Sentences with phrase «virus genomes»

Finding a treasure trove of new virus genome sequences has opened the door to using those data to identify previously unknown microbial hosts, as well.

What processes or pathways enable virus genomes to remain in a productive infection mode where genomes are expressed, and viral proteins and new virus particles are produced?

They are also further investigating the rate of viral evolution during persistent infections by sequencing Ebola virus genomes from the semen of disease survivors.

Despite the precedent set by the response to the Ebola epidemic, Bedford and Dudas point out that fewer researchers have shared Zika virus genomes from the more recent crisis in Brazil, Central America and the Caribbean.

In November, Brazilian researchers detected the Zika virus genome in amniotic fluid samples from two women whose fetuses were been diagnosed with microcephaly by ultrasound exams, the Pan American Health Organization reported.

The finding doubles the number of recognized virus genera — a biological classification one step up from species — and increases the number of sequenced virus genomes available for study almost tenfold.

Professor Paul Kellam, Group Leader of Virus Genomics at the Wellcome Trust Sanger Institute, said: «Real - time analysis of virus genomes such as Ebola is an important addition to our toolkit for investigating disease outbreaks.

More recently, sequences of 99 Ebola virus genomes taken from 78 confirmed patients at different points in their infections helped to map the origin and spread of the virus during the 2014 outbreak in Sierra Leone.

«The high pressure caused by the densely packed herpes virus genome also means that if one unit is weakened, the whole structure will fall apart,» said Ren Sun, a professor of molecular and medical pharmacology, and bioengineering, a member of the California NanoSystems Institute and the study's co-senior author.

Ultracentrifuge - purified BYDV - byd1 virus (fifth passage on DEF monolayer) was used for virus genome amplification.

«Finding a giant virus genome took the project into a completely new and unexpected, yet very exciting direction.»

Many older genomes are not listed here, including dozens of bacterial genomes sequenced when the lab was at TIGR (1997 - 2005) and the University of Maryland (2005 - 11), and hundreds of influenza virus genomes sequenced at TIGR for the Influenza Genome Sequencing Project, which our lab co-founded and which is still ongoing at NIAID.

Virus genome analysis has played a bigger role in understanding the West African Ebola epidemic than for any other infectious disease outbreak for two reasons: modern advances in sequencing technologies and scientists who were unusually willing to share data.

This mumps sequencing effort builds on our group's past experiences working together with long - term collaborators and forming partnerships with new ones to quickly generate and share virus genome data during major outbreaks, especially the 2014 - 15 Ebola outbreak in West Africa and the 2015 - 16 Zika outbreak in the Americas.

Multiplex PCR method for MinION and Illumina sequencing of Zika and other virus genomes directly from clinical samples.

Ebola virus genome plasticity as a marker of its passaging history: A comparison of in vitro passaging to non-human primate infection

Normally, the Ebola virus genome only mutates at just under half that speed.

«This is the first Zika virus genome isolated from semen, but we need many more,» said Atkinson.

The sorter scoured public databases of sequenced microbial genomes, looking for fragments of genomes that resembled virus genomes that had already been sequenced — for starters.

«ID «ing features of flu virus genome may help target surveillance for pandemic flu: Findings may help health experts know which strains to watch.»

Because Ebola diagnostics and some therapeutics like vaccines are based on the specific viral sequence, it is important for researchers to have the most up - to - date virus genome sequence possible.

Nandan S. Gokhale, a graduate student in Horner's lab, in collaboration with the lab of Christopher E. Mason at Weill Cornell Medicine, employed the latest sequencing techniques to map the locations of the N6 - methyladenosine modifications on the hepatitis C virus genome.

Together the pieces represented about 15 % of the camel virus genome and these parts were almost identical to the genome sequenced from the patient.

Firstly, MSI1 binds to the Zika virus genome allowing it to replicate and making the cells more vulnerable to virus - induced cell death.

«Ebola virus genome provides clues to repeated disease «flare - ups» in Western Africa.»

«The tests that are used to detect virus detect the virus genetic material — its so - called genome — and detecting virus genome doesn't mean that infectious virus is present.»

The 1,610 Ebola virus genomes analyzed by the researchers represented more than 5 percent of the known cases, the largest sample analyzed for a single human epidemic.

To assess transmission potential, a key component of viral fitness, we calculated the cumulative virus genome copy number (VCN) shed rate over the lifetime of an infection.

Enquist agreed and gave the bottom line: «We identified the class of viral proteins that supercharge the neuronal stress response to wake up sleeping herpes virus genomes.»

Further searching through the metagenomic datasets uncovered three more related giant virus genomes.

Reporting Jan. 31 in Nature Communications, the researchers identified features of the influenza virus genome that affect how well the virus multiplies.

During the Ebola outbreak in Africa in 2014, patients tested for the disease had to provide a blood sample fortesting in a specialist lab by highly trained staff., There are only a few of these facilities in the world, including Public Health England's Lab in Porton Down in the UK, with each diagnosis of the Ebola virus genome taking between5 - 8 hours to confirm.

Sequencing virus genomes from even a fraction of people infected in an epidemic and comparing mutation patterns can give researchers valuable information about how big the epidemic is, how long it has been spreading and where transmissions chains start and end, said Dr. Trevor Bedford, a Fred Hutch evolutionary biologist and one of the paper's authors.

An international effort to analyze the entire database of Ebola virus genomes from the 2013 — 2016 West African epidemic reveals insights into factors that sped or slowed the rampage and calls for using real - time sequencing and data - sharing to contain future viral disease outbreaks.

Palacios and first author Jason Ladner of USAMRIID sequenced Ebola virus genomes from 139 EVD patients affected in the second, largest wave of the Liberian outbreak.

Furthermore, a virus genome (the entire complement of DNA or RNA) can permanently colonize its host, adding viral genes to host lineages and ultimately becoming a critical part of the host species» genome.

The color orange is used to indicate parts of the particle encoded by the virus genome, whereas gray represents parts captured from the host cells.

In earlier work published in Proceedings of the National Academy of Sciences, Peersen and co-authors had discovered the exact chemical steps by which the RNA - dependent RNA polymerase copies the virus genome.

This drawing shows part of the atomic - level structure of coxsackievirus B3 polymerase, which is responsible for making copies of the virus genome.

We sequenced 99 Ebola virus genomes from 78 patients in Sierra Leone to ~ 2000 × coverage.

Accumulated mutations in the virus genomes reveal that the outbreak began well before the medics arrived in the country.

«Fishing expedition» nets nearly tenfold increase in number of sequenced virus genomes.»

These findings, revealed today in Nature in a paper led by Pardis Sabeti of the Broad Institute and Harvard University, arise from an analysis of 174 Zika virus genomes — including the largest collection of new Zika virus genomes to date — sequenced from patient and mosquito samples collected in 11 affected countries and territories.

If this surface is mutated on the replicase, it loses its ability to accurately recognise the virus genome, which has fatal consequences for the virus, which can no longer replicate.

Their search turned up a suspect: a piece of a receptor for hypocretin resembles part of the H1N1 influenza nucleoprotein — which binds to the virus genome and plays a key role in its replication.

In cells infected with Zika virus MSI1 binds to the virus genome in favour of its normal targets in the cell.

We will use these data to determine whether any mutation (s) in the virus genome affect disease severity.

This defense system works for Streptococcus pyogenes, using a duplex of two small RNA molecules that contain sections of the virus genome called «clustered regularly interspaced short palindromic repeats» (CRISPR), which carry the memory of a previous attack.