One of the largest association studies of the recent past has come from analysis of the data by combining three
very large cohort studies — the Nurses Health Studies I and II as well as the Health Professional's Follow Up study.
Very recently, a rather limited number of retrospective
studies, utilizing whole genome sequencing (Talkowski et al., 2012) or whole exome sequencing (WES) in small
cohorts of neonates and aborted fetuses with various ultrasound and / or post-mortem structural abnormalities (Carss et al., 2014; Drury et al., 2015; Alamillo et al., 2015; Westerfield et al., 2015), provided initial proof - of - principle of
large - scale prenatal next generation sequencing (NGS).
I posit that a long - term
very low - carb
cohort study and associated fecal sampling would provide a
larger and more accurate data pool for conclusions of gut changes over time.