Sentences with phrase «version of the human gene»

Not exact matches

Traces of common origins were everywhere: Humans even possessed a broken version of the gene that lizards and birds use to produce eggs.

Capra and others have evidence that Neandertal versions of genes make humans more prone to some diseases (SN: 3/5/16, p. 18).

But when Cherr and his colleagues finally got around recently to checking out the protein in humans, they got a big surprise: About a quarter of men don't make it properly because they have a mutant version of the relevant gene.

The less adept mice, Rubin's team found, carry extra copies of a previously known human gene called DYRK; a mutated version of an almost identical gene in fruit flies, called minibrain, causes neurological defects.

When the researchers compared the mRNA to a library of DNA sequences taken from the dendrites of neurons by James Eberwine of the University of Pennsylvania Medical Center, they found that it came from a single gene on chromosome X — the human version of which, when mutated, leads to fragile - X syndrome.

O'Rahilly knew that the absence of leptin did not prove the children harbored a human version of the mouse fat gene, it merely posed the possibility.

The team sequenced the gene that codes for the NaV1.7 channel in mole rats, and compared it with SCN9A — a key gene in the human version of the channel.

When we took the mouse version of this gene — the same gene we find in the human — and put it in the fly and tweaked it, we induced fly eye tissue.

Shatz got a hint when she looked up ailments associated with mutations in genes coding for the human version of MHCI.

First they smuggled the gene aboard a disabled version of the adeno - associated virus, which thrives in the guts of rats and humans.

All land vertebrates carry a version of the FOXP2 gene, so some of the Oxford researchers then teamed up with colleagues from the Max Planck Institute for Evolutionary Anthropology in Germany to analyze what is unique about the variant in humans and to track how the gene had evolved in our ancestors.

Humans have evolved several versions of the APOE gene, one of which — APOE4 — makes a person more likely to develop Alzheimer's.

In 2002 a student in Christiano's lab was studying the Human Genome Project database and noticed an unnamed region where Christiano had predicted the human version of the lanceolate gene would reHuman Genome Project database and noticed an unnamed region where Christiano had predicted the human version of the lanceolate gene would rehuman version of the lanceolate gene would reside.

The researchers first used yeast to quickly and cheaply screen 169,000 interactions between yeast versions of human tumor - suppressor genes and genes that can be inhibited with drugs, sometimes called «druggable» targets.

The results suggest the human version of the FOXP2 gene may enable a quick switch to repetitive learning — an ability that could have helped infants 200,000 years ago better communicate with their parents.

To try to determine how those changes influenced the gene's function, that group put the human version of the gene in mice.

When the scientists looked for the human version of the newly identified fly marker for sleep deprivation, they found ITGA5 and realized it hadn't been among the human immune genes they screened at the start of the study.

To prevent this decline in Area X, White's research team used methods similar to human gene therapy to insert a version of FoxP2 in male zebra finches.

In both humans and birds, cells process this gene in a way that produces both a full - length protein and a shorter version of the protein.

Auriel Willette, an assistant professor of food science and human nutrition; and Joseph Webb, a graduate research assistant, found on average that Caucasians with one bad version of the gene — guanosine triphosphate cyclohydrolase - 1 or GCH1 — developed Parkinson's symptoms five years earlier, and had a 23 percent increased risk for the disease.

When transplanted into human cells in the laboratory, the mammoth TRPV3 gene produced a protein that is less responsive to heat than an ancestral elephant version of the gene.

Scientists then looked at the human version of the gene, and found that the gene was mutated in people suffering from Native American myopathy.

On the other hand, in no case did Africans and Neanderthals share similar versions of a gene, to the exclusion of other humans.

They also say they are concerned about the antibiotic resistance marker gene that the wheat contains, and assert that the researchers «are openly releasing a synthetic version of a compound that... has had no long - term health safety tests whatsoever for human consumption, or for its impacts on non-target species.»

«When we say the foraging gene is the same, what we're saying is that when you look at the DNA sequences of the human and the fly there is a lot of similarity, enough that you can see it's the fly version of the gene that the human has,» says Sokolowski.

Humans evolved Coordinator mutations that are good at turning on human versions of genes, but not so great at turning on chimp genes.

Earlier versions of these «base editors,» which target typos related to the other half of disease - causing genetic spelling errors, have already been used to alter genes in plants, fish, mice and even human embryos.

Then for HARE5, the most active enhancer in an area of the brain called the cortex, they made minigenes containing either the chimp or human version of the enhancer linked to a «reporter» gene that caused the developing mouse embryo to turn blue wherever the enhancer turned the gene on.

The human version of the FOXP2 (short for fork - head box P2) differs from that of the chimp (the closest living relative of humans) in two places along the genetic code, causing differences in two amino acids in the protein coded by the gene.

Then they slipped a human version of each gene into yeast cells whose own copy of the gene had been turned down, turned off, or removed.

It also contains some of the most variable human genes: hundreds of versions — or alleles — exist of each gene in the population, allowing our bodies to react to a huge number of disease - causing agents and adapt to new ones.

And researchers at Stanford University School of Medicine report in Genome Research that they linked the evolution of a gene in the old platypus to a mutated version in humans responsible for moving the testes outside of the body and into an external pouch, or scrotum.

Neves and Chess hypothesize that a different version of the gene may affect humans similarly.

Taking advantage of these «simplified» versions of melanoma, the researchers identified a dozen of new genes that are likely to play key roles in the initiation and / or progression of human melanoma.

In humans, Galatzer - Levy found that different versions of the fkbp5 gene were able to predict specific differences in extinction learning related to PTSD symptoms such as reliving or re-experiencing the traumatic event; avoiding reminders of the event; and, in particular, hyperarousal, or the inability to sleep or concentrate.

So far, scientists have found that different populations of living humans have inherited the Neandertal version of genes that cause diabetes, lupus, and Crohn's disease; alter immune function; and affect the function of the protein keratin in skin, nails, and hair.

«Our conclusions make sense, especially in light of the work of other researchers who have shown that the human version of the FDNC5 gene has a deleterious mutation at the beginning,» Erickson said.

Might Neanderthals have benefited from gaining modern human DNA, for example, in their version of the FOXP2 gene?

These mice have their hemoglobin genes removed and replaced with the mutated human version, saddling them with many of the same problems as human sufferers, including immature, short - lived, and sickle - shaped red blood cells; anemia; reduced blood flow; and an enlarged spleen.

Dr. Zhu began his investigation by studying a mouse that lacked Arid1a, the mouse version of a gene associated with some human cancers.

This version covers 15,156 genes (approximately 75 % of human protein - coding genes) and includes protein expression profiles based on 18,707 antibodies.

«To hone in on functional conservation, we focused on Cindr, the fly's version of the human NS gene, CD2AP.

Dr. Verma and his Salk colleagues pioneered the use of a stripped - down version of the human immunodeficiency virus (HIV, the causative agent of AIDS) to carry genes into defective cells.

To wit, years after the Jans» report on atonal, the role of the gene's mammalian versions in human sight and hearing came to light.

A collaborative group of international researchers has now studied the human version of the ASIC1a gene, ACCN2, and report their findings in the current issue of Biological Psychiatry.

In mouse models in which the endogenous Smn1 gene has been knocked out and human versions of SMN2 have been swapped in, the Isis therapy — a so - called «antisense oligonucleotide» — delivered to the mouse central nervous system (CNS) increased the expression of full - length SMN protein in motor neurons, improved muscle strength in behavioral tests and extended the rodents» median lifespan from 16 days to 26 days3.

But, after researchers at Oregon Health and Science University managed to change the mutated version of the MYBPC3 gene to the unmutated version in a viable human embryo last month, the predictable bioethical debate was reignited, and terms such as «Designer Babies» got thrown around a lot.

Only a year after he produced the first iPS cells from adult mouse skin cells, Yamanaka generated iPS cells from adult human skin cells, employing human versions of the same four genes that he had used in the mouse work.

To repair the problem, the research team «broke» the mutated version of the MYPBC3 gene inside human embryos, using technology that allows scientists to snip a specific target sequence on a mutant gene.

Neu5Gc is the glycolyl capped sialic acid that is found on the cell surfaces of all mammals except humans, who lost the gene for the enzyme to oxidize the acetyl version.