Inhibition of dynamin completely blocks compensatory synaptic
vesicle endocytosis.
Researchers at the Okinawa Institute of Science and Technology Graduate University (OIST) have found that the protein hinders a key step involved in the transmission of neuronal signals, which is essential for higher - brain functioning:
vesicle endocytosis at the nerve terminal.
Not exact matches
The retrieval of an emptied
vesicle membrane is called «
endocytosis,» and it is this process that an overabundance of alpha - synuclein disrupts.
«If you inhibit [
endocytosis in the nerve terminal], then the
vesicle recycling becomes slower and the supply of the
vesicles is inhibited,» OIST Professor Tomoyuki Takahashi from the Cellular and Molecular Synaptic Function Unit explains.
«Without this specialized neurotransmitter recycling and
endocytosis, synaptic
vesicles are not recycled fast enough to keep up with nerve and muscle cell activity,» she said.
Many cells ingest food and other materials through a process of
endocytosis, where the outer membrane invaginates and then pinches off to form a
vesicle.
Endocytosis has traditionally been viewed as a mechanism for achieving signal attenuation: activated cell surface receptors are internalised and trafficked through endocytic
vesicles to lysosomes, where they are degraded.