Over-inhibition of 5AR results in increased availability of testosterone, which may be shunted,
via aromatase, to estradiol, causing «feminization,» e.g., gynecomastia, one of the side effects of 5AR inhibitor drugs; and decreased
production of not only 5α - DHT, but its metabolites, 5α - Androstane - 3α - 17β - diol (aka 3α - adiol, a storage form of 5α - DHT), and 5α - Androstane - 3β - 17β - diol (aka 3β - adiol), an estrogen receptor beta (ERβ) ligand that promotes
normal cellular differentiation, thus lessening risk of benign prostatic hypertrophy and prostate cancer.22, 23, 24
(a) The oxidative catabolism of free fatty acids and amino acids (
via the Respiratory Chain and Citric Acid Cycle) might be inhibited in hypoxic cancer cells
via the judicious use of agents which inhibit their availability, i.e., partially inhibit hepatic fatty acid synthesis and keep plasma amino acid levels within the
normal range, thus decreasing ATP
production;