Sentences with phrase «ventral tegmental area»

In the brain, they are located in the hypothalamic ventromedial nucleus and arcuate nucleus, as well as in ventral tegmental area dopamine neurons projecting to the nucleus accumbens.

In the brain, the ghrelin receptor is located in the the hypothalamic ventromedial nucleus and arcuate nucleus, as well as in ventral tegmental area dopamine neurons projecting to the nucleus accumbens.

People who showed more replay of high - reward memories showed better retention of these events during the post-scan test, as well as increased interactions between the hippocampus, a structure deep in the brain heavily involved in memory, and an area called the substantia nigra / ventral tegmental area complex, which is involved in reward processing, suggesting that reward played a role in stimulating the hippocampus after learning.

This aberrant 2 - AG signaling reduces inhibitory GABAergic signaling at ventral tegmental area dopaminergic synapses, resulting in enhanced dopamine cell excitability and excessive dopaminergic responses to nicotine.

Collectively, these data reveal the contribution of impaired ventral tegmental area function to social behaviors and identify mGluR1 modulation during postnatal development as a potential treatment strategy.

Your brain's pleasure center (aka ventral tegmental area, or VTA, and nucleus accumbens, or NA) is the root of all behavior, driven by chemical messengers that are intimately tied into the energy processes I have outlined above.

Local infusion of low, but not high, doses of alcohol into the anterior ventral tegmental area causes release of accumbal dopamine

This network of neurons, a circuit running through the ventral tegmental area (VTA), the nucleus accumbens and the prefrontal cortex, is normally activated when an animal does things — such as eating or sex — that help it to survive.

Looking inside the brains of animals exposed to chronic social defeat stress, the scientists observed hyperactive firing of neurons in the ventral tegmental area (VTA), a critical part of a reward circuit.

The ventral tegmental area (VTA) and a related adjacent area called the nucleus accumbens (NAc) were crucial to the dopamine system.

To regulate mood, the prefrontal cortex acts as a pacemaker to coordinate the actions of the amygdala, which governs stress responses, and the ventral tegmental area, which plays a role in the brain's reward circuitry.

In experiments reported online in the journal Current Biology, researchers from Massachusetts General Hospital (MGH) and the University of Leuven in Belgium confirm for the first time that stimulation of the ventral tegmental area (VTA)-- a group of neurons at the base of the midbrain — can change behavior through activation of the brain's reward system.

Then the researchers used their engineered mouse model to confirm the precise location, the ventral tegmental area (VTA), part of the midbrain that plays a role in the reward system and addiction.

Mice in booze camp In the new study, performed on adolescent male mice, ethanol alcohol exposure seemed to enhance synaptic plasticity in the ventral tegmental area (VTA), a part of the brain that plays a critical role in the reward pathway.

Drugs of abuse impact the ventral tegmental area (VTA) of the brain, which is rich in dopamine neurons.

Glutamate indirectly activates the substantia nigra and ventral tegmental area, which contain cells whose axons release dopamine in the hippocampus.

Anikeeva and her colleagues injected custom - made, 20 - nanometer iron oxide particles into a region of the rodents» brains called the ventral tegmental area (VTA), a well - studied deep brain structure essential to the experience of reward, which plays a central role in disorders such as addiction and depression in people.

Led by Amy Lasek, assistant professor of psychiatry in the UIC College of Medicine, researchers found that neurons in a region of the brain called the ventral tegmental area, or VTA (also known as the «reward center»), fired most rapidly in response to alcohol when their estrogen levels were high.

The U.C. San Francisco team had previously shown that upping levels of GDNF into a part of the brain associated with drug addiction (the ventral tegmental area) dramatically curtailed the animals» habits.

The researchers focused on one of the mPOA's major connections, through which it sends neural signals to another brain structure called the ventral tegmental area (VTA)-- known to be a powerful contributor in motivating behavior and the release of the neurotransmitter dopamine.

Between - group analysis of phase 2 demonstrated a significant activation cluster in the ipsilateral posterior insula (pIns) in group P. Using the pIns as a seed region the PPI analysis yielded a significant enhanced coupling to the midbrain (periaqueductal grey / ventral tegmental area) after analgesia onset in group A only.

The blunted dopamine signaling to ethanol arose due to changes in the circuitry in the ventral tegmental area, the heart of the brain's reward system.

Neuroscientists know that a particular brain structure, the ventral tegmental area, or VTA, is the origin of numerous dopamine - secreting nerve fibers that run in discrete tracts to many different parts of the brain.

This rise in BDNF concentration, the scientists say, results from increased activity of neurons in the ventral tegmental area, a midbrain structure that sends signals to the nucleus accumbens via the chemical messenger dopamine.

12 Can't Get Enough of Your Love: Dopamine is produced in the ventral tegmental area of the brain, the same region affected by addictive drugs like cocaine.

«Resilient mice overcome this change by counteradapting their gene expression [the suite of genes that act on the nucleus accumbens that are either turned on or off] to clamp down the levels of activity in the ventral tegmental area.»

Previous research had identified that the prelimbic cortex, part of the prefrontal cortex, has three «downstream» channels into the nucleus accumbens, the amygdala, and the ventral tegmental area.

More specifically, in a 2012 review of the love research literature Lisa Diamond and Janna Dickenson, psychologists at the University of Utah, found romantic love is most consistently associated with activity in two brain regions — the ventral tegmental area (VTA) and the caudate nucleus.

Until now, the area of the brain where these neurons are found, called the ventral tegmental area (VTA), had only been associated with the reward system — not stress from withdrawal.

An ancient structure called the ventral tegmental area (VTA) controls our ability to use past experience as a predictor of future reward.

Su - Rong Yang, Zhen - Zhen Hu, Yan - Jia Luo, Ya - Nan Zhao, Huan - Xin Sun, Zhi - Li Huang and colleagues show that the tail of the ventral tegmental area of the midbrain, which is primarily composed of GABAergic neurons, regulates non-rapid eye movement sleep by modulating dopaminergic systems.

Through the combined use of in vivo microdialysis and behavioral and neuropharmacological techniques, his early work characterized the role of serotonin and its signaling via serotonin - 1B (5 - HT1B) receptors in the ventral tegmental area, nucleus accumbens, and ventral pallidum in the rewarding actions of cocaine and ethanol.

They become like a self - stimulating rat, pressing a bar to deliver electricity to its brain's ventral tegmental area, which stimulates its nucleus accumbens to release dopamine, which feels... ever so good.

Upon intake of alcohol, the absence of the RASGRF - 2 impaired the activity of dopamine - releasing neurons in a region of the brain called the ventral tegmental area (VTA) and prevented the brain from releasing dopamine, and hence any sense of reward.

They focused on one of its major pathways, the ventral tegmental area (VTA), which the mPOA use to transmit messages to other parts of the brain.

Gil, M. Nguyen, N.T., McDonald, M., and Albers, H.E. Social reward: Interactions with social status, social communication, aggression, and associated neural activation in the ventral tegmental area.

Here we used shRNA to model Shank3 insufficiency in the ventral tegmental area of mice.

Previous research in the laboratory of Daniel McGehee, PhD, neuroscientist and associate professor in the Department of Anesthesia & Critical Care at the Medical Center, discovered that nicotine could promote plasticity in a region of the brain called the ventral tegmental area (VTA).

This has implications for how and where specialization of dopami - nergic circuits arises, and suggests that many important computations are performed locally within the ventral tegmental area and the substantia nigra pars compacta.

(B) Confocal images of ventral tegmental area (VTA) brain slices from dopamine transporter Cre (Slc6a3Cre) mice transduced with Cre - dependent viruses expressing either PLE and mCherry (left) or EGFP (right) on opposite sides of the VTA.

Dopamine (DA) neurons are found in the ventral tegmental area (VTA) and the substantia nigra pars compacta (SNc).

When we do something pleasurable, a bundle of neurons called the ventral tegmental area uses the neurotransmitter dopamine to signal to a part of the brain called the nucleus accumbens.

The team's scans revealed a tiny area of the brain called the ventral tegmental area (or VTA for short) lighting up when the study's participants were shown a photo of their beloved.

During an MRI, the brain of a person who's in love will be activated in a region called the ventral tegmental area - a key part of the brain's pleasure and reward circuit.

Mobbs saw that subjects» brains became highly activated for all the cartoons, but one subset of structures responded solely for the funny ones — namely, the ventral tegmental area, the nucleus accumbens, and the amygdala.

In the earlier stages of love, other brain areas such as the caudate nucleus and the ventral tegmental areas become active.