So she and her colleagues have instead looked for
venom genes in the genome of a close Latrodectus relative, the common house spider, Parasteatoda tepidariorum, which was reported on 31 July in BMC Biology by a team headed by Alistair McGregor of Oxford Brookes University in the United Kingdom.
Not exact matches
These adaptations include the massive and rapid expansion of
gene families that produce
venom toxins, providing the snake with a highly toxic protein mixture required to overcome a variety of different prey and also circumvent any resistance to
venom that may have developed
in such prey.
Armed with the both the king cobra and Burmese python genome the team was able to show that, despite previous hypotheses that
venom genes evolve «early»
in the lineage leading to snakes,
venom gene families do not duplicate early,
in fact the study shows that the rapid and extensive expansion of functionally important
venom toxin families is restricted to the venomous «advanced» snake lineage.
Snake
venoms are complex protein mixtures encoded by several
gene families and these proteins function synergistically to cause rapid paralysis or death
in prey.
Of the
genes undergoing the strongest evolutionary change, many are involved
in body shape and organ development, metabolism,
venom production and the sense of smell (PNAS, DOI: 10.1073 / pnas.1314475110).
Some of these proteins are wasp
venoms, suggesting that
genes from the wasp have been transferred into the virus
in a feat of natural genetic engineering.
But the findings suggest that the wasps don't need mutations
in the
venom toxin
genes to switch from one host to another, or to keep pace with their current hosts.
Consequently, the
gene's protein — which had a benign physiological function elsewhere
in the wasp body — reached a concentration with toxic properties
in the
venom.
One of the orb weaver's silk
genes is even expressed
in the spider's
venom gland.
Instead, Werren likened the functionality of these single - copy
genes to «moonlighting» for extra cash, with the
genes taking on a «night job»
in the
venom gland
in addition to their «day job» elsewhere
in the body.
They just need to be able to co-opt and drop
genes for use
in making
venoms quickly.
What they found surprised them and challenged all of their initial hypotheses: Rattlesnakes have quickly evolved a great variety of differences through the loss of
genes, resulting
in varying
venom gene numbers and types.
Not only does this appear to have led to the unusual
venom differences between species, but the researchers found variety
in the
genes within species as well.
Seeking to understand how the cone snail springs its slow - motion trap, the Utah researchers searched the
gene sequences of all of the proteins expressed
in the
venom gland of Conus geographus.
The insulin
genes were more highly expressed
in the
venom gland than
genes for some of the established
venom toxins.
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