Sentences with phrase «viral infection models»

Not exact matches

These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.

Based primarily at Harvard with Maniatis, tenOever developed a knockout mouse model to study a particular protein, IKKε, that's involved in the immune response to viral infection.

The mouse model should also be useful for studying the immunological reactions and viral clearance in hepatitis B virus infection, they note in the Journal of Virology.

In mouse models of disease, Yale researchers looked at the effects of providing nutrients during infection and found opposing effects depending on whether the infections were bacterial or viral.

«The protein targets offer a faster, more cost - effective model for rapid screening and diagnoses of viral infections,» Woods said.

Together with her colleagues Margaret MacGibeny, an M.D. / Ph.D. student, then - postdoctoral researcher Ian Hogue, and Lynn Enquist, the lab's principal investigator and the Henry L. Hillman Professor in Molecular Biology, Koyuncu has used this unique latency model system to reveal specific cellular and viral components that can prevent the infection from going to sleep.

«The fruit fly is a well - known model organism used to understand human biology as it, like all other living organisms, has to fend off various viral infections.

Dr Chen said: «Our model and its results can be used to understand realistic systems like pneumonia, where bacterium like Streptococcus pneumoniae interacts with viral respiratory infections like flu, and one pathogen increases the susceptibility towards the other up to 100-fold.

Based on their expertise in immunology and pathology and the available infection models, vaccines against most relevant viral and bacterial animal infections can be tested.

She is broadly interested in using computational techniques to model the in - host population dynamics of viral infections, and is particularly interested in modeling the interactions between Human Immunodeficiency Virus and the immune system.

In this regard, animal model studies with FIPV in cats and RSV in mice have indicated that viral surface proteins may be the sensitizing protein of inactivated vaccines for immunopathology with infection [32], [45].

The system can be used by researchers as a model to elucidate how viral infections contribute to exacerbations, gain insight into mechanism of action of drugs, and could potentially help identify new therapeutic targets.

To understand gene regulation, Panne works on a cell - free model of the human interferon beta response to viral infection.

To conduct the study, Sanjabi and her team created a new model of viral infection through the rectum that uses lymphocytic choriomeningitis virus (LCMV), a rodent virus often used in research to model other pathogens.

Our group uses primary cell isolates and in vivo models to study viral and parasitic infections that pose a threat to the blood supply.

We also work closely with many of the investigators at BSRI using in vitro and in vivo models to study various viral and parasitic diseases with the goal of developing methods of preventing infection or new therapies

In addition, several reports suggest involvement in the activation of the immune response upon viral infection (Lupfer et al., 2013) and the requirement for the NOD2 / RIPK2 molecular pathway in several models on inflammatory diseases, including experimental colitis (Branquinho et al., 2016) and arthritis (Vieira et al., 2012).

Moreover, knock in animal models for syngeneic studies and allowing us to isolate transgenic armed effector cells are developed in order to show proof of concept for the diverse applicability of our modular targeting systems including for tumor diseases, autoimmune diseases, GvHD, transplantation / rejection as well as viral infections.

«Adventures in the Human Virosphere: The Use of Three - Dimensional Models to Understand Human Viral Infections.»