Sentences with phrase «vertebrate genome»

Studies The Puppy Up Foundation helped fund with The Broad Institute: Title of Study: Osteosarcoma Grant Awarded: $ 20,000 Principal Investigator: Kerstin Lindblad - Toh Scientific Director of Vertebrate Genome Biology at the Broad Institute Broad Institute of MIT and Harvard Title of Study: Mast Cell Tumors Grant Awarded: $ 20,000 Principal Investigator: Kerstin Lindblad - Toh Scientific Director of Vertebrate Genome Biology at the Broad Institute Broad Institute of MIT and Harvard

On September 1st, 2015 we received a curt response from Michele Koltookian, Sample Coordinator, Vertebrate Genome Biology, The Broad Institute of Harvard and MIT.

They report that the genes encoding the different subunits of PDE6 in cones and rods arose from ancestral genes that duplicated in the early vertebrate genome doublings, and further expanded in teleosts due to the extra genome duplication that took place in this lineage.

«Our study reveals a spectrum of methods that nature uses to allow organisms to adapt to different environments,» said co-senior author Kerstin Lindblad - Toh, Co-Director of SciLifeLab, scientific director of vertebrate genome biology at the Broad Institute and professor in comparative genomics at Uppsala University «These mechanisms are likely also at work in humans and other vertebrates, and by focusing on the remarkably diverse cichlid fishes, we were able to study this process on a broad scale for the first time.»

Plenary Address: Kerstin Lindblad - Tho Professor in Comparative Genomics, Uppsala University, Sweden; Scientific Director of Vertebrate Genome Biology, Broad Institute, USA.

«It was exciting to see that half of the domestication signals in the genome point to genes that have to do with brain development and function», says professor Kerstin Lindblad - Toh, senior author and director of SciLifeLab Uppsala, and scientific director of vertebrate genome biology at the Broad Institute.

The Vertebrate Genome Annotation (Vega) database is a community resource for browsing manual annotation from a variety of vertebrate genomes of finished sequence (http://vega.sanger.ac.uk).

Toward this end, we focused on a medically relevant 2.6 - Mb region of the human chromosome Xp11.4 between markers DXS9851 and DXS9751 and identified 16 transcription units according to the Vertebrate Genome Annotation (Vega) rules.

The Vertebrate Genome Annotation (Vega) database (http://vega.sanger.ac.uk) has been designed to be a community resource for browsing manual annotation of finished sequences from a variety of vertebrate genomes.

The elephant shark has the smallest genome among cartilaginous fishes, and has been shown to be the slowest evolving vertebrate genome, according to a new study in the journal Nature.

«Our study reveals a spectrum of methods that nature uses to allow organisms to adapt to different environments,» said senior author Kerstin Lindblad - Toh, Scientific Director of Vertebrate Genome Biology at the Broad Institute: «These mechanisms are likely to be also at work in humans and other vertebrates, and by focusing on the remarkably diverse cichlid fishes, we were able to study this process on a broad scale for the first time.»

ENSEMBL makes available substantial and diverse transcript information, including the CCDS [13, 41], Human and Vertebrate Analysis and Annotation (HAVANA)[42], Vertebrate Genome Annotation (Vega)[43], ENCODE data [12] and the GENCODE gene and transcript sets [15].

The more we understand about how natural variation in the vertebrate genome shapes the development and function of the brain, the better insight we can have into how behavioral patterns evolve, and how disruption to neurogenetic pathways can lead to brain and behavioral dysfunction.

«It's by far the oldest vertebrate genome we have so far,» says Johannes Krause of the University of Tübingen, Germany, who was not involved in the study.

Unlike the previous studies that focused on certain species or a particular RNA virus, Skalka went broad: She and her colleagues surveyed every vertebrate genome available, 48 in all, and looked for hints of 5666 RNA viral sequences from 38 known families and nine genera that were unclassified.

Fugu — the poisonous puffer fish sought after by brave suchi - eaters — has the smallest known vertebrate genome.

The performance of our workflow was assessed on vertebrate genome assemblies of various qualities (platypus, pig, horse, dog, mouse and human).

«Vertebrate genomes are typically on the larger side, so it takes a lot of computational power to assemble them,» says Card.

Yet trying to understand the genetic explanations of such questions is surprisingly difficult considering most vertebrate genomes, including our own, are made up of literally billions of DNA bases that can determine how an organism looks and functions,» says Castoe.

A new look at a virtual zoo - full of animals, from hummingbirds to bats to elephants, suggests that many vertebrate genomes have the same accordion - like properties.

But now that three vertebrate genomes have been sequenced — human, mouse, and pufferfish — geneticists are re-thinking their appraisal.

According to recent estimates, while over 30 % of vertebrate genomes is transcribed (2), only 1 % consists of coding genes, suggesting that the rest must be various types of non-coding RNA genes.

Indeed, the BDV discussed earlier inserted some of its sequences into vertebrate genomes approximately 40 million years ago [56], and presence of these sequences correlates with disease resistance to BDV.

Not exact matches

As vertebrates evolved, the entire genome was duplicated not once but twice.

By comparing the genomes of 203 vertebrates, they first traced the origin of KZFPs back to a common ancestor of tetrapods (four - legged animals) and coelacanth, a fish that evolved over 400 million years ago.

Once thought rare in humans and other vertebrates, RNA editing is now recognized as widespread in the human genome.

Before the consortium came together, he had participated in sequencing the genomes of two vocal learners, a songbird and a parrot, but he knew he couldn't do all of the additional sequencing and analysis work that would be required to identify genes related to vocal learning — not by himself, at least — so he teamed up with Genome 10K, a project aiming to collect genomes for 10,000 vertebrate species.

Hughes's winning research proposed using microarray techniques to compare the genomes of a variety of vertebrate animals to test for common regulatory elements that determine gene expression.

Genome sequencing confirms that myxozoans, a diverse group of microscopic parasites that infect invertebrate and vertebrate hosts, are actually are «highly reduced» cnidarians — the phylum that includes jellyfish, corals and sea anemones.

For most vertebrates it's not immediately apparent why genome deletions and add - ons typically go hand - in - hand.

While that is close to true for coelacanths, other famous «living fossils,» which have the slowest molecular evolutionary rate among vertebrates, the Lingula genome has been evolving rapidly, despite the lack of changes in appearance.

TheCiona genome contains ∼ 16,000 protein - coding genes, similar to the number in other invertebrates, but only half that found in vertebrates.

To resurrect a working vertebrate transposon, molecular geneticist Perry Hackett at the University of Minnesota, Twin Cities, and his colleagues Zoltan Ivics, Zsuzsanna Izsvak, and Ronald Plasterk turned to the salmon genome, where transposons had been active more recently in evolutionary time.

To illuminate the origins of chordate and vertebrates, we generated a draft of the protein - coding portion of the genome of the most studied ascidian, Ciona intestinalis.

In 2009, he and two others started the Genome 10K project, a call for the sequencing of 10,000 vertebrates.

In existing vertebrates, genome size correlates very closely with bone cell size, so Organ used the size of dinosaur bone cells to predict how much genetic material the extinct animals possessed.

«This is the first time the complete genetic code — the genome — of any vertebrate species from Panama has been sequenced and analyzed,» said Oris Sanjur, co-author and Associate Director for Science Administration at STRI.

Professor Griffin explained: «Bird genomes are distinctive in that they have more tiny microchromosomes than any other vertebrate group.

To study evolution across a major vertebrate class, dissect the genomics of complex traits, and resolve a centuries - old debate on the avian species tree, we formed a consortium focused on the sequencing and analyses of at least one genome per avian order.

The international group of researchers analyzed the genomes of 48 avian species that represent the evolutionary history of modern birds and compared them to many other vertebrates to find DNA sequences specific to avians.

Tohoku University researchers and their international collaborators compared the genomes of 48 avian species with other vertebrates to identify genetic sequences specific only to birds.

After removal of similar viral genomes, bootscan plots of the whole genome and individual genes from a subset representing human / simian adenoviruses in species A — G and all non-primate vertebrate adenoviruses were generated.

Kerstin Lindblad - Toh, professor in comparative genomics and director at SciLifeLab in Uppsala, has led the studies where an international consortium of researchers mapped the coelacanth genome and compared it with the DNA of terrestrial vertebrates.

In an effort to understand the molecular basis of adaptation in vertebrates, researchers sequenced the genomes and transcriptomes of five species of the African cichlid fish.

If the genome projects verify the underlying octoploid nature of the human and mouse genomes, then the basic vertebrate gene number may be similar to that of the fly and worm, about 12,000 to 14,000 genes.

Sequencing the zebrafish genome provided evidence of more than 26,000 protein - coding genes, the largest set of any vertebrate sequenced so far.

Among vertebrates, the fish model displays easy high density breeding (short generation time), favourable biological peculiarities (accessibility and transparency of the eggs, genome sequenced for both species used on the platform), original technological approaches (confocal and two - photon microscopy), as well as a wide accessibility to fully transparent larvae usable up to 5 days after fertilization.

The phylogenetic position of the cephalochordate amphioxus, together with its relatively simple and evolutionarily conserved morphology and genome structure, has led to its use as a model for studies of animal evolution, with a special focus on the origin of deuterostomes, chordates, and vertebrates.

The chimp genome was published in 2005,2 when I was a postdoc at the University of California, Santa Cruz, and those of 12 other vertebrates followed shortly thereafter.

In an effort to understand the molecular basis of adaptation in vertebrates, researchers sequenced the genomes and transcriptomes of five species of African cichlid fishes.