Prior to joining IDRI, Neal worked as a research scientist for Immune Design Corporation (IDC), where he was a member of a team focused on design, generation, and testing of a novel
viral vector vaccine platform.
Kathy — Landscapes that look like another world (but they are from Spain) Rich — Brighton Collaboration;
Viral Vector Vaccines Safety Working Group (V3SWG)(Chen & DeStefano: Vaccine adverse events: causal or coincidental?)
Not exact matches
A new study led by scientists at Beth Israel Deaconess Medical Center (BIDMC) shows that an HIV - 1
vaccine regimen, involving a
viral vector boosted with a purified envelope protein, provided complete protection in half of the vaccinated non-human primates (NHPs) against a series of six repeated challenges with simian immunodeficiency virus (SIV), a virus similar to HIV that infects NHPs.
Identification of optimal
vaccine formulations and administration routes for the induction of CD8 + T - cell responses (SSI): The induction of suitable CD8 + T - cell responses following vaccination usually requires the use of live
viral vectors.
The
Viral Vector Core Facility produces recombinant virus -
vectored vaccines for pre-clinical validation experiments and GMP starting material.
Firstly, it will develop optimised
viral vectors suitable for expressing antigens from a range of different diseases, to create novel
vaccines.
Assessment of chimpanzee adenovirus serotype 63 neutralizing antibodies prior to evaluation of a candidate malaria
vaccine regimen based on
viral vectors.
Combining
Viral Vectored and Protein - in - adjuvant
Vaccines Against the Blood - stage Malaria Antigen AMA1: Report on a Phase 1a Clinical Trial.
Dr Ho works in NIBSC since 1998 and leads R&D and standardisation projects collaborating with
vaccine manufacturers in laboratory evaluation of product characterisation and quality control assays for novel bacterial
vaccines, including protein subunit, polysaccharide - protein conjugates,
viral vector and live bacterial
vaccines.
The program will be packed with papers on biochromatography, downstream processing, QbD, monoclonal antibodies, plasmids, enzymes,
vaccines,
viral vectors for gene delivery, VLPs, and other biopharmaceuticals, chiral molecules, SFC, fine chemicals, peptides, proteins, oligonucleotides, APIs, natural products, batch, multi-column and continuous SMB processes, column technology and equipment, monoliths, new and improved stationary phases, membrane chromatography, regulatory aspects, and more!
Platform - this is the mechanism (e.g.
viral vector) by which the
vaccine is introduced and (if applicable) is replicated within the host
MHRP scientists, working with NIAID, have developed an attenuated
viral vector — modified vaccinia Ankara —
vaccine candidate, MVA - CMDR (HIV - 1 CM235 env / CM240 gag - pol).
This proof - of - concept study, which tested MVA, Ad26, and Ad35
vector - based
vaccines, is the first to show partial
vaccine protection in the stringent animal model involving heterologous, neutralization - resistant SIVmac251
viral challenges in rhesus monkeys.
p. 3» When compared with infectious (attenuated, avirulent, modified live, recombinant
viral vectored)
vaccines, noninfectious
vaccines are more likely to produce local and systemic adverse reactions in some dogs.»
p. 34» The vaccination protocol that includes the minimum number of
vaccines yet still provides a reasonable opportunity to immunize the dog would be: a single dose of combined infectious (attenuated, avirulent, modified live, recombinant
viral vectored) CDV, MLV CPV - 2, with MLV CAV - 2, administered at 16 wk of age or older, plus a rabies shot at the same time (but inoculated at a separate site on the body).
Recombinant:
Vaccine manufactured through gene cloning (plasmid expressed) or by recombining selected DNA from a pathogenic organism with DNA from another virus (
viral vectored), leading to the expression, following inoculation, of only essential antigens required to immunize.
Strong background in molecular biology / cell biology with emphasis on virology, cell cultures,
viral vectors, protein design and
vaccine.