Of note, AG490 did not affect pSTAT1, pSTAT3 or pSTAT6 positivity in either parous or
virgin early lesions (Figure 6 — figure supplement 1B).
Not exact matches
It was even lower in the
early lesions of I10 mice than in those of age - matched
virgin mice, suggesting that the molecular network activated in normal epithelia at involution to arrest the cell cycle (Figure 1 — figure supplement 3B) also operates in these premalignant cells.
In addition, in any
virgin mouse, some of the
early lesions had relatively high percentage of pSTAT5 cells, and they correspondingly showed reduced levels of apoptosis (Figure 4 — figure supplement 2).