«In two studies of breast - fed infants involving more than 3,000 children in Britain and New Zealand, breastfeeding was found to raise intelligence an average of nearly 7 IQ points if the children had a particular
version of a gene called FADS2.
A version of the gene called APOE3 has no effect on Alzheimer's risk, whereas the APOE2 version protects against the disease.
At the time, scientists studying Icelandic horses known for a special gait discovered that they, as well as American Standardbred horses used in harness racing, share a somewhat shortened
version of a gene called DMRT3.
To devise a potential new therapy, the investigators engineered a population of neural stem cells to express a potent
version of a gene called TRAIL, which codes for a molecule that activates cell - death - inducing receptors found only on the surface of cancer cells.
The study team injected patients with a vector, a genetically engineered adeno - associated virus, which carried a normal
version of a gene called RPE65 that is mutated in one form of LCA.
And he's focusing on faulty (mutated)
versions of a gene called JAK2.
Dogs with DM have two copies of a particular
version of a gene called SOD1.
Not exact matches
The less adept mice, Rubin's team found, carry extra copies
of a previously known human
gene called DYRK; a mutated
version of an almost identical
gene in fruit flies,
called minibrain, causes neurological defects.
Particular
versions of one such
gene,
called CRH, were more common in people who had been abused as children but didn't suffer from depression as adults, for instance.
University
of Washington pathology professor George Martin and his colleagues at the Osaka University Medical School in Japan studied 347 Japanese, each with one
of three
versions of the Werner
gene: the so -
called cysteine - cysteine (CC), cysteine - arginine (CR), and arginine - arginine (RR) genotypes.
The two closely related regulatory
genes are active in the normal development
of mammals and govern how RNAs produced from the
genes are joined to make final
versions of the encoded protein, a process
called alternative splicing.
In the second stage
of the study, the researchers used another
version of the
gene - probe technology,
called «quantitative PCR,» which yielded the vaginal concentrations
of each
of the 20 species in every sample, and linked it to HIV risk.
The researchers first used yeast to quickly and cheaply screen 169,000 interactions between yeast
versions of human tumor - suppressor
genes and
genes that can be inhibited with drugs, sometimes
called «druggable» targets.
Different
versions of genes can vary at single points in their sequence, and these variations are
called SNPs.
Athletes who excel in endurance sports are more likely to have another
version of the
gene — this one
called the X variant — that does not produce actinin.
Because the leg fan reminded the researchers
of a Japanese fan, they decided to
call the newer
gene geisha and its ancestral
version mother
of geisha.
People with the so -
called GG
version of the oxytocin receptor
gene were judged to be kinder than those with GA or AA
versions.
In 2006, researchers discovered the genetic defect behind FOP: A mutated
version of the
gene ACVR1, which in patients produces an overactive form
of a cell surface protein
called a transmembrane receptor.
Then for HARE5, the most active enhancer in an area
of the brain
called the cortex, they made minigenes containing either the chimp or human
version of the enhancer linked to a «reporter»
gene that caused the developing mouse embryo to turn blue wherever the enhancer turned the
gene on.
Hutchinson - Gilford progeria is caused by a spontaneous mutation during conception in a
gene called LMNA, which encodes a protein
called prelamin A. Progeria patients experience a buildup
of an abnormal
version of prelamin A in their cells that, among other changes, distorts the nucleus and alters
gene expression.
In oncology terms, this double - hit status is
called «loss
of heterozygosity,» or LOH, to signify that both
versions (one from mom, one from dad)
of the normal BRCA
gene have been hobbled.
Horses homozygous (having two copies)
of one
version (allele)
of the
gene — the so -
called CC horses — are sprinters, she says.
The process
of figuring out which
of these genetic differences lie on each chromosome is
called haplotyping, and it's an important step toward identifying which
version of a
gene may cause disease.
Genetic analysis revealed that eight people who got relief from the placebo had a particular
version of a
gene that regulates serotonin production
called the tryptophan hydroxylase - 2 promoter (TPH2), the researchers report tomorrow in the Journal
of Neuroscience.
Then they studied how two
versions of this
gene,
called C and G, affected IQ in 1000 children who grew up in New Zealand and 2200 children who grew up in Britain.
In a study published in Cell Stem Cell, the researchers used a modified
version of CRISPR
called CRISPR interference (CRISPRi) to inactivate
genes in iPSCs and heart cells created from iPSCs.
CRISPRi, first reported in 2013, relies on a deactivated
version of the Cas9 protein, which — together with an inhibitor protein
called KRAB — sits on a target
gene.
In mouse models in which the endogenous Smn1
gene has been knocked out and human
versions of SMN2 have been swapped in, the Isis therapy — a so -
called «antisense oligonucleotide» — delivered to the mouse central nervous system (CNS) increased the expression
of full - length SMN protein in motor neurons, improved muscle strength in behavioral tests and extended the rodents» median lifespan from 16 days to 26 days3.
The new system,
called Casilio, combines an altered
version of CRISPR (CRISPR - dCas9) with the Pumilio RNA - binding protein system to enable much broader
gene manipulation power.
The shorter
version of the
gene, which is
called GRIK4, makes a more stable receptor for glutamate, a key brain - signaling molecule.
However, if you're a woman who has this
gene mutation, you're not going to be able to absorb folic acid properly and need to be taking the real
version of folic acid
called folate.
Future treatments may involve the administration
of a miniature
version of the affected
gene,
called a microgene, into the body to protect muscles, but is not yet available.
I tend to be suspect
of anything that seems to capture the adoration and hearts
of the general public (see American Idol, the American
version of The Office, Titanic, the Snuggle, and 401K Retirement Plans) but at the same time, I'm just as suspect
of so -
called expert advice (see
Gene Shalit, CNBC, and the Catholic Church).