Sentences with phrase «virus cell entry»

Not exact matches

All animal viruses have to cross membranes for cell entry and exit.

This protruding part of the antibody binds to a viral site that remains the same between strains, because the virus needs it to gain entry to a cell.

Dr Daniel Watterson, joint first author of the paper with Dr Jie Li, said that the antibody can block entry to the host cell, an essential step in the virus lifecycle.

Only viruses that have mutated escape mechanisms from immune pressures are able to survive, but the mutations come at the cost of other aspects of viral fitness, perhaps inhibiting entry into cells or integration into cell DNA.

A panel of small molecules that inhibit Zika virus infection, including one that stands out as a potent inhibitor of Zika viral entry into relevant human cell types, was discovered by researchers from the Perelman School of Medicine at the University of Pennsylvania.

Robyn Biti, Graeme Stewart of Westmead Hospital in Sydney, Australia, and colleagues report that they have found an HIV - infected homosexual man whose white blood cells contain a defective copy of a critical surface protein, called CCR5, that the virus uses to gain entry into the cells.

«Overall, the most important finding is that we identified nanchangmycin as a potent inhibitor of Zika virus entry across all cell types tested, including endothelial and placental cells, which are relevant to how Zika may enter the fetus,» Cherry said.

Greber and his team infected human cells in culture with the chemically labeled viruses, and observed the behavior of the viral DNA during entry into cells.

Novitch's UCLA lab group has likewise used its brain organoids to pinpoint additional receptors by which the virus may gain entry into neural stem cells, and identified a few other drug leads for blocking infection.

The vaccine contains DNA much like the virus uses to encode a protein for cell entry.

When they inserted a fluorescent reporter protein in this virus - like shell, their test became capable of high - speed screening to see which drugs blocked the entry of Ebola - like viral particles into cells as measured by fluorescence.

Scientists pre-treated human liver cells in vitro with SBEL1 prior to HCV infection and found that SBEL1 pre-treated cells contained 23 percent less HCV protein than the control, suggesting that SBEL1 blocks virus entry.

Drugs known as entry inhibitors (Pfizer's maraviroc and Schering - Plough's vicriviroc) stop the virus from entering healthy cells by binding to receptors on the cells» surfaces.

«Making the movements of HIV visible so that we can follow, in real time, how surface proteins on the virus behave will hopefully tell us what we need to know to prevent fusion with human cells — if you can prevent viral entry of HIV into immune cells, you have won,» says Dr. Blanchard, who is also associate director of Weill Cornell's chemical biology program.

«Sumudu has shown that liver cells that express high levels of the IFITM proteins are resistant to infection with the hepatitis C virus by blocking entry of the virus into the cells,» Associate Professor Beard says.

The researchers have shown for the first time that antiviral proteins (the IFITM proteins) produced through the natural immune response block the entry of the hepatitis C virus into the cell.

Two - pore channels control Ebola virus host cell entry and are drug targets for disease treatment

In addition, the strain isolated from lions and hyenas during the 1993/1994 epidemic had rare mutations in two viral proteins: the CDV - H protein, which binds to the host cell receptor (called SLAM CD 150) and therefore plays an important role to facilitate viral entry into host cells, and the CDV - V protein, which enables the virus to manipulate the innate immune response of the host.

If approaches could be developed that specifically target expression of both CCR5 and CXCR4 on CD4 + T cells, virus entry should be inhibited more effectively.

They inhibit viral infection by preventing viral entry into target cells and by blocking different stages of the viral replicative cycle for different viruses.

FRIEND OR FOE A dengue antibody (blue, shown bound to a dengue virus protein, red, in this molecular model) can ease Zika's entry into cells, a new study finds.

Molecular virology, cell biology of virus infection, HIV assembly and structure, virus entry and uncoating, viral proteases, antiviral drugs, resistance development, prevention of viral diseases

Additional experiments showed the feasibility of creating a two - layer security system for T cells by simultaneously blocking a gene the HIV virus needs to gain entry into cells and a gene the virus needs to survive and reproduce within the cell, resulting in doubly secure resistance.

Prototype foamy virus protease activity is essential for intraparticle reverse transcription initiation but not absolutely required for uncoating upon host cell entry.

Vaxwave ® is based on lymphocytic choriomeningitis virus (LCMV) and in this vector the gene encoding the LCMV envelope protein, normally responsible for virus entry into target cells, has been deleted and replaced with a target gene of interest.

Siliciano's talk was followed by another keynote address by Stephen Harrison from Harvard Medical School, which introduced the Cell Biology of Virus Entry, Replication and Pathogenesis track of the meeting.

«The plasma membrane also dynamically changes shape during cell migration, cancer cell invasion, cell division, nutrient uptake, and entry of pathogens and viruses into cells,» Shin explains.

It was created by «wiring together» two natural proteins - one that detected virus entry, and another that acted as a suicide switch that kills the infected cell.

The antiviral restriction factor IFN - induced transmembrane protein 3 (IFITM3) inhibits cell entry of a number of viruses, and genetic diversity within IFITM3 determines susceptibility to viral disease in humans.

Unlike its derivatives, the study results demonstrated that EGCG inhibits entry of hepatitis C virus into liver cells.

Flublok's novel manufacturing technology allows for production of large quantities of the influenza virus protein, hemagglutinin (HA)-- the active ingredient in all inactivated influenza vaccines that is essential for entry of the virus into cells in the body.