severe as those seen with death of adult heartworms.

Although heartworm disease in cats can be self - limiting, with a small number of cats able to spontaneously rid themselves of adult worms, migrating larvae damage the lungs and vasculature before clinical signs appear.

Registered Nurse / Instructor — Duties & Responsibilities Provide exceptional patient care and medical team support across multiple medical specialties Skilled in surgical, cardiac, pulmonary, medical, radiology, pediatrics, and emergency room medicine Maintain working knowledge of current medical technology, procedures, and standards of care Create workflows assigning tasks and responsibilities to the nursing team Responsible for scheduling, hiring, payroll, and evaluation of nursing team and support staff Trained in chemical paralytic agents, surgical airways, pericardiocentesis, chest needle compression, and intraosseous access Perform advanced cardiac life support procedures, vasculature access device insertion, and 12 lead EKG's Responsible for intubation, ventilator management, IV and oral medication administration, and monitor line insertion Transport critically ill or injured patients to healthcare facilities and respond to in house codes Maintain professional and courteous communications with patients and family Educate patients and family members in healthy lifestyles and disease management Train nursing students in accepted practices and standards of care Utilize high fidelity mannequins in a variety of situations to develop student critical thinking skills Lead traditional classroom education and scenario debriefs ensuring student comprehension Design and implement engaging curriculum to reach a variety of skill sets and learning styles Offer guidance and support to junior nurses, lab technicians, and medical technologists Oversee confidential patient information, customer service, phones, and other administrative functions as needed Demonstrate ability to remain calm and levelheaded in high pressure situations Perform all duties with positivity, professionalism, and integrity