«While we observed
virulence differences, we speculate that it is completely within the variation that one would observe with terrestrial isolates,» said Mr. Knox.
(LA JOLLA, CA)-- February 11, 2016 — The J. Craig Venter Institute (JCVI) researcher Hernan Lorenzi, Ph.D., in collaboration with L. David Sibley, Ph.D., Washington University School of Medicine, and a team of international researchers have published a paper outlining key genetic differences in strains of Toxoplasma gondii which shed light into the biological and
virulence differences between T. gondii strains and between other closely related parasites.
Not exact matches
Prior to mosquito transmission (A),
differences between the I - lines and N - lines were significant in three out of the four cases (p < 0.05 for lines from the unadapted line infecting naïve mice, p < 0.01 for unadapted infecting immunized, and p < 0.001 for preadapted infecting immunized): in the fourth case (p > 0.1 for preadapted infecting naïve),
virulence of the ancestral line was already apparently near - maximal.
Our data are consistent with this idea, since mosquito transmission eliminated the
difference between the I - lines and N - lines in immunized mice but not in naïve mice, suggesting that part of the
virulence advantage in immunized hosts was due to novelty in the clonally variant surface antigens.