Sentences with phrase «viral vector systems»

The tables below list some components most commonly found in viral vector systems.

In the early 1990s, researchers developed viral vector systems based on retroviruses like Moloney murine leukemia virus (MMLV).

Read on for a brief description of the viruses used to make these vectors as well as a table defining the major elements found within the plasmids comprising the viral vector systems.

Therapeutic DNA is largely delivered using viral vector systems based on adenoviruses (Ad), adenoassociated viruses (AAV), and lentiviruses (LV).

Therapeutic DNA typically is delivered using a viral vector system, and adenoviruses have been used for this purpose for over 20 years (1 — 3).

To design a viral vector system that could do both, Addgene depositor

To design a viral vector system that could do both, Addgene depositor Didier Trono and collaborators turned to the lentivirus HIV - 1, well - known to infect non-dividing cells.

Not exact matches

In all three animal models, the researchers utilized a recombinant adeno - associated viral (rAAV) vector delivery system based on a subtype known as AAV - DJ / 8.

Since the discovery of the genetic basis for cystic fibrosis in 1989, scientists have developed a variety of viral and non-viral vector systems for delivering a corrected CFTR gene back into lung cells.

But when combined with adenovirus - vectored inteferon (a protein prepped with viral material that helps trigger the immune system), three out of four cynomolgus monkeys survived three days after infection.

Adeno - associated viral (AAV) vectors are the most frequently used gene - transfer tools in the study of the brain and spinal cord, which together are known as the central nervous system (CNS).

Viral vectors have the main adverse effect of inducing neutralizing antibodies, while several non-viral vectors present toxic effects (e.g. respiratory system).14, 15 In an effort to deliver efficiently the necessary drug concentration to the tumor site and prevent systemic adverse effects, the concept of administering local treatment for lung cancer has been explored.

A strong reaction by the patient's immune system to a specific type of viral vector delivering the gene led to the failure of multiple organs.

Viral Manufacturing To manufacture viral vectors, two approaches generally are adopted for culturing purposes: scale - out of adherent - cell systems based on 2D planar technologies and scale - up of 3D suspension cell cultures in stirred - tank bioreacViral Manufacturing To manufacture viral vectors, two approaches generally are adopted for culturing purposes: scale - out of adherent - cell systems based on 2D planar technologies and scale - up of 3D suspension cell cultures in stirred - tank bioreacviral vectors, two approaches generally are adopted for culturing purposes: scale - out of adherent - cell systems based on 2D planar technologies and scale - up of 3D suspension cell cultures in stirred - tank bioreactors.