When
testosterone is given, the need to compensate
via increased production of 5α - DHT is removed; the androgen receptors are now also being activated by
testosterone, resulting in signaling for reduced synthesis of 5α - reductase and / or reduced 5α - reductase activity.41 In sum, the research suggests that
testosterone replacement promotes normalization of 5α - reductase activity, 5α - DHT levels and its metabolism to 3β - adiol.