Having the right alleles (different
versions of a given gene, as when the A1 allele of the D2 dopamine receptor produces 30 percent fewer receptors than the more common A2 allele) available somewhere in the population can make one species do better than another when the climate perturbs things.
Not exact matches
Normally, to achieve such a rapid evolutionary shift, a species needs to start with an alternative
version of a
gene already in circulation,
giving natural selection more to work with, but in deer mice the new
version of Agouti spread rapidly from a standing start.
So, for example, just to say for the sake
of argument, that there's a
gene that influences the width
of the birth canal, and lets say that some
versions of the
gene leave women more likely to have trouble
giving birth, so that their children have loss
of oxygen and that could lead to changes in the brain that lead to lower intelligence scores.
Sabeti's technique identifies
versions of genes that have been created by random mutation and then retained — because they
give their owners some natural advantage over individuals who do not have the mutation.
Stem cells were harvested from Nina's bone marrow and
given a working
version of the ADA
gene, before being injected back in.
Immune cells from 4 - year - old Ashanti DeSilva are
given working
versions of the ADA
gene to treat severe combined immunodeficiency disorder (SCID).
For
gene hunters, it's relatively straightforward to determine where a
version of a particular
gene lies on a
given chromosome.
Gene therapy treats genetic diseases by giving patients a healthy version of a defective g
Gene therapy treats genetic diseases by
giving patients a healthy
version of a defective
genegene.
The founders
of any
given breed will have only a subset
of all the
versions of genes — good and bad — present in the canine species.