Sentences with phrase «virulence factors»

Excess labile carbon promotes the expression of virulence factors in coral reef bacterioplankton — Anny Cárdenas, ISME

«Systems analysis of multiple regulator perturbations allows discovery of virulence factors in Salmonella.»

For example, by performing a Description Logic (DL) query in the OWL editor Protégé 4 or a SPARQL query in an IDOBRU SPARQL server, a check of Brucella virulence factors showed that eight of them are known protective antigens based on the biological knowledge captured within the ontology.

Kim Orth of the University of Texas Southwestern Medical Center and the Howard Hughes Medical Institute has worked to elucidate the activity of bacterial virulence factors on the molecular level, providing insights into how bacteria cause disease and how eukaryotic host cells signalin response to infection.

One central theme in PHI research is the identification and understanding of virulence factors from various pathogens.

Until now, research has mainly focused on FIC proteins which are injected as virulence factors by pathogenic bacteria into host cells.

«Our results are very exciting ─ we are not just talking about one molecule in one particular pathogen but rather a building block which is shared by thousands of common virulence factors produced by many major pathogenic bacteria.

Venkateswaran agrees that they need to do more work to assess whether any dangerous pathogens are lingering in the ISS, which they hope to do by isolating intact bacteria and looking for virulence factors, increasing the length of the DNA chains they can sequence, and expanding their analyses to include viruses.

I became fascinated by the huge arsenal of virulence factors required by enteric pathogens in order to survive and proliferate in the gut environment.

The unit identified virulence factors promoting the successful establishment of selected methicillin resistant S.aureus and KPC producing K.pneumoniae clones in hospitals.

Bacterial toxins are a key virulence factors in that modulate host signaling pathways [41].

Analysis of such interactions provided both verification of known virulence factors and identification of three new putative virulence proteins.

H. pylori has several virulence factors that interact with specific targets in the cell and directly affect the severity of gastric disease.

«We conducted standard single and multi-gene comparisons with whole - genome approaches and identified potential virulence factors to discriminate new species from among the more traditional set.

Chemotactic machinery guides H. pylori into the damage site to colonize, and then other virulence factors take over to make sure the site stays just as tasty in the long term by slowing repair of any damage.»

Their findings — that nanotubes and vesicles are an important part of the communications process — show that the extracellular vesicles contribute to the complexity of African trypanosomiasis through the transfer of virulence factors between parasites and inadvertent interaction with host cells, which has a profound effect on disease, the study notes.

A common pathogen producing this nlp20 - containing virulence factor is Phytophthora infestans, which causes potato blight.

In addition, the group focus on virulence factors responsible for antimicrobial drug resistance in nosocomial pathogens.

Notably, some of these enzymes present in Pds (urease, proteinase (aspartyl), and superoxide dismutase) are found in other pathogenic fungi [12], [13] and are considered dual virulence factors [14].

Though the results of the experiment allowed Abate's lab to distinguish individual microbial species, identify antibiotic resistance genes, and find virulence factors, he sees substantial room for improvement.

During this infection process, the bacterium produces many virulence factors, including a lethal toxin, that allow it to subvert the host immune response.

The study, «Extracellular vesicles from Trypanosoma brucei mediate virulence factor transfer and cause host anemia,» was supported by the National Institutes of Health under grant numbers AI039033, AI060546 and 2G12MD007592.

Dr. Sibley added, «Identification of important pathogenesis determinants on a genome - wide level will foster mechanistic studies on the function of key parasite virulence factors and help to improve diagnosis and treatment of toxoplasmosis.»

The ability to image these first early stages of infection therefore facilitates a direct examination of the Mcf1 virulence factor neutralizing the phagocytic role of the embryonic hemocytes.

It is possible, for example, to examine the effects of a recombinant bacterial toxin on infection, but it is more difficult to examine the role of specific virulence factors in neutralizing specific elements of the immune system, such as phagocytes.

We have generated a manually curated database, which is called Victors, to store and analyze various virulence factors from different pathogens that infect humans and animals.

These include known and novel virulence factors.

The ability of staphylococcal and streptococcal bacteria to cause disease is due to numerous virulence factors, among which a group called Superantigens play a prominent role.

Scientists exposed animals to M1 protein, which is a potent virulence factor derived from a subgroup of Streptococcus pyogenes that are associated with a high mortality upon infection.

Once bound to CEACAM, Helicobacter pylori can transfer additional proteins, so - called virulence factors, to the stomach cells.

Next, Dehio's team aims to elucidate the evolutionary link between these original FIC toxins and the FIC proteins, which are injected as virulence factors into host cells by diverse pathogens.

«Our studies showed that the GlcNAc sugar of GAC is a critical virulence factor allowing strep to spread in the blood and tissues,» van Sorge said.

These products, including the major malarial by - product hemozoin, malarial proteins and as yet undefined virulence factors, induce MyD88 - dependent inflammatory responses in osteoclast and osteoblast precursors, leading to increased RANKL expression (a key molecule inducing osteoclast differentiation), and over-stimulation of osteoclastogenesis favoring bone resorption.»

We assessed major virulence factors of C. neoformans (growth at 37 °C and melanin production on niger seed (NS) or L - DOPA media), sensitivity to the antifungal drugs fluconazole (FLC) or FK506, and unisexual reproduction (self - filamentous growth)(Figure S3).

Access to both purified Mcf1 toxin and recombinant E. coli expressing the mcf1 gene makes this an ideal virulence factor in which to study early interactions between an insect pathogen and insect phagocytes.

We have been developing the Gram - negative bacterium Photorhabdus asymbiotica as a model system in which to study cross-talk between virulence factors developed against insects that can also be deployed against mammalian immune responses.

Novel Burkholderia mallei virulence factors linked to specific host - pathogen protein interactions.

We used bioinformatics tools, including orthology detection and ab initio predictions of secretion system proteins, as well as published experimental Burkholderia data to initially select a small number of proteins as putative virulence factors.

Using host - pathogen protein interactions to identify and characterize Francisella tularensis virulence factors.

tabaci regulates virulence factors via N - acyl homoserine lactone and fatty acid synthesis.

Some candidate virulence factors present in UM270 genome were detected and found to perform the following putative functions: a 3 - oxoacyl -[acyl - carrier - protein], catalase, capsule polysaccharide export, endoglucanase, cyclolysin secretion ATP - binding protein and diguanylate cyclase.

Rather than the expected virulence factor, the newly discovered E. coli - specific genes helped protect the bacteria from the toxic effect of metal ions the body uses to fight infection.

The analysis also revealed that Salmonella infection increases mitochondrial abundance of the enzyme superoxide dismutase and decreases the abundance of the sorting nexin protein SNX6, most likely through the bacterial virulence factor SopB.

In addition, the department is focusing on the study of the mechanisms for the differentiation of immune cells by mycobacterial virulence factors to develop the effective control tools of M. tuberculosis infection.

Crystal structure of virulence factor CJ0248 from Campylobacter jejuni at 2.25 A resolution reveals a new fold.