Overexpression of variant PNPLA3 gene at I148M position causes malignant transformation of hepatocytes
via IL -6-JAK2 / STAT3 pathway in low dose
free fatty acid exposure: a laboratory investigation in vitro and in vivo.
(a) The oxidative catabolism of
free fatty acids and amino
acids (
via the Respiratory Chain and Citric
Acid Cycle) might be inhibited in hypoxic cancer cells via the judicious use of agents which inhibit their availability, i.e., partially inhibit hepatic fatty acid synthesis and keep plasma amino acid levels within the normal range, thus decreasing ATP product
Acid Cycle) might be inhibited in hypoxic cancer cells
via the judicious use of agents which inhibit their availability, i.e., partially inhibit hepatic
fatty acid synthesis and keep plasma amino acid levels within the normal range, thus decreasing ATP product
acid synthesis and keep plasma amino
acid levels within the normal range, thus decreasing ATP product
acid levels within the normal range, thus decreasing ATP production;