Now, researchers report that they have devised nanoparticles that sop up a variety of common
venom toxins in test tube studies, a key stride in coming up with the first ever broad - spectrum snake antivenom.
Not exact matches
«For the longest time it was thought that only spitting cobras had these defensive
toxins in high amounts
in their
venoms, however we've shown that they are widespread
in cobras.
A newly identified
toxin in the
venom of a tropical centipede helps the arthropod to overpower giant prey
in about 30 seconds.
These adaptations include the massive and rapid expansion of gene families that produce
venom toxins, providing the snake with a highly toxic protein mixture required to overcome a variety of different prey and also circumvent any resistance to
venom that may have developed
in such prey.
Venom from an eastern diamondback rattlesnake
in the Everglades is distinct from the cocktail of
toxins delivered by the same species
in the Florida panhandle area, some 500 miles away.
The diversification of these
toxins correlates directly with their functional importance
in prey capture, for example the most pathogenic king cobra
toxin family have undergone massive expansion, while,
in contrast,
venom proteins with less important functions do not participate
in the evolutionary arms race occurring between snakes and their prey.
Armed with the both the king cobra and Burmese python genome the team was able to show that, despite previous hypotheses that
venom genes evolve «early»
in the lineage leading to snakes,
venom gene families do not duplicate early,
in fact the study shows that the rapid and extensive expansion of functionally important
venom toxin families is restricted to the venomous «advanced» snake lineage.
Ken Shea and colleagues at the University of California, Irvine, used melittin, the
toxin in bee
venom, as the antigen (the substance triggering an immune reaction).
Shea notes that although he and his colleagues have yet to finalize their measurements on how well their nanoparticles bind to various PLA2 molecules, their test - tube results suggest that they could have a similar high affinity for PLA2s as their previous nanoparticles had for melittin, the bee
venom protein that stopped the
toxin in animal studies.
The crustacean
venom also contains a
toxin that is nearly identical to a paralysis - inducing neurotoxin first described
in spiders
in 2010.
According to Drs. Moran and Sunagar, «The «two - speed» mode of evolution of animal
venoms involves an initial period of expansion, resulting
in the rapid diversification of the
venom arsenal, followed by longer periods of purifying selection that preserve the now potent
toxin pharmacopeia.
Claudio Vita and his colleagues at the protein engineering department of CEA, the French nuclear research agency
in Gif - sur - Yvette, are using the
toxins found
in scorpion
venom as a chemical scaffold to build novel proteins for use as drugs (Proceedings of the National Academy of Sciences, vol 92, p 6404).
Yet when Casewell, Fry and colleagues put together an evolutionary family tree for the blennies, the one genus with both fangs and
venom branched off amid four genera that are all fang and no
toxins, Casewell, Fry and colleagues report
in the April 24 Current Biology.
But the findings suggest that the wasps don't need mutations
in the
venom toxin genes to switch from one host to another, or to keep pace with their current hosts.
«These findings raise important questions relating to the processes that other venomous animals may have used to generate their
venom toxins,» wroteNicholas Casewell, senior lecturer and Wellcome Trust research fellow with the Alistair Reid Venom Research Unit at the Liverpool School of Tropical Medicine, in a summary dispatch published alongside the Current Biology p
venom toxins,» wroteNicholas Casewell, senior lecturer and Wellcome Trust research fellow with the Alistair Reid
Venom Research Unit at the Liverpool School of Tropical Medicine, in a summary dispatch published alongside the Current Biology p
Venom Research Unit at the Liverpool School of Tropical Medicine,
in a summary dispatch published alongside the Current Biology paper.
Harvesting
venom is easier when working with large spiders, which secrete the
toxin — then collected noninvasively with a pipette —
in sufficient amounts for researchers to analyze and test.
A new study by Rice University biophysicists offers the most comprehensive picture yet of the molecular - level action of melittin, the principal
toxin in bee
venom.
«Bee
venom: Biophysicists zoom
in on pore - forming
toxin.»
The insulin genes were more highly expressed
in the
venom gland than genes for some of the established
venom toxins.