It might be that only one in 109 (or even 10700) randomly selected sequences would yield a predictable conformation, yet this tiny fraction represents
a vast number of proteins.
Not exact matches
And if you take a single
protein such as t.itin, assembling the components randomly even tens
of thousands
of times per second and discarding each incorrect version would, in that time, completely fill the universe with the debris — a sphere
of 14bn light years diameter, because you have a
number so inconceivably
vast it would have more than 29,000 zeroes (compared to a
number with only 17 zeros for all the seconds so far since the universe began).
As briefly mentioned in
number 6, the
vast majority
of protein powders on the market are actually made by just a handful
of manufacturers who then sell that powder to other companies for additional manipulation and processing.
The nanopores can be filled with specific cytokines, oligonucleotides, large
protein antigens, or any variety
of drugs
of interest to allow a
vast number of possible combinations to treat a range
of infections.
We aim to push its limits on all fronts to establish a technique which combines nanometre 3D resolution with maximum labelling efficiencies, absolute measurements
of protein copy
numbers, precise multi-colour measurements, high - throughput for large scale statistics and novel data analysis approaches, to address the
vast array
of exciting biological questions at the nanoscale, which are becoming accessible only now.
The main molecular alterations are represented by variations in gene expression, usually mild and with consequences for a
vast number of target
protein coding genes.