Those experiments, led by developmental biologist Kathy Niakan at the Francis Crick Institute in London, will inactivate genes involved in
very early embryo development, in hopes of understanding why some pregnancies terminate.
Not exact matches
During normal
embryo development, X inactivation in females takes place at a
very early stage.
The ability to keep human
embryos developing in the lab for almost 2 weeks — achieved for the first time this year — should provide new insights into
very early human
development, and generate debate on whether ethical limits on studying
embryos in culture should be extended.
Very soon after fertilization, the control of embryonic
development shifts from pre-existing maternal gene products to the products of genes encoded by the
early embryo (or zygote).
Hamburger grafted limb buds onto chick
embryos at
very early stages of
development and observed how the modified peripheral field was innervated by sensory and sympathetic fibers.
A second method involves introducing the transgenic DNA into embryonic stem cells (ES cells) derived from a mouse
embryo at the
very early stages of
development.
Kathy Niakan and colleagues are providing new understanding of the genes responsible for a crucial change when groups of cells in the
very early embryo first become organised and set on different paths of
development.
In answer to the question of whether hybrid
embryos created by CNR might be likely to develop if placed into a woman, the Royal Society notes that it is impossible to answer this question without carrying out an illegal experiment, but that experience to date with other inter-specific hybrid
embryos suggests that
development beyond the
very earliest stages of gestation would be unlikely.